Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Joanna Vrouvlianis"'
Autor:
Joy G. Ghosh, Andrew A. Nguyen, Chad E. Bigelow, Stephen Poor, Yubin Qiu, Nalini Rangaswamy, Richard Ornberg, Brittany Jackson, Howard Mak, Tucker Ezell, Vania Kenanova, Elisa de la Cruz, Ana Carrion, Bijan Etemad-Gilbertson, Roxana Garcia Caro, Kan Zhu, Vinney George, Jirong Bai, Radhika Sharma-Nahar, Siyuan Shen, Yiqin Wang, Kulandayan K. Subramanian, Elizabeth Fassbender, Michael Maker, Shawn Hanks, Joanna Vrouvlianis, Barrett Leehy, Debby Long, Melissa Prentiss, Viral Kansara, Bruce Jaffee, Thaddeus P. Dryja, Michael Roguska
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Retinal vascular disease treatments involve frequent pharmacological intraocular administrations. Here the authors present a method to increase the half-life of injected drugs by fusing these to a hyaluronan-binding peptide, which might lead to less
Externí odkaz:
https://doaj.org/article/f0adf43d440f4267b734d5d4506d7186
Autor:
Vivian W Choi, Chad E Bigelow, Terri L McGee, Akshata N Gujar, Hui Li, Shawn M Hanks, Joanna Vrouvlianis, Michael Maker, Barrett Leehy, Yiqin Zhang, Jorge Aranda, George Bounoutas, John T Demirs, Junzheng Yang, Richard Ornberg, Yu Wang, Wendy Martin, Kelly R Stout, Gregory Argentieri, Paul Grosenstein, Danielle Diaz, Oliver Turner, Bruce D Jaffee, Seshidhar R Police, Thaddeus P Dryja
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
Recessive mutations in RLBP1 cause a form of retinitis pigmentosa in which the retina, before its degeneration leads to blindness, abnormally slowly recovers sensitivity after exposure to light. To develop a potential gene therapy for this condition,
Externí odkaz:
https://doaj.org/article/543b664ff66b42138de04c51579aee00
Autor:
Timothy K. MacLachlan, Mark N. Milton, Oliver Turner, Francis Tukov, Vivian W. Choi, Jan Penraat, Shawn M. Hanks, Joanna Vrouvlianis, Barrett Leehy, Hui Li, Marie-Hélène Delmotte, Lydia Michaut, Bruce D. Jaffee, Chad E. Bigelow
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 8, Iss C, Pp 105-120 (2018)
Retinitis pigmentosa is a form of retinal degeneration usually caused by genetic mutations affecting key functional proteins. We have previously demonstrated efficacy in a mouse model of RLBP1 deficiency with a self-complementary AAV8 vector carrying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9da079374b6c787861fc32f57b6661
http://www.sciencedirect.com/science/article/pii/S2329050117301262
http://www.sciencedirect.com/science/article/pii/S2329050117301262
Autor:
Joanna Vrouvlianis, Xiaoqiu Wu, Christie L. Bell, Viral Kansara, Q Medley, Henry Y. Wu, Qian Huang, Hui Li, Terri L. McGee, Barrett Leehy, Vanessa Kainz, Melissa Prentiss, YongYao Xu, A.P. da Cunha, Qin Zhang, Chad E Bigelow, Nalini Rangaswamy
Publikováno v:
Current Eye Research. 43:553-565
The concept of tissue-dependent cytokine hierarchy has been demonstrated in a number of diseases, but it has not been investigated in ophthalmic diseases. Here, we evaluated the functional hierarchy of interleukin-1β (IL-1β), IL-6, IL-17A, and tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126d78ec285c21ad34a92b357b6f8c02
https://doi.org/10.1080/02713683.2017.1410180
https://doi.org/10.1080/02713683.2017.1410180
Autor:
Ana Carrion, Debby Long, Andrew Anh Nguyen, Michael Roguska, Elisa de la Cruz, Bruce D Jaffee, Stephen Poor, Kulandayan K. Subramanian, Bijan Etemad-Gilbertson, Vania Kenanova, Shawn Hanks, Roxana Garcia Caro, Nalini Rangaswamy, Kan Zhu, Barrett Leehy, Elizabeth Fassbender, Chad E Bigelow, Howard H. Mak, Joy Ghosh, Jirong Bai, Yubin Qiu, Viral Kansara, Radhika Sharma-Nahar, Siyuan Shen, Michael Maker, Melissa Prentiss, Brittany Jackson, Richard Ornberg, Joanna Vrouvlianis, Vinney George, Yiqin Wang, Tucker Ezell, Thaddeus P. Dryja
