Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Joanne Widom"'
HAMP domains are dimeric, four-helix bundles that transduce conformational signals in bacterial receptors. Genetic studies of the Escherichia coli serine receptor (Tsr) provide an opportunity to understand HAMP conformational behavior in terms of fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5479783ce746d92537d22ffc9562f3
https://europepmc.org/articles/PMC5390053/
https://europepmc.org/articles/PMC5390053/
Autor:
Brian R. Crane, Brian D. Zoltowski, Michael W. Young, Joanne Widom, Anand T. Vaidya, Deniz Top
Publikováno v:
Nature
The cryptochrome/photolyase family of photoreceptors mediates cellular responses to ultraviolet and blue light exposure in all kingdoms of life: cryptochromes transduce signals important for growth, development, magnetosensitivity and circadian clock
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922fe2b08e8bd65c2267bcf82875b095
https://doi.org/10.1038/nature10618
https://doi.org/10.1038/nature10618
Autor:
Bhumit A. Patel, Yuejin Hua, Huan Chen, Brian R. Crane, Longfei Yin, Joanne Widom, Magali Moreau
Publikováno v:
Proceedings of the National Academy of Sciences. 106:18183-18188
Deinococcus radiodurans (Dr) withstands desiccation, reactive oxygen species, and doses of radiation that would be lethal to most organisms. Deletion of a gene encoding a homolog of mammalian nitric oxide synthase (NOS) severely compromises the recov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c52a3f03df568598ce4f4654440c26
https://doi.org/10.1073/pnas.0907262106
https://doi.org/10.1073/pnas.0907262106
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2580-2583
Human methionine aminopeptidase type 2 (hMetAP-2) was identified as the molecular target of anti-angiogenic agents such as fumagillin and its analogues. We describe here the crystal structure of hMetAP-2 in complex with l -methionine and d -methionin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d89f32dadd5876c2480de37385795fcd
https://doi.org/10.1016/j.bmcl.2006.02.047
https://doi.org/10.1016/j.bmcl.2006.02.047
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 62:312-323
Membrane-associated dihydroorotate dehydrogenase (DHODH) is an antimalarial therapeutic target without an effective inhibitor. Studies on human DHODH (HsDHODH) led to a structural mechanistic model in which respiratory quinones bind in a tunnel forme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6174f1beeb92e60f02ef191674a63d
https://doi.org/10.1107/s0907444905042642
https://doi.org/10.1107/s0907444905042642
Autor:
Kimberly D. Cameron, Rosemary Loria, Joanne Widom, Michael J. Wach, Johan A. Kers, Donna M. Gibson, Raghida Bukhalid, Brian R. Crane, Stuart B. Krasnoff
Publikováno v:
Nature. 429:79-82
Nitric oxide (NO) is a potent intercellular signal in mammals that mediates key aspects of blood pressure, hormone release, nerve transmission and the immune response of higher organisms. Proteins homologous to full-length mammalian nitric oxide synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c35f3f4186622e34ce03b8e5bf1bb7c
https://doi.org/10.1038/nature02504
https://doi.org/10.1038/nature02504
Publikováno v:
Journal of Biological Chemistry. 277:17057-17061
Eukaryotic translation initiation factor 2alpha (eIF2alpha) is a member of the eIF2 heterotrimeric complex that binds and delivers Met-tRNA(i)(Met) to the 40 S ribosomal subunit in a GTP-dependent manner. Phosphorylation/dephosphorylation of eIF2alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dadbd1a27e41897a5b8caa4a17f48d2
https://doi.org/10.1074/jbc.m111804200
https://doi.org/10.1074/jbc.m111804200
Publikováno v:
Structure. 7:R263-R267
We would like to thank Wayne Hendrickson for directing our attention to [14xCrystal structure of mouse H2-M. Fremont, D.H., Crawford, F., Marrack, P., Hendrickson, W.A., and Kappler, J. Immunity. 1998; 9: 385–393Abstract | Full Text | Full Text PDF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7801f642c897cb2998ca7603cfc7ae9e
https://doi.org/10.1016/s0969-2126(00)80020-9
https://doi.org/10.1016/s0969-2126(00)80020-9
Autor:
Achim D. Gruber, Randolph C. Elble, Bendicht U. Pauli, Mossaad Abdel-Ghany, Joanne Widom, Hung Chi Cheng, Roy A. Levine, Andrew E. Goodwin
Publikováno v:
Journal of Biological Chemistry. 272:27853-27861
Lung-endothelial cell adhesion molecule-1 (Lu-ECAM-1) is an endothelial cell surface molecule that mediates adhesion of metastatic melanoma cells to lung endothelium. Here we analyze the organization of the Lu-ECAM-1 protein complex, report the seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1548f6d34e4a43a1ebfa4fd1dba1dd
https://doi.org/10.1074/jbc.272.44.27853
https://doi.org/10.1074/jbc.272.44.27853
Autor:
Joanne Widom, Michael V. Airola, Brian R. Crane, Ria Sircar, Kylie J. Watts, Nattakan Sukomon, Peter P. Borbat, Jack H. Freed, Doowon Huh
Publikováno v:
Journal of molecular biology. 425(5)
Bacterial receptors typically contain modular architectures with distinct functional domains that combine to send signals in response to stimuli. Although the properties of individual components have been investigated in many contexts, there is littl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b10d5b49d4ebea5b280c77d822edd4
https://pubmed.ncbi.nlm.nih.gov/23274111
https://pubmed.ncbi.nlm.nih.gov/23274111