Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Joanne Pardoe"'
Autor:
Marie L. Woolley, Lee A. Dawson, Elisa Ballini, Kerry A. Waters, Mark H Harries, Laura Aldegheri, Simon E. Ward, Joanne Pardoe, Laurent Lacroix, John R. Atack, Kathryn R. Starr, Annette Weil, Andrea M. Bradford
Publikováno v:
J Psychopharmacol
Purpose: There is considerable interest in positive allosteric modulators (PAMs) of the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) subtype of ionotropic glutamate receptors as therapeutic agents for a range of cognitive and mood disor
Autor:
Novella Calcinaghi, Declan N.C. Jones, Laurent Lacroix, Lee A. Dawson, M. H. Selina Mok, Kathryn R. Starr, Jane Gartlon, Joanne Pardoe, Francesca Graziani, Mark H Harries, Simon E. Ward, Marie L. Woolley, Paul John Beswick, Beatrice Oliosi
Publikováno v:
British Journal of Pharmacology. 174:370-385
Background and Purpose AMPA receptor positive allosteric modulators represent a potential therapeutic strategy to improve cognition in people with schizophrenia. These studies collectively constitute the preclinical pharmacology data package used to
Autor:
Simon E, Ward, Paul, Beswick, Novella, Calcinaghi, Lee A, Dawson, Jane, Gartlon, Francesca, Graziani, Declan N C, Jones, Laurent, Lacroix, M H, Selina Mok, Beatrice, Oliosi, Joanne, Pardoe, Kathryn, Starr, Marie L, Woolley, Mark H, Harries
Publikováno v:
British journal of pharmacology. 174(5)
AMPA receptor positive allosteric modulators represent a potential therapeutic strategy to improve cognition in people with schizophrenia. These studies collectively constitute the preclinical pharmacology data package used to build confidence in the
Publikováno v:
European Journal of Neuroscience. 35:539-549
The present study uses a double retrograde tracer technique in rats to examine the spatial localization and pattern of axonal branching in mossy fibres arising from three major sources in the medulla-the external cuneate nucleus, the sensory trigemin
Autor:
Christopher J. Langmead, Vincenzo Garzya, Joanne Pardoe, Ralph A. Rivero, Jeannette M. Watson, Ben Tehan, Ian Thomson Forbes, Jian Jin, Adam J. Lucas, Dongchuan Shi, Marie Woolley-Roberts, Zining Wu, Brian Budzik, Graham Walker
Publikováno v:
ACS Medicinal Chemistry Letters. 1:244-248
Virtual screening of the corporate compound collection yielded compound 1 as a subtype selective muscarinic M1 receptor agonist hit. Initial optimization of the N-capping group of the central piperidine ring resulted in compounds 2 and 3 with signifi
Autor:
Ceri H. Davies, Adrianna Teriakidis, Anita K. Roopun, James N.C. Kew, Andrew D. Randall, Zining Wu, Hugh J. Herdon, Jon T. Brown, Ross Jeggo, Nisha Patel, Ian Thomson Forbes, Clive Leslie Branch, Gareth A. Jones, Miles A. Whittington, Victoria Anne Honey Fry, Nigel E. Austin, Martyn D. Wood, Rosemary A. Melarange, Katherine A. Buchanan, Joanne Pardoe, Christopher J. Langmead, Claire Roberts, Kathryn R. Starr, Angelica Mazzali, Jeannette M. Watson, Jim J. Hagan
Publikováno v:
British Journal of Pharmacology. 154:1104-1115
Background and purpose: M1 muscarinic ACh receptors (mAChRs) represent an attractive drug target for the treatment of cognitive deficits associated with diseases such as Alzheimer's disease and schizophrenia. However, the discovery of subtype-selecti
Publikováno v:
The Journal of Neuroscience. 24:2656-2666
The inferior olive climbing fiber projection plays a central role in all major theories of cerebellar function. Therefore, mechanisms that control the ability of climbing fibers to forward information to the cerebellum are of considerable interest. W
Autor:
Joanne Pardoe, Richard Apps
Publikováno v:
The Cerebellum. 1:165-184
The somatotopical organization of the climbing fiber input to the paravermal region of lobulus simplex (LS, lobule Vla) was charted in the cerebellar cortex of anaesthetized rats. From medial to lateral in LS, zones a2, c1, c2 and c3 were identified.
Publikováno v:
Brain. 123:2264-2272
An H reflex conditioning technique was used to monitor the transmission of heteronymous recurrent inhibition from soleus to quadriceps motor neurones of the human lower limb. Inhibition declined during quadriceps muscle contraction under all conditio
Autor:
Joanne Pardoe, J. F. Iles
Publikováno v:
Brain. 122:1757-1764
H reflexes were induced in the human quadriceps muscle by electrical stimulation of the femoral nerve. The reflexes were conditioned by prior stimulation of the inferior soleus nerve. The conditioning stimulus produced an inhibition of long duration