Zobrazeno 1 - 10 of 52 pro vyhledávání: '"Joanne I. Yeh"'
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Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment
Autor: Sreya Tarafdar, John Jeff Alvarado, Joanne I. Yeh, Thomas E. Smithgall
Publikováno v: Journal of Biological Chemistry. 289:28539-28553
HIV-1 Nef supports high titer viral replication in vivo and is essential for AIDS progression. Nef function depends on interactions with multiple host cell effectors, including Hck and other Src-family kinases. Here we describe the x-ray crystal stru
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4361b03df46ccbff1fe826b5138935
https://doi.org/10.1074/jbc.m114.600031
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10
Effector Kinase Coupling Enables High-Throughput Screens for Direct HIV-1 Nef Antagonists with Antiretroviral Activity
Autor: Haibin Shi, Purushottam Narute, Joanne I. Yeh, Paul A. Johnston, Naveena Yanamala, Lori A. Emert-Sedlak, Sherry T. Shu, Thomas E. Smithgall, Jerrod A. Poe, John Jeff Alvarado, John S. Lazo
Publikováno v: Chemistry & Biology. 20:82-91
SummaryHIV-1 Nef, a critical AIDS progression factor, represents an important target protein for antiretroviral drug discovery. Because Nef lacks intrinsic enzymatic activity, we developed an assay that couples Nef to the activation of Hck, a Src fam
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f94dd5481c8874100b7f7e07047b69b
https://doi.org/10.1016/j.chembiol.2012.11.005
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