A Phase 2 clinical trial of PF-05212377 (SAM-760) in subjects with mild to moderate Alzheimer’s disease with existing neuropsychiatric symptoms on a stable daily dose of donepezil

Autor: Terence Fullerton, Brendon Binneman, William David, Marielle Delnomdedieu, James Kupiec, Peter Lockwood, Jessica Mancuso, Jeffrey Miceli, Joanne Bell

Publikováno v: Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-10 (2018)

Abstract Background Symptomatic benefits have been reported for 5-HT6 receptor antagonists in Alzheimer’s disease (AD) trials. SAM-760 is a potent and selective 5-HT6 receptor antagonist that has demonstrated central 5-HT6 receptor saturation in hu

Externí odkaz: https://doaj.org/article/cd2894dc000748f6acf781381a6cf8a7

Revisiting Criteria for Psychosis in Alzheimer’s Disease and Related Dementias: Toward Better Phenotypic Classification and Biomarker Research

Autor: Luis Agüera-Ortiz, Peter K. Panegyres, Corinne E. Fischer, Sanjeev Kumar, Dilip V. Jeste, Mary Sano, Joanne Bell, Fabrizia D'Antonio, Devangere P. Devanand, William J. McGeown, Marie Andrée Bruneau, Constantine G. Lyketsos, Zahinoor Ismail, R. Ryan Darby, Byron Creese, Nicolas A. Nunez, Jeffrey L. Cummings, Carlo de Lena, Clive Ballard, Antonella Di Vita, Huali Wang, Robert A. Sweet, Krista L. Lanctôt, Ravona Ramit, Jill Rasmussen, James M. Youakim

Publikováno v: Journal of Alzheimer's disease : JAD, vol 73, iss 3

Author(s): Fischer, Corinne E; Ismail, Zahinoor; Youakim, James M; Creese, Byron; Kumar, Sanjeev; Nunez, Nicolas; Ryan Darby, R; Di Vita, Antonella; D'Antonio, Fabrizia; de Lena, Carlo; McGeown, William J; Ramit, Ravona; Rasmussen, Jill; Bell, Joanne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e356600719d7c76a98f2cbfc45285402
https://doi.org/10.3233/jad-190828

Functional considerations in the conduct of clinical investigations in the adult Down syndrome population

Autor: Joanne Bell

Publikováno v: Alzheimer's & Dementia. 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::944157423214f172cc6566d4c59d265a
https://doi.org/10.1002/alz.043490

White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities

Autor: Sandra E. Black, Gene L. Bowman, Susanne J. van Veluw, Atticus H. Hainsworth, Douglas L. Rosene, Prashanthi Vemuri, Angela L. Jefferson, Timothy M. Hughes, Jeremy D. Isaacs, Donna M. Wilcock, Rebecca F. Gottesman, Kathleen M. Hayden, Jay C. Kwon, Laurel A. Beckett, C Elizabeth Shaaban, Sharon X. Xie, Walter Swardfager, Aron M. Troen, Henrieta Scholtzova, Jessica Alber, Allyson C. Rosen, Silke Kern, Geert Jan Biessels, Katie E. Osborn, Samuel N. Lockhart, Isabelle Bos, Heather M. Snyder, Suvarna Alladi, Jacqueline A. Rondeau, Alex M. Helman, David Barton, Athene Lee, Juraj Kukolja, Deborah Gustafson, Brandy L. Callahan, Hanneke F.M. Rhodius-Meester, Alifiya Kapasi, Vladimir Hachinski, Emanuele Brai, Melinda C. Power, Cheryl L. Wellington, Sterling C. Johnson, Anne M. Murray, Narlon C. Boa Sorte Silva, Joanne Bell, Hee-Joon Bae, Anders Wallin, Adam M. Brickman, Silvia Fossati, Julie A. Schneider, Roderick A. Corriveau, Sara E. Berman, Brittani R. Price

Publikováno v: Alber, J, Alladi, S, Bae, H-J, Barton, D A, Beckett, L A, Bell, J M, Berman, S E, Biessels, G J, Black, S E, Bos, I, Bowman, G L, Brai, E, Brickman, A M, Callahan, B L, Corriveau, R A, Fossati, S, Gottesman, R F, Gustafson, D R, Hachinski, V, Hayden, K M, Helman, A M, Hughes, T M, Isaacs, J D, Jefferson, A L, Johnson, S C, Kapasi, A, Kern, S, Kwon, J C, Kukolja, J, Lee, A, Lockhart, S N, Murray, A, Osborn, K E, Power, M C, Price, B R, Rhodius-Meester, H F M, Rondeau, J A, Rosen, A C, Rosene, D L, Schneider, J A, Scholtzova, H, Shaaban, C E, Silva, N C B S, Snyder, H M, Swardfager, W, Troen, A M, van Veluw, S J, Vemuri, P, Wallin, A, Wellington, C, Wilcock, D M, Xie, S X & Hainsworth, A H 2019, ' White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities ', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 5, pp. 107-117 . https://doi.org/10.1016/j.trci.2019.02.001
Alzheimer's & Dementia : Translational Research & Clinical Interventions

