Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Joanne M. Upston"'
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 7, Pp 1082-1088 (2001)
15-Lipoxygenase (15-LO)-induced oxidation of lipids in human LDL may be pro-atherogenic. However, the extent to which 15-LO promotes enzymatic oxidation of esterified (i.e., major) lipids in LDL may depend on various factors. Here, we show that overa
Externí odkaz:
https://doaj.org/article/c8174a20196f450891651d8b3300373b
Publikováno v:
Biochemical Journal. 363:753-760
Oxidative modification of low-density lipoproteins in the arterial wall is a key feature of atherogenesis and widely believed to cause and/or accelerate lesion development. Linked to this is the expectation that vascular antioxidants are depleted dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9be608aa32c802d33fc0f2392aaf5f73
https://doi.org/10.1042/bj3630753
https://doi.org/10.1042/bj3630753
Autor:
Hongjie Wang, Anthony J. Kettle, Revathy Senthilmohan, Roland Stocker, Joanne M. Upston, Roger T. Dean, Ryuichi Mashima, Andrew J. Brown, Xianwa Niu
Publikováno v:
The American Journal of Pathology. 160:701-710
Oxidative modification of low-density lipoprotein is thought to promote arterial lipid accumulation and atherogenesis. Previous studies reported on the presence of certain lipid or protein oxidation products in lesions, although a systematic investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4175d1a7954d7db2d0d33356ec671f
https://doi.org/10.1016/s0002-9440(10)64890-0
https://doi.org/10.1016/s0002-9440(10)64890-0
Publikováno v:
Biochemical Journal. 342:49-56
Ascorbate (AH, the reduced form of vitamin C) is an important radical scavenger and antioxidant in human plasma; the resulting ascorbyl radical can disproportionate to AH and dehydroascorbic acid (DHA). Here we address potential maintenance mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94976a652da8c0b74080b2bd44ba218a
https://doi.org/10.1042/bj3420049
https://doi.org/10.1042/bj3420049
Publikováno v:
The FASEB Journal. 13:977-994
The 'oxidation theory' of atherosclerosis proposes that oxidation of low density lipoprotein (LDL) contributes to atherogenesis. Although little direct evidence for a causative role of 'oxidized LDL' in atherogenesis exists, several studies show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a1471203b3ba0fce3db2873e38c0a4
https://doi.org/10.1096/fasebj.13.9.977
https://doi.org/10.1096/fasebj.13.9.977
Publikováno v:
Journal of Biological Chemistry. 272:30067-30074
15-Lipoxygenase has been implicated in the in vivo oxidation of low density lipoprotein (LDL) a process thought to be important in the origin and/or progression of human atherogenesis. We have suggested previously that oxidation of LDL's cholesteryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebe69cb00135381745916c2786771a9
https://doi.org/10.1074/jbc.272.48.30067
https://doi.org/10.1074/jbc.272.48.30067
Publikováno v:
Journal of Lipid Research, Vol 37, Iss 12, Pp 2650-2661 (1996)
Various lipoxygenases (LO) oxidize low density lipoprotein (LDL) in vitro and 15-LO has been implicated in the development of atherosclerosis in vivo. Direct oxidation of phospholipids (PL) and cholesteryl esters (CE) by LO has been proposed as a mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c63be788cacc9dd8ddd62c55c381e16
https://doi.org/10.1016/s0022-2275(20)37468-x
https://doi.org/10.1016/s0022-2275(20)37468-x
Autor:
Joanne M. Upston, Annette M. Gero
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1236:249-258
A mechanism which mediates the transport of the nonphysiological nucleoside, l -adenosine, was demonstrated in Plasmodium falciparum infected erythrocytes and naturally released merozoites. l -Adenosine was not a substrate for influx in freed intraer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d337d6f651129d6b57278e78e99006df
https://doi.org/10.1016/0005-2736(95)00055-8
https://doi.org/10.1016/0005-2736(95)00055-8
Publikováno v:
Progress in lipid research. 42(5)
Epidemiological and biochemical studies infer that oxidative processes, including the oxidation of low-density lipoprotein (LDL), are involved in atherosclerosis. Vitamin E has been the focus of several large supplemental studies of cardiovascular di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285fd94eba4a2adfe4350d4b242a1f24
https://pubmed.ncbi.nlm.nih.gov/12814643
https://pubmed.ncbi.nlm.nih.gov/12814643
Publikováno v:
Free radical biologymedicine. 31(10)
Oxidized low-density lipoproteins (LDL) are implicated in atherosclerosis. However, large-scale intervention studies designed to test whether antioxidants, such as vitamin E, can ameliorate cardiovascular disease have generated ambivalent results. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52855a8f7c93c05ad8650c55399d57b
https://pubmed.ncbi.nlm.nih.gov/11705703
https://pubmed.ncbi.nlm.nih.gov/11705703