Foot-and-mouth disease virus localisation on follicular dendritic cells and sustained induction of neutralising antibodies is dependent on binding to complement receptors (CR2/CR1).

Autor: Lucy Gordon, Neil Mabbott, Joanna Wells, Liudmila Kulik, Nick Juleff, Bryan Charleston, Eva Perez-Martin

Publikováno v: PLoS Pathogens, Vol 18, Iss 5, p e1009942 (2022)

Previous studies have shown after the resolution of acute infection and viraemia, foot-and-mouth disease virus (FMDV) capsid proteins and/or genome are localised in the light zone of germinal centres of lymphoid tissue in cattle and African buffalo.

Externí odkaz: https://doaj.org/article/0491e520f37f4b9689b8552a64d5adcf

Pragmatic Design of Randomized Clinical Trials for Heart Failure

Autor: Stephen J. Greene, Eric J. Velazquez, Kevin J. Anstrom, Eric L. Eisenstein, Shelly Sapp, Shelby Morgan, Tina Harding, Vandana Sachdev, Fassil Ketema, Dong-Yun Kim, Patrice Desvigne-Nickens, Bertram Pitt, Robert J. Mentz, Kirkwood Adams, Tammy Long, Kunal Bhatt, Brandon Walker, Tracy DeWald, Kim Biever, Kelly Axsom, Ariana Acosta, Sandhya Murthy, Angeline Camilo, Jonathan D. Rich, Leslie Martinez, Jeffrey M. Testani, Jennifer Tainsh, Bryan Smith, Amy Bennett, Justin Vader, Stephanie Stilinovic, Michael McCulloch, Iris Musso, Hal Skopicki, Indre Caikauskaite, Mitchell A. Psotka, Allen Freiler, Alain Heroux, Carol Kartje, Anuradha Lala-Trindade, Lovelyne Julien, Gerin Stevens, Keriann Leppla, Wilson Tang, Teresa Fonk, Yair Lev, Kathleen Fizgerald, Preethi William, John Stroster, Arthur Eberly, Celeste Workman, Stephen Gottlieb, Mary Bowers-Lash, Walter Herbert Haught, Cynthia Abath, Gillian Grafton, Kelsey Neaton, Joshua Larned, Mara-Li Ortiz, Lokesh Tejwani, Tara Villalta, Freny Mody, Svetlana Strugatsky, Selim Krim, Katasha Washington, Monique Robinson, Nadine Norton, Frank Smart, Emily Worsham, James Fang, Joe Goldstein, Stephanie Dunlap, Nancy Starnes, Alexander Adler, Virginia Theodorof, Adrian Bell, Aleksey Kondramashin, Dipanjan Banerjee, Michael Yee, Ernesto Ruiz-Duque, Cynthia Larew, Ahmad Mizyed, Kara Sawaya, Dennis Friedman, Shilpa Rele, John Rommel, Janet Burkhart, Justice Arhinful, Sam Atkinson, Parag Goyal, Nidha Samdani, Michael Hall, Connie Watson, Scott Hummel, Joanna Wells, Sanjay Shetty, Jackie White, Donald Haas, Colleen Marchand, Juan Vilaro, Alfaroug Osman, Tamas Alexy, Julie Dicken, Maya Guglin, Meghan Willig, Andrew Ferguson, Mark Peabody, John Herre, Brittany McMichael, John Clark, Nancy Britton, Andrew P. Ambrosy, Thida Tan, John Heitner, Marcella Meykler, Judith Meadows, Janet Halliday

Publikováno v: JACC: Heart Failure. 9:325-335

Randomized clinical trials are the foundation of evidence-based medicine and central to practice guidelines and patient care decisions. Nonetheless, randomized trials in heart failure (HF) populations have become increasingly difficult to conduct and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c60544c3f97e82fb6e58b719b2b8231
https://doi.org/10.1016/j.jchf.2021.01.013

Foot-and-mouth disease virus localisation on follicular dendritic cells and sustained induction of neutralising antibodies is dependent on binding to complement receptors (CR2/CR1)

Autor: Neil A. Mabbott, Liudmila Kulik, Eva Pérez-Martín, Bryan Charleston, Joanna Wells, Nick Juleff, Lucy Gordon

Publikováno v: Gordon, L, Mabbott, N, Wells, J, Kulik, L, Juleff, N, Charleston, B & Perez-Martin, E 2022, ' Foot-and-mouth disease virus localisation on follicular dendritic cells and sustained induction of neutralising antibodies is dependent on binding to complement receptors (CR2/CR1) ', PLoS Pathogens, vol. 1009942, e1009942, pp. 1-27 . https://doi.org/10.1371/journal.ppat.1009942

Previous studies have shown after the resolution of acute infection and viraemia, foot- and-mouth disease virus (FMDV) capsid proteins and/or genome are localised in the light zone of germinal centres of lymphoid tissue in cattle and African buffalo.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24db7b1d106b77595c5f49624e973cad
https://pubmed.ncbi.nlm.nih.gov/35512014

Discrete virus factories form in the cytoplasm of cells co-infected with two strains of the segmented dsRNA virus, infectious bursal disease virus (IBDV), that subsequently coalesce

Autor: Joanna Wells, Pippa Hawes, Alice Gray, Elle A. Campbell, Jennifer Simpson, Andrew J. Broadbent

TheBirnaviridaefamily, responsible for major economic losses to poultry and aquaculture, are non-enveloped viruses with a segmented double-stranded (ds)RNA genome that replicate in discrete cytoplasmic virus factories (VFs). Reassortment is common, h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b26bc7a81ceff57ada4ec78c46960e9

Detecting Late Holocene cultural landscape modifications using LiDAR imagery in the Boreal Forest, Susitna Valley, Southcentral Alaska

Autor: Richard Martin, Brian T. Wygal, Joanna Wells, Kathryn E. Krasinski, Fran Seager-Boss

Publikováno v: Journal of Field Archaeology. 41:255-270

The subarctic boreal forest, or taiga, is the largest biome in the world but has received minimal archaeological research because of its remoteness and difficult working conditions. In Southcentral...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aba230e3030d5a2e7e4aed4bcad155b7
https://doi.org/10.1080/00934690.2016.1174764