Výsledky vyhledávání - "Joanne Speed"

1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors

Autor: Paul Renton, Joanne Speed, Shawn Maddaford, Subhash C. Annedi, Jailall Ramnauth, Suman Rakhit, John Andrews

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:5301-5304

A series of 1,5-disubstituted indole derivatives was designed, synthesized and evaluated as inhibitors of human nitric oxide synthase. A variety of flexible and restricted basic amine side chain substitutions was explored at the 1-position of the ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fdbc0c27580e4d210fe1a3137ba25f1
https://doi.org/10.1016/j.bmcl.2011.07.022

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Design, Synthesis, and Biological Evaluation of 3,4-Dihydroquinolin-2(1H)-one and 1,2,3,4-Tetrahydroquinoline-Based Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors

Autor: Frank Porreca, Subhash C. Annedi, Peter Dove, David H. Lee, Milena De Felice, Gabriela Mladenova, Salvatore Zinghini, Joanne Speed, Concettina Catalano, Jailall Ramnauth, Sheela Nair, Shawn Maddaford, John S. Andrews, Paul Renton, Sarah Silverman, Suman Rakhit

Publikováno v: Journal of Medicinal Chemistry. 54:5562-5575

Neuronal nitric oxide synthase (nNOS) inhibitors are effective in preclinical models of many neurological disorders. In this study, two related series of compounds, 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline, containing a 6-substit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7ffd3f452a96b03ad44d3269cfb826
https://doi.org/10.1021/jm200648s

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Safety and pharmacokinetics of NXN-188 after single and multiple doses in five phase I, randomized, double-blind, parallel studies in healthy adult volunteers

Autor: John S. Andrews, Robert A. Medve, David Vaughan, Joanne Speed

Publikováno v: Scopus-Elsevier

Background : NXN-188 is a dual-action oral therapeutic being developed for the treatment of acute migraine. The mechanism of action of NXN-188 involves inhibition of both the neuronal nitric oxide synthase enzyme isoform and affinity for serotonin (5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7492762da83aa45dfa63424597346478
https://doi.org/10.1016/j.clinthera.2010.01.006

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3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors

Autor: Shawn Maddaford, Joanne Speed, Jailall Ramnauth, Paul Renton, John S. Andrews, Subhash C. Annedi, Frank Porreca, Suman Rakhit

Publikováno v: Bioorganicmedicinal chemistry letters. 22(5)

A series of 3,5-disubstituted indole derivatives was designed, synthesized and evaluated as inhibitors of human nitric oxide synthase (NOS). Various guanidine isosteric groups were explored at the 5-position of the indole ring, while keeping the basi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c4e24d0c2e2a43cae4297d0a2d5e72
https://pubmed.ncbi.nlm.nih.gov/22318159

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1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors

Autor: Shawn Maddaford, Paul Renton, Joanne Speed, Subhash C. Annedi, Jailall Ramnauth, Suman Rakhit, John Andrews, Gabriela Mladenova, Lisa Majuta, Frank Porreca

A series of 1,6-disubstituted indole derivatives was designed, synthesized and evaluated as inhibitors of human nitric oxide synthase (NOS). By varying the basic amine side chain at the 1-position of the indole ring, several potent and selective inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe7b735a4845f92a45652c6b45515f0
https://europepmc.org/articles/PMC5699210/

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