White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cogn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4652e44b6a626a3e8cf05b920c3e595
https://openaccess.sgul.ac.uk/id/eprint/110686/16/1-s2.0-S2352873719300046-main.pdf

Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need

Autor: Jennifer J. Manly, Ralph N. Martins, Lon S. Schneider, Kerry Kilborn, Yakeel T. Quiroz, Scott M. Hofer, Robert A. Rissman, Octavio A. Santos, Hiroko H. Dodge, Steven D. Edland, Charlotte E. Teunissen, Ganesh M. Babulal, Hector M. González, Esther S. Oh, Donna M. Wilcock, Debora Melo van Lent, Michael Weinborn, Michelle M. Mielke, Carrie Ciro, Andre Strydom, James Hendrix, Catherine M. Roe, Roos J. Jutten, Graciela Muniz Terrera, Claudio Babiloni, Nicole Schupf, Melissa E. Murray, Benedict C. Albensi, Heather M. Snyder, Gaël Chételat, Gene L. Bowman, Elizabeth Head, Peggye Dilworth-Anderson, Anna J. Esbensen, Simone Dreux, Eider M. Arenaza-Urquijo, Adam M. Brickman, Sid E. O'Bryant, Mario A. Parra, Sietske A.M. Sikkes, Ann D. Cohen, Henrik Zetterberg, Martha Clare Morris, Leigh A. Johnson, Alex Bahar-Fuchs, Linda M.P. Wesselman, Lisbeth Evered, Keith N. Fargo, Joanne Bell, Arlene Astell, Juan Fortea, Michael Ewers, Nikolaos Scarmeas, Krista L. Lanctôt, Yaakov Stern, Hamid R. Sohrabi, Deborah Gustafson, Yi Tang

Publikováno v: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Wiley, 2019, 15 (2), pp.292-312. ⟨10.1016/j.jalz.2018.09.009⟩
Babulal, G, Strydom, A & O'Bryant, S 2019, ' Perspectives on Ethnic and Racial Disparities in Alzheimer's Disease and Related Dementias : Update and Areas of Immediate Need ', Alzheimers & Dementia, vol. 15, no. 2, pp. 292-312 . https://doi.org/10.1016/j.jalz.2018.09.009
Alzheimer's and dementia 15(2), 292-312 (2018). doi:10.1016/j.jalz.2018.09.009
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019, 15 (2), pp.292-312. ⟨10.1016/j.jalz.2018.09.009⟩
Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 15, iss 2
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Babulal, G M, Quiroz, Y T, Albensi, B C, Arenaza-Urquijo, E, Astell, A J, Babiloni, C, Bahar-Fuchs, A, Bell, J, Bowman, G L, Brickman, A M, Chételat, G, Ciro, C, Cohen, A D, Dilworth-Anderson, P, Dodge, H H, Dreux, S, Edland, S, Esbensen, A, Evered, L, Ewers, M, Fargo, K N, Fortea, J, Gonzalez, H, Gustafson, D R, Head, E, Hendrix, J A, Hofer, S M, Johnson, L A, Jutten, R, Kilborn, K, Lanctôt, K L, Manly, J J, Martins, R N, Mielke, M M, Morris, M C, Murray, M E, Oh, E S, Parra, M A, Rissman, R A, Roe, C M, Santos, O A, Scarmeas, N, Schneider, L S, Schupf, N, Sikkes, S, Snyder, H M, Sohrabi, H R, Stern, Y, Teunissen, C, Wesselman, L, Wilcock, D M, Zetterberg, H, O’Bryant, S E & International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association 2019, ' Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias : Update and areas of immediate need ', Alzheimer's and Dementia, vol. 15, no. 2, pp. 292-312 . https://doi.org/10.1016/j.jalz.2018.09.009
Babulal, GM; Quiroz, YT; Albensi, BC; Arenaza-Urquijo, E; Astell, AJ; Babiloni, C; et al.(2018). Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need. Alzheimer's and Dementia. doi: 10.1016/j.jalz.2018.09.009. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/1442b7sm

Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER), Unión Europea, "Una manera de hacer Europa", La "Marató TV3" grant (20141210 to J.F.) Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd78135d38b8890425e4bb7ccf733bbc
https://www.hal.inserm.fr/inserm-02747771/document