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nature Communications
Protein drugs that neutralize vascular endothelial growth factor (VEGF), such as aflibercept or ranibizumab, rescue vision in patients with retinal vascular diseases. Nonetheless, optimal visual outcomes require intraocular injections as frequently a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f28f1f2760d443ab436000b8e2eab1
https://doaj.org/article/f0adf43d440f4267b734d5d4506d7186
https://doaj.org/article/f0adf43d440f4267b734d5d4506d7186
Autor:
Barrett Leehy, Vanessa Davis, Valentin M. Sluch, Chad E Bigelow, Dennis S Rice, Angela Banks, Joanna Vrouvlianis, Jorge Aranda, Alexandra M. Hyman, Chuanxi Xiang, John Demirs, Junzheng Yang, Hui Li, Maura Crowley, Bo Chang, Shawn Hanks
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
The knockout (KO) of the adiponectin receptor 1 (AdipoR1) gene causes retinal degeneration. Here we report that ADIPOR1 protein is primarily found in the eye and brain with little expression in other tissues. Further analysis of AdipoR1 KO mice revea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e72c357f78437adb850e500493c866b
https://doi.org/10.1038/s41598-018-32579-9
https://doi.org/10.1038/s41598-018-32579-9
Autor:
Valentin M, Sluch, Angela, Banks, Hui, Li, Maura A, Crowley, Vanessa, Davis, Chuanxi, Xiang, Junzheng, Yang, John T, Demirs, Joanna, Vrouvlianis, Barrett, Leehy, Shawn, Hanks, Alexandra M, Hyman, Jorge, Aranda, Bo, Chang, Chad E, Bigelow, Dennis S, Rice
Publikováno v:
Scientific reports. 8(1)
The knockout (KO) of the adiponectin receptor 1 (AdipoR1) gene causes retinal degeneration. Here we report that ADIPOR1 protein is primarily found in the eye and brain with little expression in other tissues. Further analysis of AdipoR1 KO mice revea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c9f6f57d63d7036fe49dd11edb70eb7
https://pubmed.ncbi.nlm.nih.gov/30254279
https://pubmed.ncbi.nlm.nih.gov/30254279
Autor:
Kaori Ohtomo, Robin R. Hodges, Dayu Li, Marie A. Shatos, Joanna Vrouvlianis, Darlene A. Dartt
Publikováno v:
Investigative ophthalmologyvisual science. 52(13)
To isolate and characterize cultured myoepithelial cells (MECs) from rat lacrimal gland and determine which purinergic receptor subtypes are present and functional in MECs.Rat lacrimal glands were subjected to collagenase digestion, and MECs were gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae1187dbe7c7bd2a2df1633c7a868de
https://pubmed.ncbi.nlm.nih.gov/22039237
https://pubmed.ncbi.nlm.nih.gov/22039237
Publikováno v:
Investigative ophthalmologyvisual science. 52(6)
PURPOSE. To identify the type of purinergic receptors activated by adenosine triphosphate (ATP) in rat lacrimal gland and to determine their role in protein secretion. METHODS. Purinergic receptors were identified by RT-PCR, Western blot analysis, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5963a14a83109e31cd222b179c3740c
https://pubmed.ncbi.nlm.nih.gov/21421865
https://pubmed.ncbi.nlm.nih.gov/21421865
Publikováno v:
Investigative ophthalmologyvisual science. 47(8)
Purpose Although p42/p44 mitogen-activated protein kinase (MAPK) negatively modulates protein secretion stimulated by cholinergic and alpha(1D)-adrenergic agonists, it does not play a role in epidermal growth factor (EGF)-stimulated protein secretion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e734f4230d2dfcdba3b824b0f07e628
https://pubmed.ncbi.nlm.nih.gov/16877402
https://pubmed.ncbi.nlm.nih.gov/16877402