Lack of high BMI-related features in adipocytes and inflammatory cells in the infrapatellar fat pad (IFP)

Autor: Anja J. de Jong, Inge R. Klein-Wieringa, Stefan N. Andersen, Joanneke C. Kwekkeboom, Linda Herb-van Toorn, Badelog J. E. de Lange-Brokaar, Danny van Delft, John Garcia, Wu Wei, Huub J. L. van der Heide, Yvonne M. Bastiaansen-Jenniskens, Gerjo J. V. M. van Osch, Annemarie M. Zuurmond, Vedrana Stojanovic-Susulic, Rob G. H. H. Nelissen, René E. M. Toes, Margreet Kloppenburg, Andreea Ioan-Facsinay

Publikováno v: Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-12 (2017)

Abstract Background Obesity is associated with the development and progression of osteoarthritis (OA). Although the infrapatellar fat pad (IFP) could be involved in this association, due to its intracapsular localization in the knee joint, there is c

Externí odkaz: https://doaj.org/article/ec74ab8669fe45e4a28ab17c323dcccf

Comparative photoaffinity profiling of omega-3 signaling lipid probes reveals prostaglandin reductase 1 as a metabolic hub in human macrophages

Autor: Berend Gagestein, Johannes H. von Hegedus, Joanneke C. Kwekkeboom, Marieke Heijink, Niek Blomberg, Tom van der Wel, Bogdan I. Florea, Hans van den Elst, Kim Wals, Herman S. Overkleeft, Martin Giera, René E. M. Toes, Andreea Ioan-Facsinay, Mario van der Stelt

Publikováno v: Journal of the American Chemical Society, 144(41), 18938–18947. AMER CHEMICAL SOC
Journal of the American Chemical Society, 144(41), 18938-18947. AMER CHEMICAL SOC

The fish oil constituent docosahexaenoic acid (DHA, 22:6 n-3) is a signaling lipid with anti-inflammatory properties. The molecular mechanisms underlying the biological effect of DHA are poorly understood. Here, we report the design, synthesis, and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575cf860d89184bb92f2de09d9c6c036
https://hdl.handle.net/1887/3513379

Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation

Autor: Theresa Kissel, Changrong Ge, Lise Hafkenscheid, Joanneke C. Kwekkeboom, Linda M. Slot, Marco Cavallari, Yibo He, Karin A. van Schie, Rochelle D. Vergroesen, Arieke S.B. Kampstra, Sanne Reijm, Gerrie Stoeken-Rijsbergen, Carolien Koeleman, Lennard M. Voortman, Laura H. Heitman, Bingze Xu, Ger J.M. Pruijn, Manfred Wuhrer, Theo Rispens, Tom W.J. Huizinga, Hans Ulrich Scherer, Michael Reth, Rikard Holmdahl, Rene E.M. Toes

Publikováno v: Science Advances, 8, 6, pp. 1-21
Science Advances, 8, 1-21
Science advances, 8(6):abm1759. American Association for the Advancement of Science
Kissel, T, Ge, C, Hafkenscheid, L, Kwekkeboom, J C, Slot, L M, Cavallari, M, He, Y, van Schie, K A, Vergroesen, R D, Kampstra, A S B, Reijm, S, Stoeken-Rijsbergen, G, Koeleman, C, Voortman, L M, Heitman, L H, Xu, B, Pruijn, G J M, Wuhrer, M, Rispens, T, Huizinga, T W J, Scherer, H U, Reth, M, Holmdahl, R & Toes, R E M 2022, ' Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation ', Science Advances, vol. 8, no. 6, abm1759 . https://doi.org/10.1126/sciadv.abm1759
Science Advances, 8(6). AMER ASSOC ADVANCEMENT SCIENCE
Science Advances, 8(6), 1-21

The hallmark autoantibodies in rheumatoid arthritis are characterized by variable domain glycans (VDGs). Their abundant occurrence results from the selective introduction of N-linked glycosylation sites during somatic hypermutation, and their presenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0208285deb500549af186c437aedd773
https://repository.ubn.ru.nl/handle/2066/248660

Functional and phenotypical analysis of IL-6-secreting CD4

Autor: Anja J, de Jong, Sabrina, Pollastro, Joanneke C, Kwekkeboom, Stefan N, Andersen, Annemarie L, Dorjée, Aleida M, Bakker, Fawaz, Alzaid, Antoine, Soprani, Rob G H H, Nelissen, Jan B, Mullers, Nicolas, Venteclef, Niek, de Vries, Margreet, Kloppenburg, René E M, Toes, Andreea, Ioan-Facsinay

Publikováno v: European Journal of Immunology

Emerging evidence indicates that a dynamic interplay between the immune system and adipocytes contributes to the disturbed homeostasis in adipose tissue of obese subjects. Recently, we observed IL‐6‐secretion by CD4+ T cells from the stromal vasc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::540e8a5d83c30061d14c4ed2fd6f46f8
https://pubmed.ncbi.nlm.nih.gov/29283192

Oleic acid triggers metabolic rewiring of T cells poising them for T helper 9 differentiation

Autor: Nathalie A. Reilly, Friederike Sonnet, Koen F. Dekkers, Joanneke C. Kwekkeboom, Lucy Sinke, Stan Hilt, Hayat M. Suleiman, Marten A. Hoeksema, Hailiang Mei, Erik W. van Zwet, Bart Everts, Andreea Ioan-Facsinay, J. Wouter Jukema, Bastiaan T. Heijmans

Publikováno v: iScience, Vol 27, Iss 4, Pp 109496- (2024)

Summary: T cells are the most common immune cells in atherosclerotic plaques, and the function of T cells can be altered by fatty acids. Here, we show that pre-exposure of CD4+ T cells to oleic acid, an abundant fatty acid linked to cardiovascular ev

Externí odkaz: https://doaj.org/article/5f40b85a5de4481da650e5538f4737d5