Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Joao Arezes"'
Autor:
Sarah Gooding, Sam W. Z. Olechnowicz, Emma V. Morris, Andrew E. Armitage, Joao Arezes, Joe Frost, Emmanouela Repapi, James R. Edwards, Neil Ashley, Craig Waugh, Nicola Gray, Erik Martinez-Hackert, Pei Jin Lim, Sant-Rayn Pasricha, Helen Knowles, Adam J. Mead, Karthik Ramasamy, Hal Drakesmith, Claire M. Edwards
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Multiple myeloma is a cancer of the bone marrow that can induce bone disease. Here, the authors profile the transcriptome of bone-lining cells and find a targetable role of bone morphogenetic protein (BMP) signalling in myeloma-induced bone-disease
Externí odkaz:
https://doaj.org/article/afce39d2e8774212826676e3142ffc40
Autor:
Joao Arezes, Monica Costa, Ines Vieira, Vera Dias, Xiao L Kong, Rui Fernandes, Matthijn Vos, Anna Carlsson, Yuri Rikers, Graça Porto, Maria Rangel, Robert C Hider, Jorge P Pinto
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79870 (2013)
Iron is an essential nutrient in several biological processes such as oxygen transport, DNA replication and erythropoiesis. Plasma iron normally circulates bound to transferrin. In iron overload disorders, however, iron concentrations exceed transfer
Externí odkaz:
https://doaj.org/article/03cb88044525494cafe3ffbb64347377
Autor:
Alexander Drakesmith, Reema Jasuja, Simon J Draper, John E. Murphy, Debra D Pittman, Matthew Lambert, Orla Cunningham, Edward LaVallie, Joe Frost, Pei-Jin Lim, Sant-Rayn Pasricha, Andrew E Armitage, Doris Quinkert, Kirsty McHugh, Zachary Maben, May S Tam, Anagha Sawant, Susan Benard, Niall Foy, Joao Arezes
Publikováno v:
Blood. 134:964-964
Erythroferrone (Erfe) is produced by erythroblasts in response to erythropoietin (EPO) and acts in the liver to prevent hepcidin stimulation by BMP6. Hepcidin suppression allows for the mobilization of iron to the bone marrow for the production of re
Autor:
Sant-Rayn Pasricha, Pei Jin Lim, Tiago L. Duarte, Carla Casu, Dorenda Oosterhuis, Katarzyna Mleczko-Sanecka, Maria Suciu, Ana Rita Da Silva, Kinda Al-Hourani, João Arezes, Kirsty McHugh, Sarah Gooding, Joe N. Frost, Katherine Wray, Ana Santos, Graça Porto, Emmanouela Repapi, Nicki Gray, Simon J. Draper, Neil Ashley, Elizabeth Soilleux, Peter Olinga, Martina U. Muckenthaler, Jim R. Hughes, Stefano Rivella, Thomas A. Milne, Andrew E. Armitage, Hal Drakesmith
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling. Here, Pasricha et al. demonstrate that the hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoi
Externí odkaz:
https://doaj.org/article/15032712babd4934b8cf9987f86cc0ba