Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Joao A. C. Lima"'
Autor:
Kathleen Connolly, Richard George, Sami Omar, Elin Matsson, Magnus Åstrand, Magnus Althage, Daniel Pettersen, Esha Mohamed, Kelly Fang, Joao A. C. Lima, Mirjana Kujacic, Helena Ödesjö, Michelle Turton, Petra Johannesson, Anders Gabrielsen, Marcin Ufnal
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 15 (2024)
Background Heart failure mortality remains high despite recent progress in pharmacological treatment. AZD3427 is a selective long‐acting analog of relaxin, a vasodilatory hormone with antifibrotic effects. We assessed the safety, pharmacokinetics,
Externí odkaz:
https://doaj.org/article/c0e3f5861c8c440da59d8312baa97e0d
Autor:
Emily S. Lau, Athar Roshandelpoor, Shahrooz Zarbafian, Dongyu Wang, James S. Guseh, Norrina Allen, Vinithra Varadarajan, Matthew Nayor, Ravi V. Shah, Joao A. C. Lima, Sanjiv J. Shah, Bing Yu, Mona Alotaibi, Susan Cheng, Mohit Jain, Gregory D. Lewis, Jennifer E. Ho
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Systemic inflammation has been implicated in the pathobiology of heart failure with preserved ejection fraction (HFpEF). Here, we examine the association of upstream mediators of inflammation as ascertained by fatty-acid derived eicosanoid a
Externí odkaz:
https://doaj.org/article/07f73b5e0093461e99f48c002b887e3d
Autor:
Omar Chehab, Elie Akl, Ashkan Abdollahi, Ralph Zeitoun, Bharath Ambale-Venkatesh, Colin Wu, Russell Tracy, Roger S. Blumenthal, Wendy S. Post, Joao A. C. Lima, Annabelle Rodriguez
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Emerging research indicates that high HDL-C levels might not be cardioprotective, potentially worsening cardiovascular disease (CVD) outcomes. Yet, there is no data on HDL-C's association with other CVD risk factors like myocardial fibrosis,
Externí odkaz:
https://doaj.org/article/82f0c66298e64295964f0933ffdf170d
Autor:
Xiaowei Hu, Jeongok G. Logan, Younghoon Kwon, Joao A. C. Lima, David R. Jacobs, Daniel Duprez, Lyndia Brumback, Kent D. Taylor, Peter Durda, W. Craig Johnson, Elaine Cornell, Xiuqing Guo, Yongmei Liu, Russell P. Tracy, Thomas W. Blackwell, George Papanicolaou, Gary F. Mitchell, Stephen S. Rich, Jerome I. Rotter, David J. Van Den Berg, Julio A. Chirinos, Timothy M. Hughes, Francine E. Garrett-Bakelman, Ani Manichaikul
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Despite the prognostic value of arterial stiffness (AS) and pulsatile hemodynamics (PH) for cardiovascular morbidity and mortality, epigenetic modifications that contribute to AS/PH remain unknown. To gain a better understanding of the link
Externí odkaz:
https://doaj.org/article/2566eec7931e4736bf4aa961b170b4a1
Autor:
Giancarlo Suffredini, Lan Le, Seoho Lee, Wei Dong Gao, Michael P. Robich, Hamza Aziz, Ahmet Kilic, Jennifer S. Lawton, Kristin Voegtline, Sarah Olson, Charles Hugh Brown, Joao A. C. Lima, Samarjit Das, Jeffrey M. Dodd-o
Publikováno v:
Journal of Clinical Medicine, Vol 13, Iss 12, p 3397 (2024)
Objectives: Risk assessment models for cardiac surgery do not distinguish between degrees of liver dysfunction. We have previously shown that preoperative liver stiffness is associated with hospital length of stay following cardiac surgery. The autho
Externí odkaz:
https://doaj.org/article/e1048a340b4346c68e9b454a6ad3bd6e
Autor:
Yoko Kato, Wei Hao Lee, Makoto Natsumeda, Bharath Ambale-Venkatesh, Kensuke Takagi, Yuji Ikari, Joao A. C. Lima
Publikováno v:
Frontiers in Radiology, Vol 4 (2024)
BackgroundLeft atrial (LA) mechanics are strongly linked with left ventricular (LV) filling. The LA diastasis strain slope (LADSS), which spans between the passive and active LA emptying phases, may be a key indicator of the LA–LV interplay during
Externí odkaz:
https://doaj.org/article/81dae7a83c3841b88b184cba61550fdd
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)
Abstract Greater physical fitness may lead to greater left ventricular mass (LVM) and reduce the effect of cardiometabolic risk factors on LVM. However, the cardiometabolic biomarkers associations for LVM have not been clarified in physically active
Externí odkaz:
https://doaj.org/article/f4d07b90184c420eb007f8ffb07fadc7
Autor:
Maria Doughan, Omar Chehab, Henrique Doria de Vasconcellos, Ralph Zeitoun, Vinithra Varadarajan, Bassel Doughan, Colin O. Wu, Michael J Blaha, David A. Bluemke, Joao A. C. Lima
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 3 (2023)
Background Periodontitis is a chronic inflammatory disease common among adults. It has been suggested that periodontal disease (PD) may be a contributing risk factor for cardiovascular disease; however, pathways underlying such a relationship require
Externí odkaz:
https://doaj.org/article/28d4012956af4703aec8fd1d7a6f9d64
Autor:
Chao Cong, Yoko Kato, Henrique Doria De Vasconcellos, Mohammad R. Ostovaneh, Joao A. C. Lima, Bharath Ambale-Venkatesh
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundAutomatic coronary angiography (CAG) assessment may help in faster screening and diagnosis of stenosis in patients with atherosclerotic disease. We aimed to provide an end-to-end workflow that separates cases with normal or mild stenoses fr
Externí odkaz:
https://doaj.org/article/47259e63bda24c18a52823aeda39beda
Autor:
Julian Krebs, Tommaso Mansi, Hervé Delingette, Bin Lou, Joao A. C. Lima, Susumu Tao, Luisa A. Ciuffo, Sanaz Norgard, Barbara Butcher, Wei H. Lee, Ela Chamera, Timm-Michael Dickfeld, Michael Stillabower, Joseph E. Marine, Robert G. Weiss, Gordon F. Tomaselli, Henry Halperin, Katherine C. Wu, Hiroshi Ashikaga
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Better models to identify individuals at low risk of ventricular arrhythmia (VA) are needed for implantable cardioverter-defibrillator (ICD) candidates to mitigate the risk of ICD-related complications. We designed the CERTAINTY study (CinE
Externí odkaz:
https://doaj.org/article/d2c28ff980a9402c89aa70b1c7a2f382