Gut-on-a-Chip Research for Drug Development: Implications of Chip Design on Preclinical Oral Bioavailability or Intestinal Disease Studies

Autor: Joanne M. Donkers, Jamie I. van der Vaart, Evita van de Steeg

Publikováno v: Biomimetics, Vol 8, Iss 2, p 226 (2023)

The gut plays a key role in drug absorption and metabolism of orally ingested drugs. Additionally, the characterization of intestinal disease processes is increasingly gaining more attention, as gut health is an important contributor to our overall h

Externí odkaz: https://doaj.org/article/6ec2207fcad0449faf271b25f6e6e38f

Mechanistic insights into the inhibition of NTCP by myrcludex B

Autor: Joanne M. Donkers, Monique D. Appelman, Stan F.J. van de Graaf

Publikováno v: JHEP Reports, Vol 1, Iss 4, Pp 278-285 (2019)

Background & aims: The sodium taurocholate co-transporting polypeptide (NTCP) is the entry receptor for the hepatitis B and delta virus (HBV/HDV) and the main hepatic uptake transporter of conjugated bile acids. Myrcludex B, a synthetic peptide mimic

Externí odkaz: https://doaj.org/article/1dc24908cee141889011cda80393ed51

Inhibition of Hepatic Bile Acid Uptake by Myrcludex B Promotes Glucagon-Like Peptide-1 Release and Reduces ObesitySummary

Autor: Stan F.J. van de Graaf, Reinout L.P. Roscam Abbing, Joanne M. Donkers, Michel van Weeghel, Johannes H.M. Levels, Ronald P.J. Oude Elferink, Anita Boelen, Alfred H. Schinkel

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 451-466 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, 10(3), 451-466. Elsevier Inc.

Background & Aims Bile acids are important metabolic signaling molecules. Bile acid receptor activation promotes body weight loss and improves glycemic control. The incretin hormone GLP-1 and thyroid hormone activation of T4 to T3 have been suggested

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4c156a368ab5b8e88ab5658e7840fc
http://www.sciencedirect.com/science/article/pii/S2352345X20300539

Mechanistic insights into the inhibition of NTCP by myrcludex B

Autor: Monique D. Appelman, Joanne M. Donkers, Stan F.J. van de Graaf

Publikováno v: JHEP Reports
JHEP Reports, Vol 1, Iss 4, Pp 278-285 (2019)
JHEP Reports, 1(4), 278-285. Elsevier

Background & aims The sodium taurocholate co-transporting polypeptide (NTCP) is the entry receptor for the hepatitis B and delta virus (HBV/HDV) and the main hepatic uptake transporter of conjugated bile acids. Myrcludex B, a synthetic peptide mimick

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ecb8eab783e70f28fc4c3c75718e4f6
http://europepmc.org/articles/PMC7001544

Evaluation of Normothermic Machine Perfusion of Porcine Livers as a Novel Preclinical Model to Predict Biliary Clearance and Transporter-Mediated Drug-Drug Interactions Using Statins

Autor: P. P. Chothe, E. van de Steeg, Catherijne A. J. Knibbe, Ian P.J. Alwayn, Swapan Chowdhury, Andy Z. X. Zhu, L. J. Stevens, Joanne M. Donkers, Wouter H. J. Vaes

Publikováno v: Drug Metabolism and Disposition, 49(9), 780-789. AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS

There is a lack of translational preclinical models that can predict hepatic handling of drugs. In this study, we aimed to evaluate the applicability of normothermic machine perfusion (NMP) of porcine livers as a novel ex vivo model to predict hepati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e1d07819595c8930b13ced62ae3d42
https://pubmed.ncbi.nlm.nih.gov/34330719