Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Joanne Y.H. Lim"'
Publikováno v:
Cancer Immunology, Immunotherapy. 63:259-271
The need for an intact immune system for cancer radiation therapy to be effective suggests that radiation not only acts directly on the tumor but also indirectly, through the activation of host immune components. Recent studies demonstrated that endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f06349b1d1ff039d8fe7602a1430a76
https://doi.org/10.1007/s00262-013-1506-7
https://doi.org/10.1007/s00262-013-1506-7
Autor:
Shawn P. Murphy, Nejat K. Egilmez, Joanne Y.H. Lim, Abigail Sedlacek, Kelli A. Connolly, Scott A. Gerber, Margaret L. Barlow, Edith M. Lord
Publikováno v:
International Journal of Cancer. 134:2383-2392
Radiation therapy (RT) continues to be a cornerstone in the treatment for many cancers. Unfortunately, not all individuals respond effectively to RT resulting clinically in two groups consisting of nonresponders (progressive disease) and responders (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40963101b8ca2b5346e142ba1e030faa
https://doi.org/10.1002/ijc.28558
https://doi.org/10.1002/ijc.28558
Autor:
Abigail Sedlacek, Denise Skrombolas, Joanne Y.H. Lim, John G. Frelinger, Scott A. Gerber, Elizabeth W. Sorensen, Edith M. Lord
Publikováno v:
Immunology
The tumour microenvironment is complex containing not only neoplastic cells but also a variety of host cells. The heterogeneous infiltrating immune cells include subsets of cells with opposing functions, whose activities are mediated either directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0985fed5dce449e5bf3e2c3973e33600
Autor:
Dieter Mueller, Pornwaratt Niyomrattanakit, J. Frasier Glickman, Hongping Dong, Min Qing, Zheng Yin, Thomas H. Keller, Hans Voshol, Kai Lin, Joanne Y.H. Lim, Shahul Nilar, Pei Yong Shi, Yen Liang Chen
Publikováno v:
Journal of Virology. 84:5678-5686
Dengue virus (DENV) is the most prevalent mosquito-borne viral pathogen in humans. Neither vaccine nor antiviral therapy is currently available for DENV. We report here that N -sulfonylanthranilic acid derivatives are allosteric inhibitors of DENV RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35a87282c18b8224c152f1b84312701
https://doi.org/10.1128/jvi.02451-09
https://doi.org/10.1128/jvi.02451-09
Autor:
Wai Ling Chan, Bo Zhang, Thomas H. Keller, Wouter Schul, Min Qing, Pei Yong Shi, Andy Yip, Kristen A. Bernard, Gang Zou, Hao Ying Xu, Suresh B. Lakshminarayana, Gang Wang, Anne Goh, Wei Liu, Min Dong, Boping Liu, Hui Pen Tan, Handan He, Qing Yin Wang, Margaret Weaver, Feng Gu, Yen Liang Chen, Zheng Yin, Pornwaratt Niyomrattanakit, Chuan Young Ng, Arkadius Pichota, Christine E. Garrett, Véronique Dartois, Joanne Y.H. Lim, Ravinder Reddy Kondreddi, Jeyaraj Duraiswamy, Kai Lin, Chin Chin Lim, Karen Beltz
Publikováno v:
Proceedings of the National Academy of Sciences. 106:20435-20439
Dengue virus (DENV), a mosquito-borne flavivirus, is a major public health threat. The virus poses risk to 2.5 billion people worldwide and causes 50 to 100 million human infections each year. Neither a vaccine nor an antiviral therapy is currently a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a316c5d40ed9639ddcd32990e5f5a43e
https://doi.org/10.1073/pnas.0907010106
https://doi.org/10.1073/pnas.0907010106
Autor:
Wai Ling Chan, Shahul Nilar, Subhash G. Vasudevan, Wan Yen Lee, Sigmar Dressler, Gang Wang, Pei Yong Shi, Alex Chao, Ru Hui Ng, Hans Voshol, Thomas H. Keller, Daying Wen, Yen Liang Chen, J. Fraser Glickman, Joanne Y.H. Lim, Pornwaratt Niyomrattanakit, Zheng Yin, Ravinder Reddy Kondreddi, Duraiswamy Athisayamani Jeyaraj, Carsten Spanka, Dieter Mueller
Publikováno v:
Journal of Medicinal Chemistry. 52:7934-7937
A novel class of compounds containing N-sulfonylanthranilic acid was found to specifically inhibit dengue viral polymerase. The structural requirements for inhibition and a preliminary structure-activity relationship are described. A UV cross-linking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1534d73bf76116a17290459e8861aca0
https://doi.org/10.1021/jm901044z
https://doi.org/10.1021/jm901044z
Autor:
Feng Gu, L. Alex Gaither, Chuan Young Ng, Mark Labow, Wei Liu, Christopher Rothwell, Subhash G. Vasudevan, Joanne Y.H. Lim, Aude LeBreton
Publikováno v:
Virology. 389(1-2):8-19
We performed a focused siRNA screen in an A549 dengue type 2 New Guinea C subgenomic replicon cell line (Rluc-replicon) that contains a Renilla luciferase cassette. We found that siRNA mediated knock down of mevalonate diphospho decarboxylase (MVD) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7e77fbfdb0d7417fc18edc9e204cb2
Autor:
Y Gao, Anat A. Herskovits, Joanne Y.H. Lim, Adam Sampson-Johannes, David N. Cook, Martin A. Giedlin, John E. Hearst, Keith S. Bahjat, W Liu, William S. Luckett, D Kapadia, A Stassinopoulos, Pamela Schnupf, Thomas W. Dubensky, G Castro, H. G. Archie Bouwer, Dirk G. Brockstedt, M Leong, Daniel A. Portnoy
Publikováno v:
Nature Medicine. 11:853-860
We developed a new class of vaccines, based on killed but metabolically active (KBMA) bacteria, that simultaneously takes advantage of the potency of live vaccines and the safety of killed vaccines. We removed genes required for nucleotide excision r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b50e6b94dcb77d5fbcbc21970260631
https://doi.org/10.1038/nm1276
https://doi.org/10.1038/nm1276
Publikováno v:
Cancer Research. 73:A95-A95
Endogenous type I interferons (IFN-α/β) and interferon gamma (IFN-γ) have both been implicated in immune responses against cancer. Interestingly, studies done using viral infection models have demonstrated that IFN-α/β and IFN-γ play non-redund
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e25ed7107cccb253cb9e907a2e5be4b9
https://doi.org/10.1158/1538-7445.tumimm2012-a95
https://doi.org/10.1158/1538-7445.tumimm2012-a95
Autor:
Michael S. Diamond, Zhihua Kou, Luis Martinez-Sobrido, Martina Beltramello, Xia Jin, Huiyuan Chen, Jacob J. Schlesinger, Aravinda M. de Silva, Shengyong Liu, Federica Sallusto, Joanne Y.H. Lim, Matthew Quinn
Publikováno v:
Virology. (2):320
a Department of Medicine, University of Rochester, Rochester, NY, USA b State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China c Department of Microbiology and Immunology, University of Ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700969372e367bb6ed2bc943fa23dcba