Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Joanne Kotz"'
Autor:
Joshua M. Francis, Stuart L. Schreiber, Mathias Wawer, Patricia Cogswell, Francisca Vazquez, Nathanael S. Gray, James E. Bradner, Joanne Kotz, Ting Chen, Julian Blagg, Slim Sassi, Glenn S. Cowley, Matthew A. Lawlor, Tanaz Sharifnia, Paul A. Clemons, David E. Root, Paul A. Clarke, Ann E. Sizemore, William C. Hahn, Charles Y. Lin, Josh Sommer, Paul Workman, Amy Goodale, Francis J. Hornicek, Qingyuan Huang, Kwok K. Wong, Barbara A. Weir, Hadley E. Sheppard, Tinghu Zhang, Christopher J. Ott
Publikováno v:
Nature medicine
Chordoma is a primary bone cancer with no approved therapy1. The identification of therapeutic targets in this disease has been challenging due to the infrequent occurrence of clinically actionable somatic mutations in chordoma tumors2,3. Here we des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f3b0242e05910ecb690ec2943d646f
https://doi.org/10.1038/s41591-018-0312-3
https://doi.org/10.1038/s41591-018-0312-3
Autor:
Min Li, Hugh Rosen, Donghoon Chung, Owen B. McManus, Shaun R. Stauffer, Thomas D.Y. Chung, P. Jeffrey Conn, Stuart L. Schreiber, Michael R. Jackson, Jennifer E. Golden, Andrea de Souza, Edward Roberts, Joanne Kotz, Christopher P. Austin, William Severson, Patrick R. Griffin, Subramaniam Ananthan, Mathias J. Wawer, Alykhan F. Shamji, Tudor I. Oprea, Ajit Jadhav, Frank J. Schoenen, Michael R. Wood, Anton Simeonov, Michael Foley, Haibo Yu, Peter Hodder, Jeffrey Aubé, William R. Roush, Benjamin Alexander, E. Lucile White, Benjamin F. Cravatt, Joshua A. Bittker, James W. Noah, Beiyan Zou, Kyle A. Emmitte, Meng Wu, John C. Reed, Corey R. Hopkins, Colleen B. Jonsson, Anthony B. Pinkerton, Larry A. Sklar, Michelle Palmer, Craig W. Lindsley, Paul A. Clemons, Bruce S. Edwards
Publikováno v:
Cell. 161:1252-1265
Small-molecule probes can illuminate biological processes and aid in the assessment of emerging therapeutic targets by perturbing biological systems in a manner distinct from other experimental approaches. Despite the tremendous promise of chemical t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c63d6674264edc9195e8979c881450
https://doi.org/10.1016/j.cell.2015.05.023
https://doi.org/10.1016/j.cell.2015.05.023
Autor:
Cindy S. Hon, Brian M. Wolpin, Ossia M. Eichhoff, Pablo Tamayo, James M. Cleary, Shrikanta Chattopadhyay, Matthew G. Rees, Elisabeth Roider, Brent R. Stockwell, Xiaoyun Wu, Vasanthi S. Viswanathan, Alykhan F. Shamji, Kenichi Shimada, Cherrie Huang, Joanne Kotz, Michael E. Berens, Brinton Seashore-Ludlow, Jesse S. Boehm, Dong Gao, Daniel A. Haber, John G. Doench, Yu Chen, William C. Hahn, Andrew J. Aguirre, Harshil Dhruv, John K. Eaton, Sixun Chen, Samuel D. Kaffenberger, Matthew J. Ryan, Zarko V. Boskovic, Sarah Javaid, Yuen-Yi Tseng, Wan Seok Yang, Jeffrey A. Engelman, Jill P. Mesirov, Shubhroz Gill, Paul A. Clemons, Stuart L. Schreiber, Srinivas R. Viswanathan, Mitchell P. Levesque
Publikováno v:
Nature, vol 547, iss 7664
Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer therapies, thereby limiting their effectiveness. A high-mesenchymal cell state observed in human tumours and cancer cell lines has been associated with r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ba838eb1e39116320b2c600fbd386f
https://escholarship.org/uc/item/9t553104
https://escholarship.org/uc/item/9t553104
Autor:
Daniel A. Haber, Bridget K. Wagner, Philip Montgomery, Benito Munoz, Matthew G. Rees, Jaime H. Cheah, Alykhan F. Shamji, C. Suk-Yee Hon, Stuart L. Schreiber, Drew J. Adams, Vlado Dančík, Joanne Kotz, Clary B. Clish, Brinton Seashore-Ludlow, Joshua A. Bittker, Edmund Price, Nicole E. Bodycombe, Benjamin Alexander, Michelle Palmer, Sarah Javaid, Matthew E. Coletti, Paul A. Clemons, Christian K Soule, Ava Li, Shubhroz Gill, Ted Liefeld, Victor Victor Jones
Publikováno v:
Nature chemical biology
Changes in cellular gene expression in response to small-molecule or genetic perturbations have yielded signatures that can connect unknown mechanisms of action (MoA) to ones previously established. We hypothesized that differential basal gene expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad324836b82c33e256be84df46a99575
