Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Joanne O. Wiseman"'
Autor:
Margarete Neu, Christopher David Edlin, J. Nicole Hamblin, Yemisi E. Solanke, Christopher J. Delves, Mika Kristian Lindvall, Don O. Somers, Michael Kranz, Caroline Mary Cook, Diane M. Coe, Sue E. Keeling, Naimisha Trivedi, Stuart Holman, Joanne O. Wiseman, Charlotte Jane Mitchell, Paul Spencer Jones, Fiona S. Lucas, Mike D. Dowle, Stuart P. Ballantine, Martin R. Johnson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5803-5806
Following the discovery of 4-(substituted amino)-1-alkyl-pyrazolo[3,4-b]pyridine-5-carboxamides as potent and selective phosphodiesterase 4B inhibitors, [Hamblin, J. N.; Angell, T.; Ballentine, S., et al. Bioorg. Med. Chem. Lett. 2008, 18, 4237] the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3b0ac83bb727024a52dbe5216abdd8
https://doi.org/10.1016/j.bmcl.2010.07.136
https://doi.org/10.1016/j.bmcl.2010.07.136
Autor:
Joanne O. Wiseman, Richard G. Knowles, Patricia L. Podolin, Doug Ball, Jen-Pyng Kou, Fiona S. Lucas, Paul Bryan Wren, John J. Peterson, Mary S. Barnette, Livia Ferrari, T. Gregg Davis, Richard A. Williamson, Anthony T. Nials, Elizabeth A. Capper-Spudich, Yemisi E. Solanke
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 330:922-931
Clinical utility of phosphodiesterase 4 (PDE4) inhibitors as anti-inflammatory agents has, to date, been limited by adverse effects including nausea and emesis, making accurate assessment of emetic versus anti-inflammatory potencies critical to the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab5d6de430cda26fe55b15cd754bffd6
https://doi.org/10.1124/jpet.109.152454
https://doi.org/10.1124/jpet.109.152454
Autor:
John Dawson, Michael David Barker, Stuart Holman, Joanne O. Wiseman, Margarete Neu, Lisa E. Ranshaw, Fiona S. Lucas, Duncan S. Holmes, Michael Kranz, Christopher J. Delves, Beth J. Clarke, Woodrow Michael David, Tony W. Dean, Don O. Somers, Steven B. Guntrip, Stuart P. Ballantine, Yemisi E. Solanke, Mika K. Lindvaal, Sharon Lisa Gough, Brian Evans, Ward Peter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1380-1385
Crystallography driven optimisation of a lead derived from similarity searching of the GSK compound collection resulted in the discovery of quinoline-3-carboxamides as highly potent and selective inhibitors of phosphodiesterase 4B. This series has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d1b7e1eca93eb6425d855b2b8ac1a8
https://doi.org/10.1016/j.bmcl.2009.01.045
https://doi.org/10.1016/j.bmcl.2009.01.045
Autor:
Michael D. Woodrow, Stuart P. Ballantine, Michael D. Barker, Beth J. Clarke, John Dawson, Tony W. Dean, Christopher J. Delves, Brian Evans, Sharon L. Gough, Steven B. Guntrip, Stuart Holman, Duncan S. Holmes, Michael Kranz, Mika K. Lindvaal, Fiona S. Lucas, Margarete Neu, Lisa E. Ranshaw, Yemisi E. Solanke, Don O. Somers, Peter Ward, Joanne O. Wiseman
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(17)
Crystallography driven optimisation of a lead derived from similarity searching of the GSK compound collection resulted in the discovery of quinoline-3-carboxamides as highly potent and selective inhibitors of phosphodiesterase 4B. This series has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183db6b3496dd28055dbc18b1fc971c2
https://pubmed.ncbi.nlm.nih.gov/19656678
https://pubmed.ncbi.nlm.nih.gov/19656678
Autor:
Fiona S. Lucas, Helen Susanne Price, John Andrew Corfield, Graham Webb, Steve B. Guntrip, Sean J. Hindley, Alan Naylor, Robert Gleave, Neil Mathews, C. Bountra, Hazel Player, Paul F. Lambeth, Richard M. Hall, Ian B. Campbell, Terry Brown, Andrew P. Blackaby, Joanne O. Wiseman, Kerry Browning, Paul John Beswick, Phillip J. Sidebottom, Nicholas L. Taylor
