Zobrazeno 1 - 10
of 339
pro vyhledávání: '"Joanne E Curran"'
Autor:
Madison Caballero, Daniel N Seidman, Ying Qiao, Jens Sannerud, Thomas D Dyer, Donna M Lehman, Joanne E Curran, Ravindranath Duggirala, John Blangero, Shai Carmi, Amy L Williams
Publikováno v:
PLoS Genetics, Vol 15, Iss 12, p e1007979 (2019)
Simulations of close relatives and identical by descent (IBD) segments are common in genetic studies, yet most past efforts have utilized sex averaged genetic maps and ignored crossover interference, thus omitting features known to affect the breakpo
Externí odkaz:
https://doaj.org/article/be224e2351de4e08be3c91ba89310c9f
Autor:
Gareth Hawkes, Robin N. Beaumont, Zilin Li, Ravi Mandla, Xihao Li, Christine M. Albert, Donna K. Arnett, Allison E. Ashley-Koch, Aneel A. Ashrani, Kathleen C. Barnes, Eric Boerwinkle, Jennifer A. Brody, April P. Carson, Nathalie Chami, Yii-Der Ida Chen, Mina K. Chung, Joanne E. Curran, Dawood Darbar, Patrick T. Ellinor, Myrian Fornage, Victor R. Gordeuk, Xiuqing Guo, Jiang He, Chii-Min Hwu, Rita R. Kalyani, Robert Kaplan, Sharon L. R. Kardia, Charles Kooperberg, Ruth J. F. Loos, Steven A. Lubitz, Ryan L. Minster, Take Naseri, Satupa’itea Viali, Braxton D. Mitchell, Joanne M. Murabito, Nicholette D. Palmer, Bruce M. Psaty, Susan Redline, M. Benjamin Shoemaker, Edwin K. Silverman, Marilyn J. Telen, Scott T. Weiss, Lisa R. Yanek, Hufeng Zhou, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Ching-Ti Liu, Kari E. North, Anne E. Justice, Jonathan M. Locke, Nick Owens, Anna Murray, Kashyap Patel, Timothy M. Frayling, Caroline F. Wright, Andrew R. Wood, Xihong Lin, Alisa Manning, Michael N. Weedon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The role of rare non-coding variation in complex human phenotypes is still largely unknown. To elucidate the impact of rare variants in regulatory elements, we performed a whole-genome sequencing association analysis for height using 333,100
Externí odkaz:
https://doaj.org/article/b2e3a91ecb614324b7f2fdd7370d5155
Autor:
Hemant Kulkarni, Manju Mamtani, Juan Peralta, Marcio Almeida, Thomas D Dyer, Harald H Goring, Matthew P Johnson, Ravindranath Duggirala, Michael C Mahaney, Rene L Olvera, Laura Almasy, David C Glahn, Sarah Williams-Blangero, Joanne E Curran, John Blangero
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151177 (2016)
While the role of type 2 diabetes (T2D) in inducing endothelial dysfunction is fairly well-established the etiological role of endothelial dysfunction in the onset of T2D is still a matter of debate. In the light of conflicting evidence in this regar
Externí odkaz:
https://doaj.org/article/8f78fe2da821447da3e0cb07443a0562
Autor:
Miles C Benton, Rodney A Lea, Donia Macartney-Coxson, Michelle Hanna, David A Eccles, Melanie A Carless, Geoffrey K Chambers, Claire Bellis, Harald H Goring, Joanne E Curran, Jacquie L Harper, Gregory Gibson, John Blangero, Lyn R Griffiths
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005593 (2015)
Multiphenotype genome-wide association studies (GWAS) may reveal pleiotropic genes, which would remain undetected using single phenotype analyses. Analysis of large pedigrees offers the added advantage of more accurately assessing trait heritability,
Externí odkaz:
https://doaj.org/article/ccfcc9d1d99441e2af3686a25a827852
Autor:
Amy L Williams, Giulio Genovese, Thomas Dyer, Nicolas Altemose, Katherine Truax, Goo Jun, Nick Patterson, Simon R Myers, Joanne E Curran, Ravi Duggirala, John Blangero, David Reich, Molly Przeworski, on behalf of the T2D-GENES Consortium
Publikováno v:
eLife, Vol 4 (2015)
