Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Joanne Zeng"'
Publikováno v:
Peptides. 31:130-138
Neuropeptide S (NPS) is the endogenous ligand of a formerly orphan G protein-coupled receptor (GPCR). The NPS receptor (NPSR) belongs to the subfamily of peptide GPCRs and is widely expressed in the brain. NPS promotes arousal and induces anxiolytic-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325f89d98b8bf6bd8e71c52dfebd3147
https://doi.org/10.1016/j.peptides.2009.10.015
https://doi.org/10.1016/j.peptides.2009.10.015
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 325:893-901
Neuropeptide S (NPS) has been shown to modulate arousal, sleep-wakefulness, anxiety-like behavior and feeding after central administration of the peptide agonist to mice or rats. We report here the chemical synthesis and pharmacological characterizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9319c2a35ce4d04613d61821b7bb12ad
https://doi.org/10.1124/jpet.107.135103
https://doi.org/10.1124/jpet.107.135103
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 318:262-267
The neuropeptide orphanin FQ/nociceptin (OFQ/N) has been shown to counteract several effects of endogenous and exogenous opioids, and it has been proposed as an opioid-modulating agent involved in the development of morphine tolerance and dependence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8558a4794f870b8b4aed6797a9c6c5bf
https://doi.org/10.1124/jpet.106.103960
https://doi.org/10.1124/jpet.106.103960
Autor:
Rainer K. Reinscheid, Yan-Ling Xu, Naoe Okamura, Shinjae Chung, Rama Pai, Joanne Zeng, Zhiwei Wang, Olivier Civelli
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 315:1338-1345
We have recently shown that Neuropeptide S (NPS) can promote arousal and induce anxiolytic-like effects after central administration in rodents. Another study reported a number of natural polymorphisms in the human NPS receptor gene. Some of these po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50c94be06d5003571395bc608ea7809
https://doi.org/10.1124/jpet.105.093427
https://doi.org/10.1124/jpet.105.093427
Autor:
Stewart D. Clark, Salvador Huitron-Resendiz, Joanne Zeng, Yan Ling Xu, Rainer K. Reinscheid, Luis de Lecea, Fernando A. Brucher, Olivier Civelli, Steven H.S. Lin, Steven J. Henriksen, Nga Kim Ly, Zhiwei Wang
Publikováno v:
Neuron. 43(4):487-497
Arousal and anxiety are behavioral responses that involve complex neurocircuitries and multiple neurochemical components. Here, we report that a neuropeptide, neuropeptide S (NPS), potently modulates wakefulness and could also regulate anxiety. NPS a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f09062223b5305b7f5e6a16ad95440f
Publikováno v:
European Journal of Pharmacology. 478:27-34
Cyclic adenosine-monophosphate (cAMP) is one of the major second messenger molecules transmitting extracellular stimuli into short- and long-term changes of intracellular homeostasis. Measurements of cellular cAMP levels are often used to quantify an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2319d5a390e5efcf044bf3963a76a8da
https://doi.org/10.1016/j.ejphar.2003.08.036
https://doi.org/10.1016/j.ejphar.2003.08.036
Publikováno v:
The Journal of comparative neurology. 519(10)
Neuropeptide S (NPS) has been associated with a number of complex brain functions, including anxiety-like behaviors, arousal, sleep-wakefulness regulation, drug-seeking behaviors, and learning and memory. In order to better understand how NPS influen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5536c508704e391245430ed300f12f4b
https://pubmed.ncbi.nlm.nih.gov/21452230
https://pubmed.ncbi.nlm.nih.gov/21452230
Autor:
Yan-Ling, Xu, Rainer K, Reinscheid, Salvador, Huitron-Resendiz, Stewart D, Clark, Zhiwei, Wang, Steven H, Lin, Fernando A, Brucher, Joanne, Zeng, Nga K, Ly, Steven J, Henriksen, Luis, de Lecea, Olivier, Civelli
Publikováno v:
Neuron. 43(4)
Arousal and anxiety are behavioral responses that involve complex neurocircuitries and multiple neurochemical components. Here, we report that a neuropeptide, neuropeptide S (NPS), potently modulates wakefulness and could also regulate anxiety. NPS a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9c418d0a59d6945ba1af9d9e166671b
https://pubmed.ncbi.nlm.nih.gov/15312642
https://pubmed.ncbi.nlm.nih.gov/15312642