Výsledky vyhledávání - "Joanne P. Marsh"

Mineralogical Features Associated with Cytotoxic and Proliferative Effects of Fibrous Talc and Asbestos on Rodent Tracheal Epithelial and Pleural Mesothelial Cells

Autor: H. Snyder, Brooke T. Mossman, C. Garzione, Joanne P. Marsh, Ann G. Wylie, R. Winters, D. Hodkinson, H. C. W. Skinner

Publikováno v: Toxicology and Applied Pharmacology. 147:143-150

Inhalation of asbestos fibers causes cell damage and increases in cell proliferation in various cell types of the lung and pleura in vivo. By using a colony-forming efficiency (CFE) assay, the cytotoxicity and proliferative potential of three mineral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0050f8425bd64424176f1ed090d54252
https://doi.org/10.1006/taap.1997.8276

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Transfection of a manganese-containing superoxide dismutase gene into hamster tracheal epithelial cells ameliorates asbestos-mediated cytotoxicity

Autor: Nicholas H. Heintz, Joanne P. Marsh, Piyawan Surinrut, Bradford T. Brinton, Brooke T. Mossman, Barbara Lindau-Shepard, Jacquelin B. Shaffer

Publikováno v: Free Radical Biology and Medicine. 21:125-131

To determine if overexpression of manganese-containing SOD (MnSOD) alters cell sensitivity to asbestos, an expression cassette containing murine MnSOD cDNA was cotransfected with pSV2neo, a plasmid conferring resistance to the antibiotic G418, into a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3cf7b165818c237aee1d581fe6d7df4
https://doi.org/10.1016/0891-5849(96)00014-7

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Dose-responsive increases in pulmonary fibrosis after inhalation of asbestos

Autor: Joanne P. Marsh, David R. Hemenway, Brooke T. Mossman, Timothy R. Quinlan, Pamela M. Vacek, Yvonne M. W. Janssen, Kevin O. Leslie

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 150:200-206

We focused here on steady-state mRNA levels of genes involved in antioxidant defense, i.e., manganese superoxide dismutase and copper-zinc superoxide dismutase, and in cell proliferation, i.e., ornithine decarboxylase, c-jun, and glyceraldehyde-3-pho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e3e152205a5ec0e748197ec5b0650f
https://doi.org/10.1164/ajrccm.150.1.8025751

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Oxidant stress responses in human pleural mesothelial cells exposed to asbestos

Autor: Paul J. A. Borm, Yvonne M. W. Janssen, E. Gabrielson, Marlene Absher, Kevin E. Driscoll, Brooke T. Mossman, Joanne P. Marsh

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 149:795-802

The generation of oxidants is a proposed mechanism of cell injury by asbestos fibers. To determine whether human pleural mesothelial cells (HMC) respond to asbestos and active oxygen species (AOS) by induction of antioxidant enzymes, cells obtained f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d193a3d1102dfb10b884e47933ee5d9
https://doi.org/10.1164/ajrccm.149.3.8118652

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Increased expression of manganese-containing superoxide dismutase in rat lungs after inhalation of inflammatory and fibrogenic minerals

Autor: Yvonne M. W. Janssen, Kevin E. Driscoll, Günter Oberdörster, Joanne P. Marsh, Paul J. A. Borm, Brooke T. Mossman

Publikováno v: Free Radical Biology and Medicine. 16:315-322

Steady-state mRNA levels and immunoreactive protein for manganese-containing superoxide dismutase (MnSOD) were assayed in rat lungs after subchronic inhalation of the fibrogenic silicon dioxide, cristobalite, or preparations of titanium dioxide (TiO2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81921a4c37da97ac29bdac3a62ab4b34
https://doi.org/10.1016/0891-5849(94)90032-9

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Effects of Aramid, a high Strength Synthetic Fiber, on Respiratory Cells in Vitro

Autor: Joanne P. Marsh, P. J. A. Borm, Brooke T. Mossman, Kevin E. Driscoll, R. F. Schins

Publikováno v: Drug and Chemical Toxicology. 17:75-92

Industry continues to develop synthetic fibers for new technologies and as replacements for asbestos, a toxic and carcinogenic fiber. To determine whether the in vitro effects of the aromatic polyamide fiber, Aramid (Kevlar, Twaron), resembled those

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f081649c075e6190ebdbfe5a4ecc3c1
https://doi.org/10.3109/01480549409014303

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Oxygen radicals and asbestos-mediated disease

Autor: Joanne P. Marsh, Paul J. A. Borm, Brooke T. Mossman, Timothy R. Quinlan, Yvonne M. W. Janssen

Publikováno v: Environmental Health Perspectives

Asbestos fibers are potent elaborators of active oxygen species whether by reactions involving iron on the surface of the fiber, or by attempted phagocytosis of fibers by cell types resident in the lung. The link between production of active oxygen s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b3c998620d61563c83b90aaa5c9e4c
http://europepmc.org/articles/PMC1566980

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Expression of antioxidant enzymes in rat lungs after inhalation of asbestos or silica

Autor: Pamela M. Vacek, Joanne P. Marsh, Kevin O. Leslie, David R. Hemenway, Marlene Absher, Brooke T. Mossman, P. J. A. Borm, Yvonne W. M. Janssen

Publikováno v: Journal of Biological Chemistry. 267:10625-10630

Several studies indicate that active oxygen species play an important role in the development of pulmonary disease (asbestosis and silicosis) after exposure to mineral dust. The present study was conducted to determine if inhaled fibrogenic minerals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b516d3a5da54d056a83c370302fa95b8
https://doi.org/10.1016/s0021-9258(19)50063-1

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Differential regulation of antioxidant enzymes in response to oxidants

Autor: Yvonne W. M. Janssen, Muthu Periasamy, Joanne P. Marsh, S. Shull, Nicholas H. Heintz, Brooke T. Mossman, M. Manohar

Publikováno v: Journal of Biological Chemistry. 266:24398-24403

We have demonstrated the selective induction of manganese superoxide dismutase (MnSOD) or catalase mRNA after exposure of tracheobronchial epithelial cells in vitro to different oxidant stresses. Addition of H2O2 caused a dose-dependent increase in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f6963c48678487e6bd46cc93da379ea
https://doi.org/10.1016/s0021-9258(18)54242-3

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Inhibition of Lung Injury, Inflammation, and Interstitial Pulmonary Fibrosis by Polyethylene Glycol-conjugated Catalase in a Rapid Inhalation Model of Asbestosis

Autor: Marie A. Shatos, Scot Hill, Ann Sesko, Kenneth B. Adler, Pamela M. Vacek, Elliott Kagan, Brooke T. Mossman, Janet M. Petruska, Jacqueline M. Doherty, Joanne P. Marsh, David R. Hemenway, Ruth M. Mickey

Publikováno v: American Review of Respiratory Disease. 141:1266-1271

Several in vitro studies suggest the involvement of active oxygen metabolites in cell damage caused by asbestos. To determine if lung injury, inflammation, and asbestosis could be inhibited in vivo in a rapid-onset, inhalation model of disease, a nov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e62476aff989d233c61ccdc69cc0c3
https://doi.org/10.1164/ajrccm/141.5_pt_1.1266

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