Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Joannes P. Yuh"'
Autor:
Jason Phan, Olivia W. Rossanese, J.G. Shaw, Chao Han, Leiber Thomas, DeMarco V. Camper, Bin Zhao, Erin R. Aho, S.W. Fesik, Joseph Alvarado, J.A. Bauer, Feng Wang, Bethany M. Alicie, Joannes P. Yuh, Jennifer E. Howes, Jonathan David Macdonald, Sameer Nikhar, Jiqing Sai, William G. Payne, S. Chacon Simon, Alex G. Waterson, Shaun R. Stauffer, William P. Tansey
Publikováno v:
Journal of medicinal chemistry. 62(24)
The treatment of tumors driven by overexpression or amplification of MYC oncogenes remains a significant challenge in drug discovery. Here, we present a new strategy toward the inhibition of MYC via the disruption of the protein-protein interaction b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3674d0595ce1b6e8dc02b864870b3195
https://pubmed.ncbi.nlm.nih.gov/31724864
https://pubmed.ncbi.nlm.nih.gov/31724864
Autor:
Kyu Ok Jeon, Edward T. Olejniczak, Jason Phan, Rocco D. Gogliotti, Shaun R. Stauffer, J. Grace Shaw, Joannes P. Yuh, Joseph Alvarado, Olivia W. Rossanese, Stephen W. Fesik, William P. Tansey, Jiqing Sai, Jonathan David Macdonald, Shi-Dong Wang, Qi Sun, Feng Wang, James M. Salovich, DeMarco V. Camper
Publikováno v:
Journal of medicinal chemistry. 61(13)
WDR5 is a chromatin-regulatory scaffold protein overexpressed in various cancers and a potential epigenetic drug target for the treatment of mixed-lineage leukemia. Here, we describe the discovery of potent and selective WDR5-WIN-site inhibitors usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451315dd292e4c2214fea8519ca5ff8f
https://pubmed.ncbi.nlm.nih.gov/29889518
https://pubmed.ncbi.nlm.nih.gov/29889518
Autor:
Brittney S. Bates, Shaun R. Stauffer, P. Jeffrey Conn, Hilary Highfield Nickols, Joannes P. Yuh, Analisa D. Thompson, Xiaohui Lv, Craig W. Lindsley, J. Scott Daniels, Zixiu Xiang, Colleen M. Niswender, Karen J. Gregory, Kyle A. Emmitte, Michael Bubser, Carrie K. Jones, Ryan D. Morrison, Michael T. Nedelcovych, Weimin Peng
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 356(1)
Negative allosteric modulators (NAMs) of metabotropic glutamate receptor subtype 5 (mGlu5) have potential applications in the treatment of fragile X syndrome, levodopa-induced dyskinesia in Parkinson disease, Alzheimer disease, addiction, and anxiety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107a350a8d4d53c2d21070e3265abcb1
https://pubmed.ncbi.nlm.nih.gov/26503377
https://pubmed.ncbi.nlm.nih.gov/26503377