Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Joanne B. Laub"'
Autor:
Frank P. DiNinno, Gregory P. Rouen, Jon G. Sundelof, Joanne B. Laub, Mark L. Greenlee, Joann Huber, Gail G. Hammond, Milton L. Hammond
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:3225-3230
The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced water solubility while maintaining potent activity against MRS. Introduction of a 1-β-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32811c5ac5a3f04df24eaa1c565a4afa
https://doi.org/10.1016/s0960-894x(99)00567-3
https://doi.org/10.1016/s0960-894x(99)00567-3
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2973-2976
A series of amidinium-substituted 2-dibenzofuranylcarbapenems with potent activity against MRSA has been synthesized via a Stille cross-coupling reaction. These new carbapenems show reduced serum protein binding and improved in vivo efficacy as a con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0cba274765990296a6392c59ca6997
https://doi.org/10.1016/s0960-894x(99)00526-0
https://doi.org/10.1016/s0960-894x(99)00526-0
Autor:
Frank P. DiNinno, Joann Huber, Jon G. Sundelof, Milton L. Hammond, Gail G. Hammond, Mark L. Greenlee, Joanne B. Laub, Gregory P. Rouen
Publikováno v:
ChemInform. 31
The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced water solubility while maintaining potent activity against MRS. Introduction of a 1-β-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adf205825e25b28594030ec37e68736b
https://doi.org/10.1002/chin.200008261
https://doi.org/10.1002/chin.200008261
Publikováno v:
ChemInform. 31
A series of amidinium-substituted 2-dibenzofuranylcarbapenems with potent activity against MRSA has been synthesized via a Stille cross-coupling reaction. These new carbapenems show reduced serum protein binding and improved in vivo efficacy as a con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e648f76be2cd1404a5e646db8f4f950f
https://doi.org/10.1002/chin.200007212
https://doi.org/10.1002/chin.200007212
Autor:
Katherine Young, Joann Huber, Gail G. Hammond, James M. Balkovec, David L. Pompliano, Lynn L. Silver, Joseph K. Wu, Mark L. Greenlee, KellyAnn D. Pryor, Barbara Leiting, Joanne B. Laub, Jeffrey H. Toney
Publikováno v:
FEMS microbiology letters. 179(2)
IMP-1 metallo-beta-lactamase is a transferable carbapenem-hydrolyzing enzyme found in some clinical isolates of Pseudomonas aeruginosa, Serratia marcescens and Klebsiella pneumoniae. Bacteria that express IMP-1 show significantly reduced sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b81fb410562095d2cbe2505f9f9689
https://pubmed.ncbi.nlm.nih.gov/10518728
https://pubmed.ncbi.nlm.nih.gov/10518728
Autor:
James M. Balkovec, Gail G. Hammond, Joanne B. Laub, David L. Pompliano, Jeffrey H. Epstein-Toney, Mark L. Greenlee, Milton L. Hammond
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(17)
Potent thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase have been synthesized employing a solid-phase Mitsunobu reaction as the key step.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb39c7cedaf22baeee5c7eb22d51c48
https://pubmed.ncbi.nlm.nih.gov/10498206
https://pubmed.ncbi.nlm.nih.gov/10498206