Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Joanne M. Bowen"'
Autor:
Hannah R. Wardill, Ana Rita Da Silva Ferreira, Himanshu Kumar, Emma H. Bateman, Courtney B. Cross, Joanne M. Bowen, Rick Havinga, Hermie J. M. Harmsen, Jan Knol, Bram Dorresteijn, Miriam van Dijk, Jeroen van Bergenhenegouwen, Wim J. E. Tissing
Publikováno v:
Cell Death and Disease, Vol 14, Iss 5, Pp 1-11 (2023)
Abstract Cytotoxicity (i.e. cell death) is the core mechanism by which chemotherapy induces its anti-cancer effects. Unfortunately, this same mechanism underpins the collateral damage it causes to healthy tissues. The gastrointestinal tract is highly
Externí odkaz:
https://doaj.org/article/482db40cb7d744d09d27ea7752343e9d
Autor:
Anna Li, Joanne M. Bowen, Imogen A. Ball, Sophie Wilson, Angelina Yong, David T. Yeung, Cindy H. Lee, Robert V. Bryant, Samuel P. Costello, Feargal J. Ryan, Hannah R. Wardill
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3274 (2023)
Haematopoietic stem cell transplantation (HSCT) is a curative approach for blood cancers, yet its efficacy is undermined by a range of acute and chronic complications. In light of mounting evidence to suggest that these complications are linked to a
Externí odkaz:
https://doaj.org/article/cac9193e2d6149f1a3bfb6ffe4be830a
Publikováno v:
Cancers, Vol 15, Iss 17, p 4301 (2023)
Adverse effects are a common consequence of cytotoxic cancer treatments. Over the last two decades there have been significant advances in exploring the relationship between the gut microbiome and these adverse effects. Changes in the gut microbiome
Externí odkaz:
https://doaj.org/article/307dfc29863d410988d5c5053e50b7ae
Autor:
Elise E. Crame, Joanne M. Bowen, Kate R. Secombe, Janet K. Coller, Maxime François, Wayne Leifert, Hannah R. Wardill
Publikováno v:
Inflammatory Intestinal Diseases, Pp 1-11 (2021)
Introduction: Toll-like receptor 4 (TLR4) is a highly conserved immunosurveillance protein of innate immunity, displaying well-established roles in homeostasis and intestinal inflammation. Current evidence shows complex relationships between TLR4 act
Externí odkaz:
https://doaj.org/article/86b94b6a3d21484687c97bb9aae4b19d
Autor:
Kate R. Secombe, Imogen A. Ball, Anthony D. Wignall, Emma Bateman, Dorothy M. Keefe, Joanne M. Bowen
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 30, Iss , Pp 100806- (2022)
Background: Neratinib is a pan-ErbB tyrosine kinase inhibitor used for extended adjuvant treatment of HER2-positive breast cancer. Diarrhea is the main adverse event associated with neratinib treatment. We aimed here to determine whether antibiotic-i
Externí odkaz:
https://doaj.org/article/7e1901768b1942179f5a95af6966271e
Autor:
Ghanyah H. Al-Qadami, Kate R. Secombe, Courtney B. Subramaniam, Hannah R. Wardill, Joanne M. Bowen
Publikováno v:
Microorganisms, Vol 10, Iss 10, p 2048 (2022)
The gut microbiota has emerged as a key modulator of cancer treatment responses in terms of both efficacy and toxicity. This effect is clearly mediated by processes impacting the activation and modulation of immune responses. More recently, the abili
Externí odkaz:
https://doaj.org/article/15c28d0bde84402f87bda4550a52715a
Autor:
Kate R. Secombe, Ghanyah H. Al-Qadami, Courtney B. Subramaniam, Joanne M. Bowen, Jacqui Scott, Ysabella Z.A. Van Sebille, Matthew Snelson, Caitlin Cowan, Gerard Clarke, Cassandra E. Gheorghe, John F. Cryan, Hannah R. Wardill
Publikováno v:
Gut Microbes, Vol 13, Iss 1 (2021)
Fecal microbiota transplant (FMT) is a powerful tool used to connect changes in gut microbial composition with a variety of disease states and pathologies. While FMT enables potential causal relationships to be identified, the experimental details re
Externí odkaz:
https://doaj.org/article/19698be883f04b589aaa67518de4a882
Autor:
Kate R. Secombe BHSc (Hons), Ysabella Z. A. Van Sebille PhD, Bronwen J. Mayo PhD, Janet K. Coller PhD, Rachel J. Gibson PhD, Joanne M. Bowen PhD
Publikováno v:
Integrative Cancer Therapies, Vol 19 (2020)
Small molecule receptor tyrosine kinase inhibitors (SM-TKIs) are among a group of targeted cancer therapies, intended to be more specific to cancer cells compared with treatments, such as chemotherapy, hence reducing adverse events. Unfortunately, ma
Externí odkaz:
https://doaj.org/article/7ec33cd2800a42e8828cc2fbaafe97e5
Autor:
Joanne M. Bowen
Publikováno v:
Scientifica, Vol 2014 (2014)
Targeted therapy of cancer is often associated with clinically significant diarrhoea; however, the mechanisms underpinning this adverse effect are currently unknown. Diarrhoea following treatment with tyrosine kinase inhibitors (TKIs) of EGFR is part
Externí odkaz:
https://doaj.org/article/dc22c394f5a64f448decb55e2b4eada9
Autor:
Samantha K. Korver, Joanne M. Bowen, Rachel J. Gibson, Imogen A. Ball, Kate R. Secombe, Taylor J. Wain, Richard M. Logan, Jonathan Tuke, Kelly R. Mead, Alison M. Richards, Christos S. Karapetis, Dorothy M. Keefe, Janet K. Coller
Publikováno v:
Cancer Chemotherapy and Pharmacology. 91:507-521
Purpose Adverse effects following fluoropyrimidine-based chemotherapy regimens are common. However, there are no current accepted diagnostic markers for prediction prior to treatment, and the underlying mechanisms remain unclear. This study aimed to