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pro vyhledávání: '"Joanne M. Arrandale"'
Autor:
Jiang-Ming Ren, Ann C. Davis, Jian Zhu, Daniel U. Rabin, James N. Livingston, Ann R. Gore-Willse, Joanne M. Arrandale, Sandra Rocks
Publikováno v:
Journal of Biological Chemistry. 271:21353-21358
Syp is a protein tyrosine phosphatase implicated in insulin and growth factor signaling. To evaluate the role of syp in insulin's regulation of plasma glucose, we generated knockout mice. Homozygous knockout mice die prior to day 10.5 of embryonic de
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 11(10)
Human PRL binds Zn2+, but the function of the binding is not known. We investigated the effect on PRL production in pituitary cells by obtaining clones of GH4C1 cells stably transfected with human H27A-PRL, a mutant that does not bind Zn2+. Unexpecte
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 8(8)
GH4C1 cells increase storage of rat PRL and accumulation of dense core secretory granules when they are treated with 300 nM insulin, 1 nM estradiol, and 10 nM epidermal growth factor. In the experiments reported here, intracellular rat PRL increased