Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Joanne H. Heaton"'
Publikováno v:
Molecular Endocrinology. 27:754-768
MicroRNAs (miRNAs) are small, endogenous, non-protein–coding RNAs that are an important means of posttranscriptional gene regulation. Deletion of Dicer, a key miRNA processing enzyme, is embryonic lethal in mice, and tissue-specific Dicer deletion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f491e024996d5f47077f8e764749147
https://doi.org/10.1210/me.2012-1331
https://doi.org/10.1210/me.2012-1331
Autor:
Dafydd G. Thomas, Iberê C. Soares, Joanne H. Heaton, Gary D. Hammer, Derek P. Simon, Alex C. Kim, Antonio M. Lerario, Maria Candida Barisson Villares Fragoso, Ana Claudia Latronico, Lorena de Oliveira Lima, Thomas J. Giordano, Michelle A. Wood, Madson Q. Almeida, Rork Kuick, Ferdous M. Barlaskar, Elisabeth Starnes
Publikováno v:
The American Journal of Pathology. 181(3):1017-1033
Dysregulation of the WNT and insulin-like growth factor 2 (IGF2) signaling pathways has been implicated in sporadic and syndromic forms of adrenocortical carcinoma (ACC). Abnormal β-catenin staining and CTNNB1 mutations are reported to be common in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098b2c90a3c6792d3b080f1c05e268e2
Autor:
Edgar Ben-Josef, Aaron C. Spalding, Dafydd G. Thomas, Rork Kuick, Thomas J. Giordano, Alex C. Kim, Joanne H. Heaton, Ferdous M. Barlaskar, Gary D. Hammer
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 94:204-212
Context: Drug therapy for adrenocortical carcinoma (ACC), a rare and lethal malignancy, is largely empirical and ineffective. New treatments directed at molecular targets critical to the pathophysiology of ACC may prove more efficacious. Objective: T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad865925edf28ce39f141448c4e0f5d
https://doi.org/10.1210/jc.2008-1456
https://doi.org/10.1210/jc.2008-1456
Publikováno v:
Molecular Endocrinology. 20:1025-1034
TGFbeta is a major regulator of extracellular matrix deposition and a potent inducer of type-1 plasminogen activator inhibitor (PAI-1) gene expression. We have reported that liganded glucocorticoid receptor (GR) represses TGFbeta transactivation of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b4a8729e97b36f8a4acbb66abd4d12
https://doi.org/10.1210/me.2005-0145
https://doi.org/10.1210/me.2005-0145
Autor:
Joanne H. Heaton, Melissa E. Williams, Jeffrey W. Innis, Thomas D. Gelehrter, Thomas M. Williams
Publikováno v:
Nucleic Acids Research
Interactions with co-factors provide a means by which HOX proteins exert specificity. To identify candidate protein interactors of HOXA13, we created and screened an E11.5-E12.5, distal limb bud yeast two-hybrid prey library. Among the interactors, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb81129a63e3ed6dd31f81b2df62f6af
http://europepmc.org/articles/PMC1183491
http://europepmc.org/articles/PMC1183491
Publikováno v:
Thrombosis and Haemostasis. 89:959-966
SummaryThe plasminogen activator-plasmin cascade is involved in multiple physiological and pathological processes including fibrinolysis, wound healing, fibrosis, angiogenesis, embryo implantation and tumor cell invasion and metastasis. Plasminogen a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56d31f9618338316e296d69d7f0aa937
https://doi.org/10.1055/s-0037-1613396
https://doi.org/10.1055/s-0037-1613396
Publikováno v:
Journal of Biological Chemistry. 276:3341-3347
Incubation of HTC rat hepatoma cells with 8-bromo-cAMP results in a 3-fold increase in the rate of degradation of type-1 plasminogen activator inhibitor (PAI-1) mRNA. We have reported previously that the 3′-most 134 nt of the PAI-1 mRNA is able to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abf1b134270fb0a510fae41a3cf3ee1
https://doi.org/10.1074/jbc.m006538200
https://doi.org/10.1074/jbc.m006538200
Publikováno v:
Journal of Biological Chemistry. 274:1172-1179
Incubation of HTC rat hepatoma cells with the cyclic nucleotide analogue 8-bromo-cAMP results in a 3-fold increase in the rate of degradation of type-1 plasminogen activator-inhibitor (PAI-1) mRNA. Previous studies utilizing HTC cells stably transfec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b3a816cd03fe941558e8bae8c94c495
https://doi.org/10.1074/jbc.274.2.1172
https://doi.org/10.1074/jbc.274.2.1172
Publikováno v:
Journal of Biological Chemistry. 273:14261-14268
Type-1 plasminogen activator-inhibitor (PAI-1) is a major physiologic inhibitor of plasminogen activation. Incubation of HTC rat hepatoma cells with the cyclic nucleotide analogue, 8-bromo-cAMP, causes a dramatic increase in tissue-type plasminogen a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b17729e9bec3675fc7316f8e55a896dc
https://doi.org/10.1074/jbc.273.23.14261
https://doi.org/10.1074/jbc.273.23.14261
Publikováno v:
Endocrinology. 135:1195-1204
We have reported previously that tissue-type plasminogen activator (tPA) gene expression is regulated by glucocorticoids and cyclic nucleotides in HTC rat hepatoma cells. Incubation of HTC cells with the synthetic glucocorticoid dexamethasone (Dex) t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec0d6c5705b5ff159535e257a38ab0f
https://doi.org/10.1210/endo.135.3.8070363
https://doi.org/10.1210/endo.135.3.8070363