11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial

Autor: Nantia Othonos, Riccardo Pofi, Anastasia Arvaniti, Sarah White, Ilaria Bonaventura, Nikolaos Nikolaou, Ahmad Moolla, Thomas Marjot, Roland H. Stimson, André P. van Beek, Martijn van Faassen, Andrea M. Isidori, Elizabeth Bateman, Ross Sadler, Fredrik Karpe, Paul M. Stewart, Craig Webster, Joanne Duffy, Richard Eastell, Fatma Gossiel, Thomas Cornfield, Leanne Hodson, K. Jane Escott, Andrew Whittaker, Ufuk Kirik, Ruth L. Coleman, Charles A. B. Scott, Joanne E. Milton, Olorunsola Agbaje, Rury R. Holman, Jeremy W. Tomlinson

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Glucocorticoids prescribed to limit inflammation, have significant adverse effects. Here the authors show that co-administration of AZD4017 with prednisolone in men is a potential strategy to limit adverse glucocorticoid effects.

Externí odkaz: https://doaj.org/article/d5729cc721e9453cb5043aab11c131a3

Assessment of Cardiac Energy Metabolism, Function, and Physiology in Patients With Heart Failure Taking Empagliflozin:The Randomized, Controlled EMPA-VISION Trial

Autor: Moritz J. Hundertmark, Amanda Adler, Charalambos Antoniades, Ruth Coleman, Julian L. Griffin, Rury R. Holman, Hanan Lamlum, Jisoo Lee, Daniel Massey, Jack J.J.J. Miller, Joanne E. Milton, Shveta Monga, Ferenc E. Mózes, Areesha Nazeer, Betty Raman, Oliver Rider, Christopher T. Rodgers, Ladislav Valkovič, Eleanor Wicks, Masliza Mahmod, Stefan Neubauer

Publikováno v: Hundertmark, M J, Adler, A, Antoniades, C, Coleman, R, Griffin, J L, Holman, R R, Lamlum, H, Lee, J, Massey, D, Miller, J J J J, Milton, J E, Monga, S, Mózes, F E, Nazeer, A, Raman, B, Rider, O, Rodgers, C T, Valkovič, L, Wicks, E, Mahmod, M & Neubauer, S 2023, ' Assessment of Cardiac Energy Metabolism, Function, and Physiology in Patients With Heart Failure Taking Empagliflozin : The Randomized, Controlled EMPA-VISION Trial ', Circulation, vol. 147, no. 22, pp. 1654-1669 . https://doi.org/10.1161/CIRCULATIONAHA.122.062021

BACKGROUND: Sodium–glucose co-transporter 2 inhibitors (SGLT2i) have emerged as a paramount treatment for patients with heart failure (HF), irrespective of underlying reduced or preserved ejection fraction. However, a definite cardiac mechanism of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6991061491711a9400f62c93ebf46fa4
https://pure.au.dk/portal/da/publications/assessment-of-cardiac-energy-metabolism-function-and-physiology-in-patients-with-heart-failure-taking-empagliflozin(06821eb7-dc78-4441-a6b4-a23ac2bcfaf6).html

11β-Hydroxysteroid dehydrogenase type 1 inhibition protects against the development of adverse metabolic and bone effects of prednisolone: A randomized, double-blind, placebo-controlled trial

Autor: Jeremy Tomlinson, Rury R. Holman, Paul Stewart, Olorunsola F. Agbaje, Anastasia Arvaniti, Riccardo Pofi, Joanne E. Milton, Andrew Whittaker, Nantia Othonos, Ruth L. Coleman

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8652aef708d72b568d063237bfabf1fc
https://doi.org/10.1530/endoabs.70.oc3.6

Relationship of glycaemic index with cardiovascular risk factors: analysis of the National Diet and Nutrition Survey for people aged 65 and older

Autor: Claire E. Robertson, Ian J. Brown, Joanne E Milton, Gary Frost, Blandine Briche, Mary Hickson

Publikováno v: Public Health Nutrition. 10:1321-1335

ObjectiveTo identify associations between dietary glycaemic index (GI) and weight, body mass index and other risk factors for cardiovascular disease (CVD) – waist-to-hip ratio (WHR), lipoprotein fractions, triacylglycerols (TAG) and blood pressure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f2758fe5a961cd8563b6b8d5a1e0ab
https://doi.org/10.1017/s1368980007702914

Assessment of Cardiac Energy Metabolism, Function, and Physiology in Patients With Heart Failure Taking Empagliflozin: The Randomized, Controlled EMPA-VISION Trial.

Autor: Hundertmark, Moritz J., Adler, Amanda, Antoniades, Charalambos, Coleman, Ruth, Griffin, Julian L., Holman, Rury R., Lamlum, Hanan, Lee, Jisoo, Massey, Daniel, Miller, Jack J.J.J., Milton, Joanne E., Monga, Shveta, Mózes, Ferenc E., Nazeer, Areesha, Raman, Betty, Rider, Oliver, Rodgers, Christopher T., Valkovič, Ladislav, Wicks, Eleanor, Mahmod, Masliza

Publikováno v: Circulation; 5/30/2023, Vol. 147 Issue 22, p1654-1669, 16p