Výsledky vyhledávání - "Joanne T. Hulme"

Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain

Autor: Vladimir Yarov-Yarovoy, William A. Catterall, Teddy W.-C. Lin, Joanne T. Hulme, Todd Scheuer

Publikováno v: The Journal of Physiology. 576:87-102

Voltage-gated Ca2+ channels of the CaV1 family initiate excitation–contraction coupling in cardiac, smooth, and skeletal muscle and are primary targets for regulation by the sympathetic nervous system in the ‘fight-or-flight’ response. In the h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e591cbf83ebcd25bdf6b41e0b81935da
https://doi.org/10.1113/jphysiol.2006.111799

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Regulation of cardiac ion channels by signaling complexes: role of modified leucine zipper motifs

Autor: William A. Catterall, Joanne T. Hulme, Todd Scheuer

Publikováno v: Journal of Molecular and Cellular Cardiology. 37:625-631

Modulation of ion channels by protein phosphorylation is a dynamic process precisely controlled by the opposing actions of protein kinases and phosphoprotein phosphatases. It is well accepted that the targeting and localization of such signaling enzy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2e4dd037d4a57f526576c59de41be5
https://doi.org/10.1016/j.yjmcc.2004.04.014

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β-Adrenergic regulation requires direct anchoring of PKA to cardiac Ca V 1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15

Autor: Joanne T. Hulme, Todd Scheuer, Ruth E. Westenbroek, William A. Catterall, Teddy W.-C. Lin

Publikováno v: Proceedings of the National Academy of Sciences. 100:13093-13098

Activation of β-adrenergic receptors and consequent phosphorylation by cAMP-dependent protein kinase A (PKA) greatly increases the L-type Ca 2+ current through Ca V 1.2 channels in isolated cardiac myocytes. A kinase-anchoring protein 15 (AKAP15) co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7a8fa852c21e1ea25e291bcb9d1932
https://doi.org/10.1073/pnas.2135335100

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A Novel Leucine Zipper Targets AKAP15 and Cyclic AMP-dependent Protein Kinase to the C Terminus of the Skeletal Muscle Ca2+ Channel and Modulates Its Function

Autor: William A. Catterall, Joanne T. Hulme, Stephen D. Hauschka, Misol Ahn, Todd Scheuer

Publikováno v: Journal of Biological Chemistry. 277:4079-4087

In skeletal muscle, voltage-dependent potentiation of L-type Ca(2+) channel (Ca(V)1.1) activity requires phosphorylation by cyclic AMP-dependent protein kinase (PKA) anchored via an A kinase-anchoring protein (AKAP15). However, the mechanism by which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4e3d371e79472601aec2ea88e7d942
https://doi.org/10.1074/jbc.m109814200

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Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury

Autor: Jianhua Gong, Roy A. Black, Qing Tian Niu, Hua Z. Ke, Kevin Graham, Efrain Pacheco, James Pretorius, Martine Roudier, Xiaodong Li, Kelly S Warmington, Joanne T. Hulme, Philip Babij, Bo Rin P. Yoon

Publikováno v: Arthritis and rheumatism. 65(3)

Objective Sclerostin plays a major role in regulating skeletal bone mass, but its effects in articular cartilage are not known. The purpose of this study was to determine whether genetic loss or pharmacologic inhibition of sclerostin has an impact on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635525984c68184556a59da65ad51454
https://pubmed.ncbi.nlm.nih.gov/23233270

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Regulation of sodium and calcium channels by signaling complexes

Autor: Xin Jiang, William A. Catterall, Joanne T. Hulme, W. Preston Few

Publikováno v: Journal of receptor and signal transduction research. 26(5-6)

Membrane depolarization and intracellular calcium transients generated by activation of voltage-gated sodium and calcium channels are local signals, which initiate physiological processes such as action potential conduction, synaptic transmission, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203550610a750a2edffaa1afa84f484a
https://pubmed.ncbi.nlm.nih.gov/17118799

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Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during beta1-adrenergic regulation

Autor: Joanne T. Hulme, Todd Scheuer, Ruth E. Westenbroek, William A. Catterall

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 103(44)

During the fight-or-flight response, epinephrine and norepinephrine released by the sympathetic nervous system increase L-type calcium currents conducted by Ca V 1.2a channels in the heart, which contributes to enhanced cardiac performance. Activatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25edfb60fffb1990365678dc62c9fcb3
https://pubmed.ncbi.nlm.nih.gov/17053072

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Sites of proteolytic processing and noncovalent association of the distal C-terminal domain of CaV1.1 channels in skeletal muscle

Autor: David G. Camp, Joanne T. Hulme, William A. Catterall, Marina A. Gritsenko, Teddy W.-C. Lin, Diana J. Bigelow, Keiichi Konoki

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 102(14)

In skeletal muscle cells, voltage-dependent potentiation of Ca 2+ channel activity requires phosphorylation by cAMP-dependent protein kinase (PKA) anchored via an A-kinase anchoring protein (AKAP15), and the most rapid sites of phosphorylation are lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973eca5fec3a902d30b9aae74a2495f7
https://pubmed.ncbi.nlm.nih.gov/15793008

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