Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Joanne E Nettleship"'
Autor:
Petra Lukacik, C David Owen, Gemma Harris, Jani Reddy Bolla, Sarah Picaud, Irfan Alibay, Joanne E Nettleship, Louise E Bird, Raymond J Owens, Philip C Biggin, Panagis Filippakopoulos, Carol V Robinson, Martin A Walsh
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0256070 (2021)
Nontypeable Haemophilus influenzae (NTHi) is a significant pathogen in respiratory disease and otitis media. Important for NTHi survival, colonization and persistence in vivo is the Sap (sensitivity to antimicrobial peptides) ABC transporter system.
Externí odkaz:
https://doaj.org/article/3848955c7713409e903d25b26102d894
Autor:
Christian Tiede, Robert Bedford, Sophie J Heseltine, Gina Smith, Imeshi Wijetunga, Rebecca Ross, Danah AlQallaf, Ashley PE Roberts, Alexander Balls, Alistair Curd, Ruth E Hughes, Heather Martin, Sarah R Needham, Laura C Zanetti-Domingues, Yashar Sadigh, Thomas P Peacock, Anna A Tang, Naomi Gibson, Hannah Kyle, Geoffrey W Platt, Nicola Ingram, Thomas Taylor, Louise P Coletta, Iain Manfield, Margaret Knowles, Sandra Bell, Filomena Esteves, Azhar Maqbool, Raj K Prasad, Mark Drinkhill, Robin S Bon, Vikesh Patel, Sarah A Goodchild, Marisa Martin-Fernandez, Ray J Owens, Joanne E Nettleship, Michael E Webb, Michael Harrison, Jonathan D Lippiat, Sreenivasan Ponnambalam, Michelle Peckham, Alastair Smith, Paul Ko Ferrigno, Matt Johnson, Michael J McPherson, Darren Charles Tomlinson
Publikováno v:
eLife, Vol 6 (2017)
Molecular recognition reagents are key tools for understanding biological processes and are used universally by scientists to study protein expression, localisation and interactions. Antibodies remain the most widely used of such reagents and many sh
Externí odkaz:
https://doaj.org/article/703d31dbc0f14e0190b7ae2c2e80be55
Autor:
Jennifer Timm, Cristina Bosch-Navarrete, Eliseo Recio, Joanne E Nettleship, Heather Rada, Dolores González-Pacanowska, Keith S Wilson
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 5, p e0003781 (2015)
Leishmania spp. is a protozoan parasite and the causative agent of leishmaniasis. Thymidine kinase (TK) catalyses the transfer of the γ-phosphate of ATP to 2'-deoxythymidine (dThd) forming thymidine monophosphate (dTMP). L. major Type II TK (LmTK) h
Externí odkaz:
https://doaj.org/article/3756b357c9194de8b705af699ce4ab89
Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1.
