Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Joanne Buxton"'
Autor:
Joseph S. Warmus, Markus Boehm, David W. Piotrowski, Terri Hinchey, Joanne Buxton, Janice E. Chin, Ann M. Janssen, Kentaro Futatsugi, Allyn T. Londregan, Philip A. Carpino, Nicole S. Roush
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1407-1411
Optimization of a high-throughput screening hit led to the discovery of a new series of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as highly potent agonists of TGR5. This novel chemotype was rapidly developed through iterative combinatorial li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc843cd3afae23d85020b3a102b77e5f
https://doi.org/10.1016/j.bmcl.2012.12.076
https://doi.org/10.1016/j.bmcl.2012.12.076
Autor:
Martin B. Brenner, Joseph S. Warmus, Jeffrey S. Dubins, Liuqing Wei, Janice E. Chin, Nicole S. Roush, David Hepworth, Angela Wolford, Mei Li, Sophie Y. Lavergne, Sandra M. Jennings, Wenhua Jiao, Kevin B. Bahnck, Denise Gautreau, David W. Piotrowski, Joanne Buxton, John R. Hadcock, Matthew F. Sammons, Declan Flynn, Michael Herr, Benjamin D. Stevens, Steven B. Coffey, Kentaro Futatsugi, Michael John Munchhof, Jian Wang, Terri Hinchey, Suvi T. M. Orr, Gregory Storer, Angel Guzman-Perez, Bryan Li, Ann M. Janssen
Publikováno v:
MedChemComm. 4:205-210
Reported herein is a medicinal chemistry effort towards the identification of orally available TGR5 agonist 12, which served as a dog tool compound for studies to increase confidence in this mechanism. With the challenge of striking the balance of TG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::560e0ccd3dee512e49d267735aed6db4
https://doi.org/10.1039/c2md20174g
https://doi.org/10.1039/c2md20174g
Autor:
Joseph S. Warmus, Steven B. Coffey, John R. Hadcock, Liuqing Wei, Kevin Daniel Freeman-Cook, Martin B. Brenner, Kentaro Futatsugi, Suvi T. M. Orr, Nicole S. Roush, Angela Wolford, David W. Piotrowski, David Hepworth, Joanne Buxton, Sophie Y. Lavergne, Michael Herr, Gregory Storer, Janice E. Chin, Jian Wang, Ann M. Janssen, Terri Hinchey, Raman Sharma, Allyn T. Londregan, Amit S. Kalgutkar, Sandra M. Jennings, Wenhua Jiao, Declan Flynn
Publikováno v:
ACS Medicinal Chemistry Letters. 4:63-68
Takeda G-protein-coupled receptor 5 (TGR5) represents an exciting biological target for the potential treatment of diabetes and metabolic syndrome. A new class of high-throughput screening (HTS)-derived tetrahydropyrido[4,3-d]pyrimidine amide TGR5 ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c1ccb53816b5ba5bdeba650b8b9692
https://doi.org/10.1021/ml300277t
https://doi.org/10.1021/ml300277t