Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Joanne A Matsubara"'
Autor:
Justin R. Haynes, Clayton A. Whitmore, William J. Behof, Charlotte A. Landman, Henry H. Ong, Andrew P. Feld, Isabelle C. Suero, Celeste B. Greer, John C. Gore, Printha Wijesinghe, Joanne A. Matsubara, Brian E. Wadzinski, Benjamin W. Spiller, Wellington Pham
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The classical amyloid cascade hypothesis postulates that the aggregation of amyloid plaques and the accumulation of intracellular hyperphosphorylated Tau tangles, together, lead to profound neuronal death. However, emerging research has demo
Externí odkaz:
https://doaj.org/article/c762f9905491477abe67360110002bce
Autor:
Sieun Lee, Joanne Aiko Matsubara
Publikováno v:
Frontiers in Ophthalmology, Vol 4 (2024)
Externí odkaz:
https://doaj.org/article/2b47b3315b1b438cbb83d1db2da198ed
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Age-related macular degeneration (AMD), a prevalent and progressive degenerative disease of the macula, is the leading cause of blindness in elderly individuals in developed countries. The advanced stages include neovascular AMD (nAMD), characterized
Externí odkaz:
https://doaj.org/article/056aa4a011d84cbb818a71abb891ea97
Autor:
Yajian Duan, Wenyi Wu, Jing Cui, Joanne Aiko Matsubara, Andrius Kazlauskas, Gaoen Ma, Xiaorong Li, Hetian Lei
Publikováno v:
BMC Ophthalmology, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Epiretinal membranes in patients with proliferative vitreoretinopathy (PVR) consist of extracellular matrix and a number of cell types including retinal pigment epithelial (RPE) cells and fibroblasts, whose contraction causes reti
Externí odkaz:
https://doaj.org/article/57d4d7414a144c54ae9ff57857f0c767
Autor:
Qinyuan Alis Xu, Pierre Boerkoel, Veronica Hirsch-Reinshagen, Ian R. Mackenzie, Ging-Yuek Robin Hsiung, Geoffrey Charm, Elliott F. To, Alice Q. Liu, Katerina Schwab, Kailun Jiang, Marinko Sarunic, Mirza Faisal Beg, Wellington Pham, Jing Cui, Eleanor To, Sieun Lee, Joanne A. Matsubara
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-19 (2022)
Abstract Amyloid beta (Aβ) deposits in the retina of the Alzheimer’s disease (AD) eye may provide a useful diagnostic biomarker for AD. This study focused on the relationship of Aβ with macroglia and microglia, as these glial cells are hypothesiz
Externí odkaz:
https://doaj.org/article/ba3b05c1e6ed405c896afaf90c90c798
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Age-related macular degeneration (AMD) is a chronic and progressive inflammatory disease of the retina characterized by photoceptor loss and significant central visual impairment due to either choroidal neovascularization or geographic atrophy. The p
Externí odkaz:
https://doaj.org/article/7cd0c2f6e5a54010807acda3dbb35ab5
Autor:
Printha Wijesinghe, Clayton A. Whitmore, Matthew Campbell, Charles Li, Miranda Tsuyuki, Eleanor To, Justin Haynes, Wellington Pham, Joanne A. Matsubara
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionErgothioneine (Ergo) is a naturally occurring dietary antioxidant. Ergo uptake is dependent on the transporter, organic cation transporter novel-type 1 (OCTN1) distribution. OCTN1 is highly expressed in blood cells (myeloid lineage cells)
Externí odkaz:
https://doaj.org/article/0779f6bc2f6f4b919ed9fe12418178cc
Autor:
Eden Dubchak, Gideon Obasanmi, Matthew R. Zeglinski, David J. Granville, Sonia N. Yeung, Joanne A. Matsubara
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Age-related ocular diseases are the leading cause of blindness in developed countries and constitute a sizable socioeconomic burden worldwide. Age-related macular degeneration (AMD) and Fuchs endothelial corneal dystrophy (FECD) are some of the most
Externí odkaz:
https://doaj.org/article/49aec5773a9341299829b0061ba29bcb
Autor:
Ben Cardoen, Timothy Wong, Parsa Alan, Sieun Lee, Joanne Aiko Matsubara, Ivan Robert Nabi, Ghassan Hamarneh
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0276726 (2022)
Identification of small objects in fluorescence microscopy is a non-trivial task burdened by parameter-sensitive algorithms, for which there is a clear need for an approach that adapts dynamically to changing imaging conditions. Here, we introduce an
Externí odkaz:
https://doaj.org/article/32c38f7e899f4c45bd7e5f1902fce642
Publikováno v:
Frontiers in Medicine, Vol 8 (2022)
Pyroptosis is a gasdermin-mediated, pro-inflammatory form of cell death distinct from apoptosis. In recent years, increasing attention has shifted toward pyroptosis as more studies demonstrate its involvement in diverse inflammatory disease states, i
Externí odkaz:
https://doaj.org/article/12dabad640b54f9dad55d079263d7588