Výsledky vyhledávání - "Joao A. Pedras-Vasconcelos"

Akademický článek

Proceedings of the 14th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals

Autor: Sophie Tourdot, Daniel Baltrunkonis, Sofie Denies, Viswanath Devanarayan, Joanna Grudzinska-Goebel, Arno Kromminga, Gregor P. Lotz, Laurent Malherbe, Lydia Michaut, Karin N. Weldingh, Joao A. Pedras-Vasconcelos, Laura. I. Salazar-Fontana, Sebastian Spindeldreher, Zuben Sauna, Veerle Snoeck, Daniela Verthelyi, Daniel Kramer

Publikováno v: mAbs, Vol 16, Iss 1 (2024)

Biologics have revolutionized disease management in many therapeutic areas by addressing unmet medical needs and overcoming resistance to standard-of-care treatment in numerous patients. However, the development of unwanted immune responses directed

Externí odkaz: https://doaj.org/article/3bd88e5978b34872b17ec5165f9aa0d5

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Increased CD8+ T Cell Memory to Concurrent Infection at the Expense of Increased Erosion of Pre-existing Memory: The Paradoxical Role of IL-15

Autor: Dean K. Smith, Yvan Chapdelaine, Lakshmi Krishnan, Joao A. Pedras-Vasconcelos, Subash Sad

Publikováno v: The Journal of Immunology. 171:5454-5460

The use of cytokines during vaccination, particularly IL-15, is being considered due to the unique ability of IL-15 to enhance the proliferation of memory CD8+ T cells. However, as homeostatic mechanisms limit excessive lymphocyte expansion, we addre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237696c94ad387a400038d2f711ba130
https://doi.org/10.4049/jimmunol.171.10.5454

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Expression of superoxide dismutase in Listeria monocytogenes

Autor: Harry Deneer, Joao A. Pedras Vasconcelos

Publikováno v: Applied and Environmental Microbiology. 60:2360-2366

The nature and expression of superoxide dismutase (SOD; EC 1.15.1.1) in the gram-positive food-borne pathogen Listeria monocytogenes were examined. Metal depletion and reconstitution studies and resistance to H2O2 and potassium cyanide inactivation i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6324f6d6fc5e95a9256639509360c5
https://doi.org/10.1128/aem.60.7.2360-2366.1994

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Cross-reactive antigen is required to prevent erosion of established T cell memory and tumor immunity: a heterologous bacterial model of attrition

Autor: Subash Sad, Yvan Chapdelaine, Henk van Faassen, Renu Dudani, Joao A. Pedras-Vasconcelos, Dean K. Smith

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 169(3)

Induction and maintenance of T cell memory is critical for the control of intracellular pathogens and tumors. Memory T cells seem to require few “maintenance signals,” though often such studies are done in the absence of competing immune challeng

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc8b036ba833903b1fdbe10e1714196
https://pubmed.ncbi.nlm.nih.gov/12133940

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Mycobacterium bovis BCG-infected mice are more susceptible to staphylococcal enterotoxin B-mediated toxic shock than uninfected mice despite reduced in vitro splenocyte responses to superantigens

Autor: Henk van Faassen, Yvan Chapdelaine, Subash Sad, Renu Dudani, Dean K. Smith, Joao A. Pedras-Vasconcelos

Publikováno v: Infection and immunity. 70(8)

Type 1 T-cell responses against intracellular pathogens play a crucial role in mediating protection. We examined whether the induction of a strong type 1 T-cell response during a chronic bacterial infection influences responses to superantigens capab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d202a25f656152b66c9296bc40277cb
https://pubmed.ncbi.nlm.nih.gov/12117923

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