Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Joanne Hsieh"'
Autor:
Kristin M. McCabe, Joanne Hsieh, David G. Thomas, Matthew M. Molusky, Liana Tascau, Jun B. Feranil, Li Qiang, Anthony W. Ferrante, Jr., Alan R. Tall
Publikováno v:
Molecular Metabolism, Vol 34, Iss , Pp 146-156 (2020)
Objective: In mouse models, deficiency of TTC39B (T39) decreases hepatic lipogenic gene expression and protects against diet-induced steatohepatitis. While assessing the therapeutic potential of antisense oligonucleotides (ASOs) targeting T39, we dis
Externí odkaz:
https://doaj.org/article/04e06894453b43d483a10eb29623aa72
Autor:
Liana Tascau, Joanne Hsieh, Tong Xiao, Alan R. Tall, Matthew M. Molusky, Lars Zeana-Schliep, Panagiotis Fotakis, Paul DaSilva-Jardine, Kristin M. McCabe
Publikováno v:
J Hepatol
Background/Aims Molecular mechanisms underlying the different susceptibility of men and women to NAFLD are poorly understood. The TTC39B locus encodes a scaffolding protein, associates with gynecological disorders and its deletion protects mice from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5be3f8afcd8ed7a16596e488d61d0c
https://doi.org/10.1016/j.jhep.2021.09.021
https://doi.org/10.1016/j.jhep.2021.09.021
Autor:
Anthony W. Ferrante, Matthew M. Molusky, David G. Thomas, Liana Tascau, Kristin M. McCabe, Alan R. Tall, Li Qiang, Joanne Hsieh, Jun B. Feranil
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 34, Iss, Pp 146-156 (2020)
Molecular Metabolism, Vol 34, Iss, Pp 146-156 (2020)
Objective In mouse models, deficiency of TTC39B (T39) decreases hepatic lipogenic gene expression and protects against diet-induced steatohepatitis. While assessing the therapeutic potential of antisense oligonucleotides (ASOs) targeting T39, we disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9033910c2145afa4d053540659ac5a00
https://doi.org/10.1016/j.molmet.2020.01.010
https://doi.org/10.1016/j.molmet.2020.01.010
Autor:
Joanne Hsieh, Ze Zheng, Lale Ozcan, Gabrielle Fredman, Judith C. Sluimer, Ira Tabas, Christina C. Rymond, Alan R. Tall, Bernhard Dorweiler, Amanda C. Doran, George Kuriakose, Bishuang Cai
Publikováno v:
Journal of Clinical Investigation, 127(11), 4075-4089. American Society for Clinical Investigation
Atherosclerosis is the underlying etiology of cardiovascular disease, the leading cause of death worldwide. Atherosclerosis is a heterogeneous disease in which only a small fraction of lesions lead to heart attack, stroke, or sudden cardiac death. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84abcb7a43e4b9faa481c0cc597e34e8
https://cris.maastrichtuniversity.nl/en/publications/c99397ac-7e8e-4551-8b4e-ed5f66c1a991
https://cris.maastrichtuniversity.nl/en/publications/c99397ac-7e8e-4551-8b4e-ed5f66c1a991
Autor:
Xu Shi, Robert E. Gerszten, Maria Hamm de Miguel, Olle Melander, Alan R. Tall, Joanne Hsieh, Renu Regunathan-Shenk, Yuan Zhang, Jonathan Hogan, Annie J. Febus, Eric Lai, Jessica R. Singer, Rafael Lantigua, Martin Magnusson, Nan Wang, Anjali Ganda, Andrew J. Murphy, Nora Bijl, Serge Cremers, Farah N. Hussain, Ying Wang, Linda Vernocchi, Rupali S. Avasare, Bibhas Chakraborty, Laurent Yvan-Charvet, Kristie M. Gordon
Publikováno v:
Journal of Molecular and Cellular Cardiology. 112:114-122
Patients with chronic kidney disease (CKD) experience high rates of atherosclerotic cardiovascular disease and death that are not fully explained by traditional risk factors. In animal studies, defective cellular cholesterol efflux pathways which are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3f2919a36e128966c910b5e42fe2f0
https://doi.org/10.1016/j.yjmcc.2017.05.001
https://doi.org/10.1016/j.yjmcc.2017.05.001
Autor:
Shizuya Yamashita, M. Mahmood Hussain, Daniel J. Rader, Jahangir Iqbal, Marit Westerterp, Masahiro Koseki, Jay H. Lefkowitch, Alan R. Tall, Joanne Hsieh, Ikuyo Ichi, Robin B. Chan, Liana Tascau, Matthew M. Molusky, Carrie L. Welch, Sandra Abramowicz, Shunichi Takiguchi, Emi Yakushiji, Gilbert Di Paolo
Publikováno v:
Nature
Nature, 535:7611, 303-307. Nature Publishing Group
Nature, 535:7611, 303-307. Nature Publishing Group
Cellular mechanisms that mediate steatohepatitis, an increasingly prevalent condition in the Western world for which no therapies are available, are poorly understood. Despite the fact that its synthetic agonists induce fatty liver, the liver X recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09979db7c9fd77e84dfeb0184b7bfcaf
https://doi.org/10.1038/nature18628
https://doi.org/10.1038/nature18628
Autor:
Khosrow Adeli, Mahmood Hussain, Joanne Hsieh, Elizabeth J. Lake, Christopher Baker, Jahangir Iqbal, Sarah Farr, Karin Trajcevski, Jennifer Taher
Publikováno v:
Endocrinology. 156:3538-3547
The intestinal overproduction of apolipoprotein B48 (apoB48)-containing chylomicron particles is a common feature of diabetic dyslipidemia and contributes to cardiovascular risk in insulin resistant states. We previously reported that glucagon-like p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffaedd9e23b32f0198f43f4336526d28
https://doi.org/10.1210/en.2015-1110
https://doi.org/10.1210/en.2015-1110
Autor:
Andrew J. Brown, Joanne Hsieh
Publikováno v:
Circulation Research. 118:371-373
Forty years ago, Akira Endo discovered that a fungal metabolite inhibits 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the rate limiting step of the mevalonate pathway and therefore cholesterol biosynthesis, and initiated the development o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf00086aaa15f03802cb37d4a65680eb
https://doi.org/10.1161/circresaha.116.308191
https://doi.org/10.1161/circresaha.116.308191
Publikováno v:
Diabetes. 62:373-381
The glucagon-like peptides (GLP-1 and GLP-2) are processed from the proglucagon polypeptide and secreted in equimolar amounts but have opposite effects on chylomicron (CM) production, with GLP-1 significantly reducing and GLP-2 increasing postprandia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::485d2bfff6aa701b6197dcc25cdd00b6
https://doi.org/10.2337/db12-0202
https://doi.org/10.2337/db12-0202
Autor:
Emi Yakushiji, Yasushi Sakata, M. Mahmood Hussain, Shizuya Yamashita, Carrie L. Welch, Daniel J. Rader, Joanne Hsieh, Liana Tascau, Marit Westerterp, Jahangir Iqbal, Matthew M. Molusky, Ikuyo Ichi, Alan R. Tall, Sandra Abramowicz, Masahiro Koseki, Shunichi Takiguchi
Publikováno v:
Atherosclerosis. 263:e82-e83
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d81a595b5a6abd05901499ee6b550e95
https://doi.org/10.1016/j.atherosclerosis.2017.06.268
https://doi.org/10.1016/j.atherosclerosis.2017.06.268