Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Joanne Petrin"'
Autor:
Alan K. Mallams, Randall R. Rossman, Ronald J. Doll, Viyyoor M. Girijavallabhan, Ashit K. Ganguly, Joanne Petrin, Lynn Wang, Robert Patton, W. Robert Bishop, Donna M. Carr, Paul Kirschmeier, Joseph J. Catino, Matthew S. Bryant, Kwang-Jong Chen, Walter A. Korfmacher, Cymbelene Nardo, Shiyong Wang, Amin A. Nomeir, Chin-Chung Lin, Zujun Li, Jianping Chen, Suining Lee, Janet Dell, Philip Lipari, Michael Malkowski, Bodan Yaremko, Ivan King, Ming Liu
Publikováno v:
Journal of Medicinal Chemistry. 41:877-893
The synthesis of a variety of novel 4-amido, 4-carbamoyl and 4-carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine to explore the SAR of of this series of FPT inhibitors is described. This result
Autor:
W. Robert Bishop, Richard Bond, Joanne Petrin, Lynn Wang, Robert Patton, Ronald Doll, George Njoroge, Joseph Catino, Jerome Schwartz, William Windsor, Rosalinda Syto, Jeffrey Schwartz, Donna Carr, Linda James, Paul Kirschmeier
Publikováno v:
Journal of Biological Chemistry. 270:30611-30618
Ras protooncogenes encode 21-kDa membrane-associated guanine nucleotide-binding proteins, which play a critical role in control of cellular proliferation and differentiation. Oncogenic, activated forms of Ras proteins are associated with a broad rang