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
Many years of work have been invested in the identification of potent and selective COX-2 inhibitors for the treatment of chronic inflammatory pain. One issue faced by workers is the balance between the lipophilicity required for potent enzyme inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd1e9f86b785b7810d1398cc8a17706
https://pubmed.ncbi.nlm.nih.gov/19523822
https://pubmed.ncbi.nlm.nih.gov/19523822
Autor:
Paul F. Lambeth, Fiona S. Lucas, Richard Howard Green, Martin E. Swarbrick, Jeremy John Payne, Lee William Page, Malcolm Clive Carter, Paul John Beswick, Alexander J. Stevens, Sharon C Stratton, Neil Anthony Pegg, John Skidmore, Savvas Kleanthous, Alastair J. Stuart, Sue D. Collins, Sharon Bingham, John Andrew Corfield, Richard Stocker, Joanne O. Wiseman, C. David Hartley, Helen Susanne Price, Neil Mathews, Laura J. Chambers, Iain P. Chessell, Robert Gleave, Nick M. Clayton, Alan Naylor, C. Bountra
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
A novel series of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidine-based cyclooxygenase-2 (COX-2) inhibitors, which have a different arrangement of substituents compared to the more common 1,2-diarylheterocycle based molecules, have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadff8d23a6fefccadd5166b5ed7fd16
https://pubmed.ncbi.nlm.nih.gov/19520573
https://pubmed.ncbi.nlm.nih.gov/19520573
Autor:
Charlotte Jane Mitchell, Lisa E. Ranshaw, Tony D. Angell, Mika Kristian Lindvall, Margarete Neu, Christopher J. Delves, Anthony William James Cooper, Caroline Mary Cook, Joanne O. Wiseman, J. Nicole Hamblin, Yemisi E. Solanke, Stuart P. Ballantine, Don O. Somers, John Dawson, Fiona S. Lucas, Paul Spencer Jones
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(14)
Optimisation of a high-throughput screening hit resulted in the discovery of 4-(substituted amino)-1-alkyl-pyrazolo[3,4-b]pyridine-5-carboxamides as potent and selective inhibitors of Phosphodiesterase 4 (PDE4). Herein, we describe early SAR studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0985ea9dab8c311284f5cfc96cf7ce6c
https://pubmed.ncbi.nlm.nih.gov/18539455
https://pubmed.ncbi.nlm.nih.gov/18539455
Autor:
Hazel Player, John Andrew Corfield, Iain P. Chessell, Helen Susanne Price, Sharon C Stratton, Stephen Barry Guntrip, Neil Anthony Pegg, Elizabeth Pickup, Sue D. Collins, Terry Brown, Paul F. Lambeth, Kerry Browning, Sharon Bingham, Paul John Beswick, Alan Naylor, C. Bountra, Claudine Haslam, Ian B. Campbell, Nick M. Clayton, Alexander J. Stevens, Graham Murkit, Fiona S. Lucas, Joanne O. Wiseman, Neil Mathews
Publikováno v:
Bioorganic and medicinal chemistry letters. 14(21)
GW406381 (8), currently undergoing clinical evaluation for the treatment of inflammatory pain is a member of a novel series of 2,3-diaryl-pyrazolo[1,5-b]pyridazine based cyclooxygenase-2 (COX-2) inhibitors, which have been shown to be highly potent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a5ae5555aa18e5a52bb7cab6ccbcda
http://ora.ox.ac.uk/objects/uuid:3e532779-2daa-4502-8039-5bf9c48950ea
http://ora.ox.ac.uk/objects/uuid:3e532779-2daa-4502-8039-5bf9c48950ea
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 44(6)
A range of NSAIDs and reported Cox 2 selective compounds were tested in human freshly isolated platelets and LPS-stimulated mononuclear cells to determine their potency and selectivity as inhibitors of constitutive (presumably Cox 1) and inducible (p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342c2c55e6889238b628641900197d1d
https://pubmed.ncbi.nlm.nih.gov/7583521
https://pubmed.ncbi.nlm.nih.gov/7583521