Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Joanne M. Wroblewski"'
Autor:
Myung-Hee Kim, Maria C. de Beer, Joanne M. Wroblewski, Richard J. Charnigo, Ailing Ji, Nancy R. Webb, Frederick C. de Beer, Deneys R. van der Westhuyzen
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 6, Pp 969-979 (2016)
The acute phase (AP) reactant serum amyloid A (SAA), an HDL apolipoprotein, exhibits pro-inflammatory activities, but its physiological function(s) are poorly understood. Functional differences between SAA1.1 and SAA2.1, the two major SAA isoforms, a
Externí odkaz:
https://doaj.org/article/ca6c55289eda4979a22bdd5cd618141a
Autor:
Ailing Ji, Joanne M. Wroblewski, Lei Cai, Maria C. de Beer, Nancy R. Webb, Deneys R. van der Westhuyzen
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 3, Pp 446-455 (2012)
To study the mechanisms of hepatic HDL formation, we investigated the roles of ABCA1, ABCG1, and SR-BI in nascent HDL formation in primary hepatocytes isolated from mice deficient in ABCA1, ABCG1, or SR-BI and from wild-type (WT) mice. Under basal co
Externí odkaz:
https://doaj.org/article/15229931f61349719601eef33e497f33
Autor:
Joanne M. Wroblewski, Anisa Jahangiri, Ailing Ji, Frederick C. de Beer, Deneys R. van der Westhuyzen, Nancy R. Webb
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 12, Pp 2255-2261 (2011)
Inflammation is associated with significant decreases in plasma HDL-cholesterol (HDL-C) and apoA-I levels. Endothelial lipase (EL) is known to be an important determinant of HDL-C in mice and in humans and is upregulated during inflammation. In this
Externí odkaz:
https://doaj.org/article/6f87684bbe834b53bb13ad8436ed1eb6
Autor:
Maria C. de Beer, Nancy R. Webb, Joanne M. Wroblewski, Victoria P. Noffsinger, Debra L. Rateri, Ailing Ji, Deneys R. van der Westhuyzen, Frederick C. de Beer
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 11, Pp 3117-3125 (2010)
Serum amyloid A (SAA) is an acute-phase protein mainly associated with HDL. To study the role of SAA in mediating changes in HDL composition and metabolism during inflammation, we generated mice in which the two major acute-phase SAA isoforms, SAA1.1
Externí odkaz:
https://doaj.org/article/432c2f346959426a9e8d1f8df95209ca
Autor:
Maria C. de Beer, Joanne M. Wroblewski, Victoria P. Noffsinger, Ailing Ji, Jason M. Meyer, Deneys R. van der Westhuyzen, Frederick C. de Beer, Nancy R. Webb
Publikováno v:
Journal of Lipids, Vol 2013 (2013)
Studies suggest that inflammation impairs reverse cholesterol transport (RCT). We investigated whether serum amyloid A (SAA) contributes to this impairment using an established macrophage-to-feces RCT model. Wild-type (WT) mice and mice deficient in
Externí odkaz:
https://doaj.org/article/12f984bbd7654ef08e061ae956f508b7
Autor:
Richard Charnigo, Nancy R. Webb, Joanne M. Wroblewski, Deneys R. van der Westhuyzen, Frederick C. de Beer, Ailing Ji, Myung Hee Kim, Maria C. de Beer
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 6, Pp 969-979 (2016)
The acute phase (AP) reactant serum amyloid A (SAA), an HDL apolipoprotein, exhibits pro-inflammatory activities, but its physiological function(s) are poorly understood. Functional differences between SAA1.1 and SAA2.1, the two major SAA isoforms, a
Autor:
William M. Bailey, Jassir Witta, Preetha Shridas, Alan Daugherty, Victoria P. Noffsinger, Frederick C. de Beer, Anju Balakrishnan, Debra L. Rateri, Ailing Ji, Joanne M. Wroblewski, Richard Charnigo, Deborah A. Howatt, Nancy R. Webb, Maria C. de Beer
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35:1156-1165
Objective— Rupture of abdominal aortic aneurysm (AAA), a major cause of death in the aged population, is characterized by vascular inflammation and matrix degradation. Serum amyloid A (SAA), an acute-phase reactant linked to inflammation and matrix
Impact of Phospholipid Transfer Protein on Nascent High-Density Lipoprotein Formation and Remodeling
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34:1910-1916
Objective— Phospholipid transfer protein (PLTP), which binds phospholipids and facilitates their transfer between lipoproteins in plasma, plays a key role in lipoprotein remodeling, but its influence on nascent high-density lipoprotein (HDL) format
Autor:
Anju Balakrishnan, Joanne M. Wroblewski, Debra L. Rateri, Victoria P. Noffsinger, Alan Daugherty, Deborah A. Howatt, Ailing Ji, Deneys R. van der Westhuyzen, Joel C. Thompson, Lisa R. Tannock, Nancy R. Webb, Frederick C. de Beer, Preetha Shridas, Maria C. de Beer
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34:255-261
Objective— Although elevated plasma concentrations of serum amyloid A (SAA) are associated strongly with increased risk for atherosclerotic cardiovascular disease in humans, the role of SAA in the pathogenesis of lesion formation remains obscure. O
Publikováno v:
Cytokine. 61:506-512
SAA has been shown to have potential proinflammatory properties in inflammatory diseases such as atherosclerosis. These include induction of tumor necrosis factor α, interleukin-6, and monocyte chemoattractant protein 1 in vitro. However, concern ha