Zobrazeno 1 - 10
of 266
pro vyhledávání: '"Joanne L, Flynn"'
Autor:
Carly A. Bobak, Keisean A. J. M. Stevenson, Ning Sun, Mohammad S. Khan, Jannatul Azmir, Marco Beccaria, Jaime A. Tomko, Daniel Fillmore, Charles A. Scanga, Philana L. Lin, JoAnne L. Flynn, Jane E. Hill
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Non-human primates remain the most useful and reliable pre-clinical model for many human diseases. Primate breath profiles have previously distinguished healthy animals from diseased, including non-human primates. Breath collection is relati
Externí odkaz:
https://doaj.org/article/adc469523e3c44eb973673d39536127e
Autor:
Edward B. Irvine, Patricia A. Darrah, Shu Wang, Chuangqi Wang, Ryan P. McNamara, Mario Roederer, Robert A. Seder, Douglas A. Lauffenburger, JoAnne L. Flynn, Sarah M. Fortune, Galit Alter
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111128- (2024)
Summary: Altering Bacille Calmette-Guérin (BCG) immunization from low-dose intradermal (i.d.) to high-dose intravenous (i.v.) vaccination provides a high level of protection against Mycobacterium tuberculosis (Mtb). In addition to strong T cell immu
Externí odkaz:
https://doaj.org/article/3a7ffcc85dc94f49b647fd43b83a2e7f
Autor:
R. M. Naseer Khan, Yong-Mo Ahn, Gwendolyn A. Marriner, Laura E. Via, Francois D’Hooge, Seung Seo Lee, Nan Yang, Falguni Basuli, Alexander G. White, Jaime A. Tomko, L. James Frye, Charles A. Scanga, Danielle M. Weiner, Michelle L. Sutphen, Daniel M. Schimel, Emmanuel Dayao, Michaela K. Piazza, Felipe Gomez, William Dieckmann, Peter Herscovitch, N. Scott Mason, Rolf Swenson, Dale O. Kiesewetter, Keriann M. Backus, Yiqun Geng, Ritu Raj, Daniel C. Anthony, JoAnne L. Flynn, Clifton E. Barry, Benjamin G. Davis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Tuberculosis remains a large global disease burden for which treatment regimens are protracted and monitoring of disease activity difficult. Existing detection methods rely almost exclusively on bacterial culture from sputum which limits sam
Externí odkaz:
https://doaj.org/article/78179b9a20084b6790bf89a43f40ffbf
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Some persistent infections provide a level of immunity that protects against reinfection with the same pathogen, a process referred to as concomitant immunity. To explore the phenomenon of concomitant immunity during Mycobacterium tuberculos
Externí odkaz:
https://doaj.org/article/2142c077147c49f5b7fe08c4bb5950db
Autor:
Swati Jaiswal, Sarah K. Nyquist, Shayla Boyce, Tasneem Jivanjee, Samira Ibrahim, Joshua D. Bromley, G. James Gatter, Hannah Gideon, Kush Patel, Sharie Keanne Ganchua, Bonnie Berger, Sarah M. Fortune, JoAnne L. Flynn, Alex K. Shalek, Samuel M. Behar
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Cynomolgus macaque (Macaca fascicularis) is an attractive animal model for the study of human disease and is extensively used in biomedical research. Cynomolgus macaques share behavioral, physiological, and genomic traits with hum
Externí odkaz:
https://doaj.org/article/0fcfddea48094cb580d2427baab18647
Publikováno v:
Insights into Imaging, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Close contacts of individuals with pulmonary tuberculosis are at risk for tuberculosis infection and the development of active tuberculosis. In current contact investigations, immunologic tests (the tuberculin skin test and interferon-gamma
Externí odkaz:
https://doaj.org/article/a952a124d547431b9cf74271ffdecf51
Autor:
Maral Budak, Joseph M Cicchese, Pauline Maiello, H Jacob Borish, Alexander G White, Harris B Chishti, Jaime Tomko, L James Frye, Daniel Fillmore, Kara Kracinovsky, Jennifer Sakal, Charles A Scanga, Philana Ling Lin, Véronique Dartois, Jennifer J Linderman, JoAnne L Flynn, Denise E Kirschner
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 6, p e1010823 (2023)
Tuberculosis (TB) continues to be one of the deadliest infectious diseases in the world, causing ~1.5 million deaths every year. The World Health Organization initiated an End TB Strategy that aims to reduce TB-related deaths in 2035 by 95%. Recent r
Externí odkaz:
https://doaj.org/article/6c3730d6ea76411e8f9be1bff53e7a93
Autor:
Nicole L. Grant, Kristen Kelly, Pauline Maiello, Helena Abbott, Shelby O’Connor, Philana Ling Lin, Charles A. Scanga, JoAnne L. Flynn
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Despite the extensive research on CD4 T cells within the context of Mycobacterium tuberculosis (Mtb) infections, few studies have focused on identifying and investigating the profile of Mtb-specific T cells within lung granulomas. To facilit
Externí odkaz:
https://doaj.org/article/0bd7932b650b4c48833d648c0ad5e9a1
Autor:
Nicole L. Grant, Pauline Maiello, Edwin Klein, Philana Ling Lin, H. Jacob Borish, Jaime Tomko, L. James Frye, Alexander G. White, Denise E. Kirschner, Joshua T. Mattila, JoAnne L. Flynn
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110826- (2022)
Summary: Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a global health concern, yearly resulting in 10 million new cases of active TB. Immunologic investigation of lung granulomas is essential for understanding host c
Externí odkaz:
https://doaj.org/article/27d79ee8867c4472a720d0e7466b5302
Autor:
Jess A. Millar, J. Russell Butler, Stephanie Evans, Nicole L. Grant, Joshua T. Mattila, Jennifer J. Linderman, JoAnne L. Flynn, Denise E. Kirschner
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/bf3567b2577c4e5a9d254f761658596f