Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Joanne Butterworth"'
Publikováno v:
Pilot and Feasibility Studies, Vol 6, Iss 1, Pp 1-16 (2020)
Abstract Background The number of older people with multiple health problems is increasing worldwide. This creates a strain on clinicians and the health service when delivering clinical care to this patient group, who themselves carry a large treatme
Externí odkaz:
https://doaj.org/article/b4a70e8148e0475aa57bad5e37eda9f8
Publikováno v:
The British journal of general practice : the journal of the Royal College of General Practitioners.
BackgroundAlthough shared decision making (SDM) is key to delivering patient-centred care, there are barriers to GPs implementing SDM in practice. SDM training is undergoing development by organisations, including the Royal College of General Practit
Autor:
Martin Coupal, Paul Jones, Lejla Hodzic, Wenhau Xiao, Edward Roberts, Andrew Griffin, Daniel Delorme, Dominic Salois, Maryse Labarre, Stephane St-Onge, Christopher Walpole, Jamie Boulet, Lars Gawell, Rico Lavoie, Joanne Butterworth, William Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5994-5998
We have investigated a series of phenolic diaryl amino piperidine delta opioid receptor agonists, establishing the importance of the phenol functional group and substitution on the piperdine nitrogen for delta agonist activity and selectivity versus
Autor:
Ralf Schmidt, Claude Godbout, Joanne Butterworth, Paul B. S. Clarke, Maryse Labarre, Kemal Payza, Graeme L. Fraser
Publikováno v:
Peptides. 20:1327-1335
AR-M100613 ([I]-Dmt-c[-D-Orn-2-Nal-D-Pro-D-Ala-]) is the iodinated analog of a cyclic casomorphin previously shown to be a potent antagonist at the delta opioid receptor. Specific [125I]AR-M100613 binding to rat whole brain membranes was saturable, r
Publikováno v:
Metabolic Brain Disease. 12:299-306
Numerous studies suggest that modifications in concentrations of both excitatory and inhibitory amino acids are implicated in the pathophysiology of portal-systemic encephalopathy (PSE), a neuropsychiatric disorder associated with chronic liver disea
Autor:
Joanne Butterworth, Malken Bayrakdarian, Vijayaratnam Santhakumar, Yun-Jin Hu, Tomaszewski Miroslaw
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(7)
2,4-Diaminopyrimidines derivatives were developed as a novel class of SNSR4 antagonists. Structure activity relationship of the diamino pyrimidine core was explored and a tool compound suitable for target validation was identified.
Publikováno v:
Advances in experimental medicine and biology. 611
Autor:
Ralf Schmidt, Vijayaratnam Santhakumar, Dajan O'Donnell, Joanne Butterworth, Mirek Tomaszewski
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9780387736563
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eac9b3e3d8993b349e336d1c36fb244d
https://doi.org/10.1007/978-0-387-73657-0_49
https://doi.org/10.1007/978-0-387-73657-0_49
Publikováno v:
Peptides: The Wave of the Future ISBN: 9789401039055
The heptadecapeptide nociceptin was identified as the ligand for the ORL1 (opioid receptor-like 1) receptor, which shares 60% sequence homology with the k opioid receptor. In contrast to the opioid peptides, the aromatic amino acid in position 1 can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::222b03c07325b5014a19de54d60ae257
https://doi.org/10.1007/978-94-010-0464-0_319
https://doi.org/10.1007/978-94-010-0464-0_319
Autor:
William Brown, Claude Godbout, Denis Projean, Bryan K. Takasaki, Ralf Schmidt, Joanne Butterworth, Wei Zhongyong, Helene Gagnon, Lars Gawell, Pierre-Emmanuel Morin, Chris Walpole, Daniel Delorme, Hua Yang, Julie Ducharme, Edward Roberts, Paul Jones, Maryse Labarre, Shi-Yi Yue, Andrea Jakob, Augustus Kamassah, Kemal Payza, Niklas Plobeck, Fei Zhou, Stephane St-Onge
Publikováno v:
Journal of medicinal chemistry. 43(21)
The design, synthesis, and pharmacological evaluation of a novel class of delta opioid receptor agonists, N, N-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide (6a) and its analogues, are described. These compounds, formally derived from SNC-80 (