Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Joanne N, Engel"'
Autor:
Khavong Pha, Kathleen Mirrashidi, Jessica Sherry, Cuong Joseph Tran, Clara M. Herrera, Eleanor McMahon, Cherilyn A. Elwell, Joanne N. Engel
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114624- (2024)
Summary: Chlamydia trachomatis, a leading cause of bacterial sexually transmitted infections, creates a specialized intracellular replicative niche by translocation and insertion of a diverse array of effectors (Incs [inclusion membrane proteins]) in
Externí odkaz:
https://doaj.org/article/709d8d9afe1a44dab1da962683c26d10
Two antagonistic response regulators control Pseudomonas aeruginosa polarization during mechanotaxis
Autor:
Marco J Kühn, Henriette Macmillan, Lorenzo Talà, Yuki Inclan, Ramiro Patino, Xavier Pierrat, Zainebe Al‐Mayyah, Joanne N Engel, Alexandre Persat
Publikováno v:
The EMBO Journal. 42
The opportunistic pathogen Pseudomonas aeruginosa adapts to solid surfaces to enhance virulence and infect its host. Type IV pili (T4P), long and thin filaments that power surface-specific twitching motility, allow single cells to sense surfaces and
Autor:
Marco J. Kühn, Henriette Macmillan, Lorenzo Talà, Yuki Inclan, Ramiro Patino, Xavier Pierrat, Zainebe Al-Mayyah, Joanne N. Engel, Alexandre Persat
The opportunistic pathogenPseudomonas aeruginosaadapts to solid surfaces to enhance virulence and infect its host. Type IV pili (T4P), long and thin filaments that power surface-specific twitching motility, allow single cells to mechanosense surfaces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2907b4b2e1319763a0288db2a2054a0a
https://doi.org/10.1101/2022.11.15.516588
https://doi.org/10.1101/2022.11.15.516588
Autor:
Cherilyn A Elwell, Nadine Czudnochowski, John von Dollen, Jeffrey R Johnson, Rachel Nakagawa, Kathleen Mirrashidi, Nevan J Krogan, Joanne N Engel, Oren S Rosenberg
Publikováno v:
eLife, Vol 6 (2017)
Chlamydia trachomatis is an obligate intracellular pathogen that resides in a membrane-bound compartment, the inclusion. The bacteria secrete a unique class of proteins, Incs, which insert into the inclusion membrane and modulate the host-bacterium i
Externí odkaz:
https://doaj.org/article/049276e2071344c0be3dccf4f86b7824
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171406 (2017)
Infection of human cells with Yersinia pseudotuberculosis expressing a functional type III secretion system (T3SS) leads to activation of host NF-κB. We show that the Yersinia T3SS activates distinct NF-κB pathways dependent upon bacterial subcellu
Externí odkaz:
https://doaj.org/article/989e23cf033a4f0dae2187fc3de56355
Autor:
Cindy S Tran, Stephanie M Rangel, Henrik Almblad, Arlinet Kierbel, Michael Givskov, Tim Tolker-Nielsen, Alan R Hauser, Joanne N Engel
Publikováno v:
PLoS Pathogens, Vol 10, Iss 11, p e1004479 (2014)
Clinical infections by Pseudomonas aeruginosa, a deadly Gram-negative, opportunistic pathogen of immunocompromised hosts, often involve the formation of antibiotic-resistant biofilms. Although biofilm formation has been extensively studied in vitro o
Externí odkaz:
https://doaj.org/article/da0f0ab373fe42d69ec55b1994d4c986
Autor:
Marco J, Kühn, Lorenzo, Talà, Yuki F, Inclan, Ramiro, Patino, Xavier, Pierrat, Iscia, Vos, Zainebe, Al-Mayyah, Henriette, Macmillan, Jose, Negrete, Joanne N, Engel, Alexandre, Persat
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Single cells across kingdoms of life explore, prey, escape, or congregate using surface-specific motility. Motile eukaryotic cells use chemotaxis to direct migration on surfaces. However, how bacteria control surface motility remains und
Autor:
Gary E. Heussler, Oren S. Rosenberg, Melanie R. Silvis, Alan D. Grossman, Rachel J. Dutton, Byoung-Mo Koo, Cameron C. Hearne, Carol A. Gross, Jason M. Peters, Joanne N. Engel, Hendrik Osadnik, Joseph E. Peters, Ramiro Patino, Jiuxin Qu, M. Michael Harden, Candy H. S. Lu, Yuki F. Inclan, John S. Hawkins
Publikováno v:
Nature Microbiology. 4:244-250
The vast majority of bacteria, including human pathogens and microbiome species, lack genetic tools needed to systematically associate genes with phenotypes. This is the major impediment to understanding the fundamental contributions of genes and gen
Publikováno v:
Biochemical and Biophysical Research Communications. 505:1070-1076
Chlamydia trachomatis is an obligate intracellular bacterium that replicates within a membranous compartment, the inclusion, in host cells. Its intracellular life cycle requires host sphingolipids, which are in part acquired through the ER-Golgi loca
Autor:
Alejandro Cabrera-Cortez, Annalyse Lalljie, Karen Hug, Hanh Lam, Jessica Sherry, Victoria Auerbuch, R. Scott Lokey, Joanne N. Engel, Tannia Lau, Adam Lentz
Publikováno v:
Antimicrobial Agents and Chemotherapy
Antibiotic-resistant bacteria are an emerging global health threat. New antimicrobials are urgently needed. The injectisome type III secretion system (T3SS), required by dozens of Gram-negative bacteria for virulence but largely absent from nonpathog