Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Joanne S. Roddick"'
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27666 (2011)
BackgroundVaccine development against malaria and other complex diseases remains a challenge for the scientific community. The recent elucidation of the genome, proteome and transcriptome of many of these complex pathogens provides the basis for rati
Externí odkaz:
https://doaj.org/article/3d934c405da34b8a9af8fe2efbba4415
Publikováno v:
International Journal for Parasitology. 41:1285-1294
Despite significant technological and conceptual advances over the last century, evaluation of the efficacy of anti-malarial vaccines or drugs continues to rely principally on direct microscopic visualisation of parasites on thick and/or thin Giemsa-
Autor:
Joanna N. Radcliffe, Joanne S. Roddick, Freda K. Stevenson, Stephen M. Thirdborough, Peter S. Friedmann
Publikováno v:
The Journal of Immunology. 177:6626-6633
The route for presentation of Ag to CD8+ or CD4+ T cells following DNA vaccination is critical for determining outcome, but the pathways involved are unclear. In this study, we compare two different DNA vaccine designs aimed to elicit CD8+ T cell res
Publikováno v:
Malaria Journal, Vol 11, Iss Suppl 1, p O23 (2012)
Malaria Journal
Malaria Journal
Background Vaccines are considered the most cost-effective public health measure for the prevention of infectious diseases, with many demonstrated successes. However the Plasmodium parasite, causative agent of malaria, has eluded decades of efforts a
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 179(12)
After priming, naive T cells undergo a program of expansion, contraction, and memory formation. Numerous studies have indicated that only a brief period of antigenic stimulation is required to fully commit CD8+ T cells to this program. Nonetheless, t
Autor:
Freda K. Stevenson, Natalia Savelyeva, Christian H. Ottensmeier, Sarah L. Buchan, Andrew T. King, Joanne S. Roddick, Feargal McNicholl, Delin Zhu, Jason Rice, Peter Johnson, Katy J. McCann
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 101
Delivery of antigens by injection of the encoding DNA allows access to multiple antigen-presenting pathways. Knowledge of immunological processes can therefore be used to modify construct design to induce selected effector functions. Expression can b
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27666 (2011)
PLoS ONE
PLoS ONE
BackgroundVaccine development against malaria and other complex diseases remains a challenge for the scientific community. The recent elucidation of the genome, proteome and transcriptome of many of these complex pathogens provides the basis for rati