Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Joanne L Attema"'
Autor:
Joanne L Attema, Andrew G Bert, Yat-Yuen Lim, Natasha Kolesnikoff, David M Lawrence, Katherine A Pillman, Eric Smith, Paul A Drew, Yeesim Khew-Goodall, Frances Shannon, Gregory J Goodall
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75517 (2013)
The miR-200b~200a~429 gene cluster is a key regulator of EMT and cancer metastasis, however the transcription-based mechanisms controlling its expression during this process are not well understood. We have analyzed the miR-200b~200a~429 locus for ep
Externí odkaz:
https://doaj.org/article/a59b1b8a8d0d4780929167d1d70fe099
Autor:
Wen Juan Tu, Philip A. Gregory, Jane E. Dahlstrom, Abel Tan, Sudha Rao, Anjum Zafar, Gregory J. Goodall, Janelle L. Harris, Peter J. Milburn, Tara Boulding, Kirsti Harrington, Kristine Hardy, Joanne L. Attema, Robert McCuaig, Fan Wu, Rebecca Madden, Jasmine Li, Kum Kum Khanna
Publikováno v:
Molecular and Cellular Biology. 34:2961-2980
Epithelial to mesenchymal transition (EMT) is activated during cancer invasion and metastasis, enriches for cancer stem cells (CSCs), and contributes to therapeutic resistance and disease recurrence. Signal transduction kinases play a pivotal role as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210eeec57f88c02d55c2d830a6254ce0
https://doi.org/10.1128/mcb.01693-13
https://doi.org/10.1128/mcb.01693-13
Autor:
Natasha Kolesnikoff, Quenten Schwarz, Joanne L. Attema, Andrew G. Bert, Gregory J. Goodall, Suraya Roslan, Philip A. Gregory
Publikováno v:
Journal of Biological Chemistry. 289:11194-11205
Epithelial-mesenchymal transition (EMT) is required for the specification of tissues during embryonic development and is recapitulated during the metastatic progression of tumors. The miR-200 family plays a critical role in enforcing the epithelial s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0d2ee5701aa54fb26bc0cefb70b825c
https://doi.org/10.1074/jbc.m113.529172
https://doi.org/10.1074/jbc.m113.529172
Autor:
Nils Wierup, Emma Nilsson, Ola Hansson, Peter Almgren, Stefan Lang, Ylva Wessman, Elin Hall, Targ Elgzyri, Beatrice T. Yang, Holger Weishaupt, Leif Groop, Peter Volkov, Hemang Parikh, Marloes Dekker Nitert, Mia Abels, Tina Rönn, Tasnim Dayeh, Karl-Frederik Eriksson, Charlotte Ling, Joanne L. Attema, Per-Anders Jansson
Publikováno v:
Diabetes
To identify epigenetic patterns, which may predispose to type 2 diabetes (T2D) due to a family history (FH) of the disease, we analyzed DNA methylation genome-wide in skeletal muscle from individuals with (FH+) or without (FH−) an FH of T2D. We fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65757840b50ac61baea395d12abffcc
http://europepmc.org/articles/PMC3501844
http://europepmc.org/articles/PMC3501844
Publikováno v:
Blood. 115:247-256
Heritable epigenetic signatures are proposed to serve as an important regulatory mechanism in lineage fate determination. To investigate this, we profiled chromatin modifications in murine hematopoietic stem cells, lineage-restricted progenitors, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67fad54c089bb342409a352d9ba060c1
https://doi.org/10.1182/blood-2009-07-235176
https://doi.org/10.1182/blood-2009-07-235176
Autor:
Naoki Hosen, Peter Papathanasiou, Joanne L. Attema, Robert Tunningley, Stephen T. Smale, Yovina Sontani, Irving L. Weissman, Holger Karsunky, Gerard F. Hoyne
Publikováno v:
Stem Cells. 27:3082-3092
Hematopoietic stem cells (HSCs) are rare, ancestral cells that underlie the development, homeostasis, aging, and regeneration of the blood. Here we show that the chromatin-associated protein Ikaros is a crucial self-renewal regulator of the long-term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb7891226174466f8d09a21fe607a03
https://doi.org/10.1002/stem.232
https://doi.org/10.1002/stem.232
Autor:
Holger Karsunky, Peter Papathanasiou, Irving L. Weissman, Jian Xu, Joanne L. Attema, Stephen T. Smale
Publikováno v:
Stem Cells. 27:2498-2508
Blood is a tissue with a high cell turnover rate that is constantly being replenished by bone marrow hematopoietic stem cells (HSCs) seeded during fetal ontogeny from the liver. Here we show that the long-term (LT) reconstituting subset of cKit+Thy1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ca7bc5d7006c3d5b3cfcb27113b946
https://doi.org/10.1002/stem.170
https://doi.org/10.1002/stem.170
Autor:
David Bryder, Robert Månsson, Joanne L. Attema, Derrick J. Rossi, Mikael Sigvardsson, Irving L. Weissman, Gudmundur L. Norddahl, Charles Chan, Cornelis J.H. Pronk
Publikováno v:
Cell Stem Cell. 1:428-442
SummaryThe major myeloid blood cell lineages are generated from hematopoietic stem cells by differentiation through a series of increasingly committed progenitor cells. Precise characterization of intermediate progenitors is important for understandi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b63cb36d579a3cf5b094da145409e3
https://doi.org/10.1016/j.stem.2007.07.005
https://doi.org/10.1016/j.stem.2007.07.005
Autor:
Kenneth S. Zaret, Scott D. Pope, Joanne L. Attema, Jian Xu, Irving L. Weissman, Stephen T. Smale, Peter Papathanasiou, Jason A. Watts, Ali R. Jazirehi
Publikováno v:
Proceedings of the National Academy of Sciences. 104:12377-12382
Recent studies have suggested that, in ES cells, inactive genes encoding early developmental regulators possess bivalent histone modification domains and are therefore poised for activation. However, bivalent domains were not observed at typical tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee400024e637b4dc2132615c834dd8c0
https://doi.org/10.1073/pnas.0704579104
https://doi.org/10.1073/pnas.0704579104
Autor:
E. Camilla Forsberg, Joanne L. Attema, Peter Papathanasiou, Jian Xu, Stephen T. Smale, Irving L. Weissman
Publikováno v:
Proceedings of the National Academy of Sciences. 104:12371-12376
Hematopoietic stem cells (HSC) produce all blood cell lineages by virtue of their capacity to self-renew and differentiate into progenitors with decreasing cellular potential. Recent studies suggest that epigenetic mechanisms play an important role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9d270e2a81d48c288258bdc9f953fb
https://doi.org/10.1073/pnas.0704468104
https://doi.org/10.1073/pnas.0704468104