https://pubmed.ncbi.nlm.nih.gov/28966993
https://pubmed.ncbi.nlm.nih.gov/28966993
Autor:
Joanne Kotz, Michelle Palmer, James E. Bradner, Alykhan F. Shamji, C. Suk-Yee Hon, Vlado Dančík, Joshua A. Bittker, Mathias Wawer, Stuart L. Schreiber, Jaime H. Cheah, Matthew G. Rees, Brinton Seashore-Ludlow, Nurdan Kuru, Christian K. Soule, Murat Cokol, Ava Li, Edmund Price, Matthew E. Coletti, Victor Victor Jones, Benjamin Alexander, Philip Montgomery, Benito Munoz, Nicole E. Bodycombe, Ted Liefeld, Paul A. Clemons, Joshua Gould
Publikováno v:
Cancer discovery. 5(11)
Identifying genetic alterations that prime a cancer cell to respond to a particular therapeutic agent can facilitate the development of precision cancer medicines. Cancer cell-line (CCL) profiling of small-molecule sensitivity has emerged as an unbia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd399cb3a6685d80217b251f5edb61d
https://pubmed.ncbi.nlm.nih.gov/26482930
https://pubmed.ncbi.nlm.nih.gov/26482930
Autor:
Kerry A. Pierce, Mathias Wawer, Joanne Kotz, Francois Mercier, David T. Scadden, Stuart L. Schreiber, Steven James Ferrara, Hanna Meyer, Detlef Stoeckigt, Ashley Eheim, Paul A. Clemons, Anna Waller, Jason M. Law, David B. Sykes, Timothy A. Lewis, Andreas Janzer, Ruslan I. Sadreyev, Katrina Maxcy, Jacqueline Bachand, Brian A. Szekely, Amir Schajnovitz, Larry A. Sklar, Julien Cobert, Clary B. Clish, Esha Jain, Nicola Tolliday, Siddhartha Mukherjee, Youmna Kfoury, Mark K. Haynes, Dongjun Lee
Publikováno v:
Cell. 167:171-186.e15
While acute myeloid leukemia (AML) comprises many disparate genetic subtypes, one shared hallmark is the arrest of leukemic myeloblasts at an immature and self-renewing stage of development. Therapies that overcome differentiation arrest represent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6d48ff1999e6d6d760e7fa5d81bb56e
https://doi.org/10.1016/j.cell.2016.08.057
https://doi.org/10.1016/j.cell.2016.08.057
Autor:
Joanne Kotz
Publikováno v:
Nature chemical biology. 4(8)
A new web portal helps connect scientists and coordinate scientific efforts to address the challenges of the developing world.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e430bc57cc2f166e9fd65c63748f3416
https://pubmed.ncbi.nlm.nih.gov/18641619
https://pubmed.ncbi.nlm.nih.gov/18641619
Autor:
Joanne Kotz
Publikováno v:
Nature chemical biology. 4(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ed4360703492443b6be570e84c0556
https://pubmed.ncbi.nlm.nih.gov/18277971
https://pubmed.ncbi.nlm.nih.gov/18277971
Autor:
Joanne Kotz
Publikováno v:
Nature chemical biology. 3(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee9eda60e761919c44c7049380477e4
https://pubmed.ncbi.nlm.nih.gov/17235339
https://pubmed.ncbi.nlm.nih.gov/17235339
Autor:
Mathias Frederiksen, Paul Brennan, Christopher M. Austin, Robert M. Campbell, Kilian Huber, Robert A. Copeland, Bryan L. Roth, Cheryl H. Arrowsmith, Joanne Kotz, Julian Blagg, Stefan Knapp, Brian D. Marsden, Matthieu Schapira, Adrian Carter, Trevor Howe, Carolyn Buser-Doepner, Anke Mueller-Fahrnow, Ronan C. O'Hagan, Ben Cravatt, Paul Workman, John P. Overington, C. Bountra, Dafydd R. Owen, Stephen V. Frye, Michael A. Walters, Jayme L. Dahlin, Susanne Müller, Charles E. Grimshaw, Nathanael S. Gray, Stuart L. Schreiber, Derek B. Lowe, Saul H Rosenberg, Leticia Toledo-Sherman, Mark E. Bunnage, Brian K. Shoichet, Peter Brown, Philip Cohen, Giulio Superti-Furga, Aled M. Edwards, Michael Sundström, Jonathan B. Baell, Jack Taunton, Chris Walpole, Mary M. Mader, Jian Jin, William J. Zuercher, David Hepworth, Timothy M. Willson, Ryan G. Kruger, Dashyant Dhanak, James E. Audia, Ruth A. Ross, Robert N. Young, Jonathan Bennett
Publikováno v:
Nature Chemical Biology. 11:887-887
Nat. Chem. Biol. 11, 536–541 (2015); published online 21 July 2015; corrected after print 16 September 2015. In the version of this Commentary initially published, there were several errors in the author list and author affiliations. Bryan Roth was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fe2c1963925723b1521d59fc27619b0
https://doi.org/10.1038/nchembio1115-887c
https://doi.org/10.1038/nchembio1115-887c