Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Joanne L Viney"'
Autor:
Alex Pellerin, Karel Otero, Julie M Czerkowicz, Hannah M Kerns, Renée I Shapiro, Ann M Ranger, Kevin L Otipoby, Frederick R Taylor, Thomas O Cameron, Joanne L Viney, Dania Rabah
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 4, Pp 464-476 (2015)
Abstract Type I interferons (IFN‐I) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). In SLE, immune complexes bind to the CD32a (FcγRIIa) receptor on the surface of plasmacytoid dendritic cells (pDCs) and stimulate the sec
Externí odkaz:
https://doaj.org/article/9ceab9bde5004b959003e383c7a33823
Autor:
Agnes Gardet, Wei C Chou, Taylor L Reynolds, Diana B Velez, Kai Fu, Julia M Czerkowicz, Jeffrey Bajko, Ann M Ranger, Normand Allaire, Hannah M Kerns, Sarah Ryan, Holly M Legault, Robert W Dunstan, Robert Lafyatis, Matvey Lukashev, Joanne L Viney, Jeffrey L Browning, Dania Rabah
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164423 (2016)
Mouse models lupus nephritis (LN) have provided important insights into disease pathogenesis, although none have been able to recapitulate all features of the human disease. Using comprehensive longitudinal analyses, we characterized a novel accelera
Externí odkaz:
https://doaj.org/article/de2edfb8f586497f81cac95be2baa6e6
Publikováno v:
Frontiers in Pharmacology, Vol 4 (2013)
Genetic studies of human diseases have identified multiple genetic risk loci for various fibrotic diseases. This has provided insights into the myriad of biological pathways potentially involved in disease pathogenesis. These discoveries suggest that
Externí odkaz:
https://doaj.org/article/1dfd4519c022478b94e3b3e70da8965d
Autor:
Purvi Mande, Susmita Borthakur, Daniel Rios, Patrick Halvey, Angela Boisvert, Michael Rowe, Anisha Agrawal, Mike Cianci, Minasri Borah, Joanne L Viney, Katalin Kis-Toh, Nathan Higginson-Scott, Kevin L Otipoby, Ivan Mascanfroni
Publikováno v:
The Journal of Immunology. 206:66.11-66.11
Current treatment approaches for autoimmune conditions comprise primarily of systemic immunosuppressants or cytokine blockade. Concentration of therapeutic molecules to the tissues that are the sites of autoimmune and inflammatory diseases is a promi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b12f690138ce47a0a4f6aef2876fa6ce
https://doi.org/10.4049/jimmunol.206.supp.66.11
https://doi.org/10.4049/jimmunol.206.supp.66.11
Autor:
Jiwon Jung, Bridget M Larkin, Gaurav Rajani, Minasri Borah, Celesztina Nagy-Domonkos, Weijie Zhou, Kevin L Otipoby, Joanne L Viney, Nathan Higginson-Scott, Ivan Mascanfroni, Hussam H Shaheen
Publikováno v:
The Journal of Immunology. 206:18.04-18.04
The complement system plays a major role in humoral innate immunity. Upon activation, complement proteins trigger a cascade of enzymatic events leading to the production of inflammatory mediators and membrane attack complexes. Tight regulation of com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e49ea8deec76487674539009a2dbbfa8
https://doi.org/10.4049/jimmunol.206.supp.18.04
https://doi.org/10.4049/jimmunol.206.supp.18.04
Autor:
Bridget M Larkin, Jyothsna Visweswaraiah, Bilian Li, Komal Pradhan, Michael Rowe, Gaurav Rajani, Celesztina Nagy-Domonkos, Nathan Higginson-Scott, Joanne L Viney, Kevin L Otipoby, Hussam H Shaheen, Ivan Mascanfroni
Publikováno v:
The Journal of Immunology. 206:28.20-28.20
Regulatory T cells (Treg) play a critical role in maintaining graft tolerance following organ transplantation, and increased numbers of Tregs in solid-tissue grafts such as the kidney are associated with improved graft survival and function. Therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e3de40a01ab7f5d2eedf66a12743a1b
https://doi.org/10.4049/jimmunol.206.supp.28.20
https://doi.org/10.4049/jimmunol.206.supp.28.20
Autor:
Jyothsna Visweswaraiah, Erik R Sampson, Timothy Kiprono, Parika Petaipimol, Adrianne Monsef, Katalin Kis-Toth, Kevin L Otipoby, John Sundy, Nathan Higginson-Scott, Joanne L Viney
Publikováno v:
The Journal of Immunology. 206:66.14-66.14
Regulatory T cells (Treg) are vital for immune homeostasis and are dysfunctional in autoimmunity. Interleukin 2 (IL-2) drives the proliferation and function of Tregs via its heterotrimeric receptor (CD25/CD122/CD132). Low dose IL-2 is being evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65768ddf9e253248a7bec80943d34b0c
https://doi.org/10.4049/jimmunol.206.supp.66.14
https://doi.org/10.4049/jimmunol.206.supp.66.14
Autor:
Jeroen DeGroot, Britt Sotthewes, Jeska K de Vries-Bouwstra, Kejie Li, Patrick Cullen, Joanne L. Viney, Agnes Gardet, Jamil Aarbiou, Marc Cheung, S.N. Andersen, Tom W J Huizinga, Timothy S. Zheng, Ellen Cahir-McFarland, David F. Fischer, Annemarie L. Dorjée, Loubna Chadli
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, 9
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, 9
Systemic sclerosis (SSc or scleroderma) is an auto-immune disease characterized by skin fibrosis. While primary cells from patients are considered as a unique resource to better understand human disease biology, the effect of in vitro culture on thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bf5aa74571f4c6006cf556a8921991
https://pubmed.ncbi.nlm.nih.gov/30872777
https://pubmed.ncbi.nlm.nih.gov/30872777
Autor:
Dania Rabah, Thomas Cameron, Alex Pellerin, Hannah M. Kerns, Frederick R. Taylor, Kevin L. Otipoby, Julie Czerkowicz, Renee I. Shapiro, Karel Otero, Ann Ranger, Joanne L. Viney
Publikováno v:
EMBO Molecular Medicine
Type I interferons (IFN-I) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). In SLE, immune complexes bind to the CD32a (FcγRIIa) receptor on the surface of plasmacytoid dendritic cells (pDCs) and stimulate the secretion of I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6bf43a25332ae182f915a160b4209e
http://europepmc.org/articles/PMC4403047
http://europepmc.org/articles/PMC4403047
Autor:
Joanne L. Viney, Janine Bilsborough
Publikováno v:
Nature immunology
Lymphocyte recruitment maintains intestinal immune homeostasis but also contributes to inflammation. The orphan chemoattractant receptor GPR15 mediates regulatory T cell homing and immunosuppression in the mouse colon. We show that GPR15 is also expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0daa528b0f332d4d5ac9f47814283eb
https://doi.org/10.1038/ni.3084
https://doi.org/10.1038/ni.3084