Autor:
Victoria Arena de Souza, David J Scott, Joanne E Nettleship, Nahid Rahman, Michael H Charlton, Martin A Walsh, Raymond J Owens
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143919 (2015)
Human Carboxylesterase 1 (hCES1) is the key liver microsomal enzyme responsible for detoxification and metabolism of a variety of clinical drugs. To analyse the role of the single N-linked glycan on the structure and activity of the enzyme, authentic
Externí odkaz:
https://doaj.org/article/84e4838cf2134c1db34b616dbe6a427c
Autor:
Aksam Yassin, Riadh Talib, Khalid Al-Rumaihi, Joanne E. Nettleship, Bassam Albaba, Farid Saad, Mustafa Alwani, Daniel Kelly, Yousef Almehmadi
Publikováno v:
The Aging Male. 23:1553-1563
Non-alcoholic fatty liver disease (NAFLD) is associated with cardiovascular disease (CVD) and both are prevalent in men with testosterone deficiency. Long-term effects of testosterone therapy (TTh) on NAFLD are not well studied. This observational, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef463dfb9147022d5528b424749ca65f
https://doi.org/10.1080/13685538.2020.1867094
https://doi.org/10.1080/13685538.2020.1867094
Autor:
Ridwan Shabsigh, Joanne E. Nettleship
Publikováno v:
Health Crisis Management in Acute Care Hospitals ISBN: 9783030958053
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffe1eee6921131d7f0a2cdfb372294dc
https://doi.org/10.1007/978-3-030-95806-0_20
https://doi.org/10.1007/978-3-030-95806-0_20
Autor:
Joanne E. Nettleship, Aksam Yassin, Ahmad Al-Qudimat, Omar M. Aboumarzouk, Raed M. Al-Zoubi, Ridwan Shabsigh, Daniel Kelly, Mustafa Alwani
Publikováno v:
Reviews in Medical Virology
Summary The current coronavirus disease (COVID‐19) pandemic caused by novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has a male bias in severity and mortality. This is consistent with previous coronavirus pandemics such as S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89cf6a04e52ccf21766beeeab9d706e9
https://doi.org/10.1002/rmv.2223
https://doi.org/10.1002/rmv.2223
Autor:
Joanne E. Nettleship, Martin A. Walsh, Panagis Filippakopoulos, Sarah Picaud, Philip C. Biggin, Gemma Harris, Louise E. Bird, Petra Lukacik, Carol V. Robinson, Irfan Alibay, C. David Owen, Raymond J. Owens, Jani Reddy Bolla
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0256070 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10 (2021)
Nontypeable Haemophilus influenzae (NTHi) is a significant pathogen in respiratory disease and otitis media. Important for NTHi survival, colonization and persistence in vivo is the Sap (sensitivity to antimicrobial peptides) ABC transporter system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43947534db5a9690a6847f30f538eff4
https://doaj.org/article/3848955c7713409e903d25b26102d894
https://doaj.org/article/3848955c7713409e903d25b26102d894
Autor:
Zoja Soloviev, Joshua M.A. Bullock, Juliette M.B. James, Andrea C. Sauerwein, Joanne E. Nettleship, Raymond J. Owens, D. Flemming Hansen, Maya Topf, Konstantinos Thalassinos
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1870:140759
Human Histone Deacetylase 2 (HDAC2) belongs to a conserved enzyme superfamily that regulates deacetylation inside cells. HDAC2 is a drug target as it is known to be upregulated in cancers and neurodegenerative disorders. It consists of globular deace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a3ddf48566bf63d52afc8673e0d1b0
https://doi.org/10.1016/j.bbapap.2022.140759
https://doi.org/10.1016/j.bbapap.2022.140759
Autor:
Robin L. Owen, Joanne E. Nettleship, Thomas Simon, Angeliki Ditsiou, Shivani Soni, Laurence H. Pearl, Chrisostomos Prodromou, Athanasios Papakyriakou, John Spencer, Maria Chiara Iachini, Lihong Zhou, Leanne Milton-Harris, Teresa Gagliano, Jae Ho Lo, Goar Smbatyan, Heinz-Josef Lenz, Sahir Khurshid, Storm Hassell-Hart, Philip Carter, Raymond J. Owens, Naomi E. Chayen, Georgios Giamas, Viviana Vella, Apostolos Klinakis, Panagiota Ntavelou, S. Mark Roe, Justin Stebbing, Chiara Cilibrasi, Nikiana Simigdala
Publikováno v:
Science Advances
The structure of oncogenic LMTK3 determines its role and functions allowing drug inhibition as a new therapeutic strategy.
Elucidating signaling driven by lemur tyrosine kinase 3 (LMTK3) could help drug development. Here, we solve the crystal st
Elucidating signaling driven by lemur tyrosine kinase 3 (LMTK3) could help drug development. Here, we solve the crystal st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218bf1104e6c0496d79e2bad312b2532
http://hdl.handle.net/10044/1/84171
http://hdl.handle.net/10044/1/84171