Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Joanne C. Morris"'
Autor:
Terry K. Smith, Marija K. Zacharova, Gordon J. Florence, Stefanie K. Menzies, Lindsay B. Tulloch, Marie I. Thomson, Andrew L. Fraser, Elizabeth F. B. King, Joanne C. Morris, Eoin R. Gould
Publikováno v:
Chemmedchem
Neglected tropical diseases caused by parasitic infections are an ongoing and increasing concern. They are a burden to human and animal health, having the most devastating effect on the world′s poorest countries. Building upon our previously report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8e6f1d792dd488a2bb5f1e4565e36c
https://doi.org/10.1002/cmdc.201600210
https://doi.org/10.1002/cmdc.201600210
Autor:
Ross G. Murray, Raghava R. Vanga, Gordon J. Florence, Joanne C. Morris, Terry K. Smith, Jonathan D. Osler
Publikováno v:
Chemistry - A European Journal. 19:8309-8320
A highly stereocontrolled synthesis of (+)-chamuvarinin has been completed in 1.5 % overall yield over 20 steps. The key fragment coupling reactions were the addition of alkyne 8 to aldehyde 7 (under Felkin–Anh control), followed by the two step ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104eb4ad4a83b8d7ab010a6a5975d3b4
https://doi.org/10.1002/chem.201204527
https://doi.org/10.1002/chem.201204527
Autor:
Graeme Milligan, Leigh A. Stoddart, Evi Kostenis, Richard J. Ward, Joanne C. Morris, Christian Tränkle, Brian D. Hudson, Nicola J. Smith, David R. Adams, Irina G. Tikhonova, Trond Ulven
Publikováno v:
Smith, N J, Ward, R J, Stoddart, L A, Hudson, B D, Kostenis, E, Ulven, T, Morris, J C, Tränkle, C, Tikhonova, I G, Adams, D R & Milligan, G 2011, ' Extracellular loop 2 of the free Fatty Acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator ', Molecular Pharmacology, vol. 80, no. 1, pp. 163-73 . https://doi.org/10.1124/mol.110.070789
Allosteric agonists are powerful tools for exploring the pharmacology of closely related G protein-coupled receptors that have nonselective endogenous ligands, such as the short chain fatty acids at free fatty acid receptors 2 and 3 (FFA2/GPR43 and F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d37cdaefd737fa5717a6eadb8bfc55
https://doi.org/10.1124/mol.110.070789
https://doi.org/10.1124/mol.110.070789
Autor:
Lindsay Tulloch, Stefanie K. Menzies, Andrew L. Fraser, Eoin R. Gould, Joanne C. Morris, Elizabeth F. King, Marija K. Zacharova, Terry K. Smith, Gordon J. Florence
The acetogenin family of polyketides produced by annonaceacous plants has broad anti-microbial activity through its potent inhibition of mitochondrial complex I. We recently reported [Florence, Chem. Med. Chem. 9;2548 (2014)] the trypanocidal activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d20461751f281adbe0ddc804d06d78ac
Autor:
Gordon J. Florence, Andrew L. Fraser, Stefanie K. Menzies, Eoin R. Gould, Joanne C. Morris, Lindsay B. Tulloch, Elizabeth F. B. King, Terry K. Smith
Publikováno v:
ChemMedChem. 9(11)
Neglected tropical diseases remain a serious global health concern. Here, a series of novel bis-tetrahydropyran 1,4-triazole analogues based on the framework of chamuvarinin, a polyketide natural product isolated from the annonaceae plant species are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb6462adf5ca0a3d2ab1632437718ff
https://pubmed.ncbi.nlm.nih.gov/25145275
https://pubmed.ncbi.nlm.nih.gov/25145275
Autor:
Gordon J. Florence, Vanga R. Reddy, Ross G. Murray, Jonathan D. Osler, Joanne C. Morris, Terry K. Smith
Publikováno v:
Organic Letters
Supported by grants from EPSRC (EP/F011458/1) and The Wellcome Trust (086658). A stereocontrolled total synthesis of (+)-chamuvarinin, isolated from the root extract of Uvaria Chamae, utilizes a convergent modular strategy to construct the adjacently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b4afd8a053f7e55cd97739045eea0a
https://pubmed.ncbi.nlm.nih.gov/21174397
https://pubmed.ncbi.nlm.nih.gov/21174397
Autor:
Irina G. Tikhonova, Graeme Milligan, Trond Ulven, Nicola J. Smith, Richard J. Ward, Brian D. Hudson, David R. Adams, Leigh A. Stoddart, Evi Kostenis, Joanne C. Morris
Publikováno v:
Biophysical Journal. 100:52a
Understanding of orthosteric and allosteric communications in the G protein coupled receptors (GPCRs) at molecular level may lead to new strategies in rational design of selective and efficacious drugs. A recently de-orphanized GPCR, the free fatty a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0928625dbb69438bc7467e5c531b34c8
https://doi.org/10.1016/j.bpj.2010.12.483
https://doi.org/10.1016/j.bpj.2010.12.483