Although the past decade has seen tremendous progress in our understanding of fine-scale recombination, little is known about non-crossover (NCO) gene conversion. We report the first genome-wide study of NCO events in humans. Using SNP array data fro
Externí odkaz:
https://doaj.org/article/16ae6f379cf3443e882d52a9a291051f
Autor:
Aleksandar Dakic, Jingqin Wu, Tingting Wang, Kevin Huynh, Natalie Mellett, Thy Duong, Habtamu B. Beyene, Dianna J. Magliano, Jonathan E. Shaw, Melinda J. Carrington, Michael Inouye, Jean Y. Yang, Gemma A. Figtree, Joanne E. Curran, John Blangero, John Simes, LIPID Study Investigators, Corey Giles, Peter J. Meikle
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Recent advancements in plasma lipidomic profiling methodology have significantly increased specificity and accuracy of lipid measurements. This evolution, driven by improved chromatographic and mass spectrometric resolution of newer platform
Externí odkaz:
https://doaj.org/article/a03d736de0b4446abc98e446b08e5043
Autor:
Deidre A Winnier, Marcel Fourcaudot, Luke Norton, Muhammad A Abdul-Ghani, Shirley L Hu, Vidya S Farook, Dawn K Coletta, Satish Kumar, Sobha Puppala, Geetha Chittoor, Thomas D Dyer, Rector Arya, Melanie Carless, Donna M Lehman, Joanne E Curran, Douglas T Cromack, Devjit Tripathy, John Blangero, Ravindranath Duggirala, Harald H H Göring, Ralph A DeFronzo, Christopher P Jenkinson
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0119941 (2015)
Type 2 diabetes (T2D) is a complex metabolic disease that is more prevalent in ethnic groups such as Mexican Americans, and is strongly associated with the risk factors obesity and insulin resistance. The goal of this study was to perform whole genom
Externí odkaz:
https://doaj.org/article/1149717880ac45b7bf59e56c0d6934a1
Autor:
Venkata Saroja eVoruganti, Jack W Kent, Subrata eDebnath, Shelley A Cole, Karin eHaack, Harald HH Goring, Melanie A Carless, Joanne E Curran, Matthew P Johnson, Laura eAlmasy, Thomas D Dyer, Jean W MacCluer, Eric K Moses, Hanna E Abboud, Michael C Mahaney, John eBlangero, Anthony Gean Comuzzie
Publikováno v:
Frontiers in Genetics, Vol 4 (2013)
Increased serum uric acid (SUA) is a risk factor for gout and renal and cardiovascular disease. The purpose of this study was to identify genetic factors that affect the variation in SUA in 632 Mexican Americans participants of the San Antonio Family
Externí odkaz:
https://doaj.org/article/0ceefc2e4e444682a5ffed233e41c40c
Autor:
Manju Mamtani, Hemant Kulkarni, Thomas D Dyer, Laura Almasy, Michael C Mahaney, Ravindranath Duggirala, Anthony G Comuzzie, John Blangero, Joanne E Curran
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59153 (2013)
In spite of the growing recognition of the specific association of waist circumference (WC) with type 2 diabetes (T2D) and insulin resistance (IR), current guidelines still use body mass index (BMI) as a tool of choice. Our objective was to determine
Externí odkaz:
https://doaj.org/article/723ee03a56b04afd992161308d0eec90
Autor:
Melanie A Carless, Hemant Kulkarni, Mark Z Kos, Jac Charlesworth, Juan M Peralta, Harald H H Göring, Joanne E Curran, Laura Almasy, Thomas D Dyer, Anthony G Comuzzie, Michael C Mahaney, John Blangero
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73950 (2013)
Several studies have identified effects of genetic variation on DNA methylation patterns and associated heritability, with research primarily focused on Caucasian individuals. In this paper, we examine the evidence for genetic effects on DNA methylat
Externí odkaz:
https://doaj.org/article/58b965aa90ac448085f1100a57d42f75