Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Joanna Suszyńska-Zajczyk"'
Autor:
Anna Kotowska-Zimmer, Lukasz Przybyl, Marianna Pewinska, Joanna Suszynska-Zajczyk, Dorota Wronka, Maciej Figiel, Marta Olejniczak
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 702-715 (2022)
Among the many proposed therapeutic strategies for Huntington's disease (HD), allele-selective therapies are the most desirable but also the most challenging. RNA interference (RNAi) tools that target CAG repeats selectively reduce the mutant hunting
Externí odkaz:
https://doaj.org/article/f010f7696caf4052a9f3bf981d0f4f3f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Hyperhomocysteinemia (HHcy), characterized by elevated homocysteine (Hcy) levels, is a known risk factor for cardiovascular, renal, and neurological diseases, as well as pregnancy complications. Our study aimed to investigate whether HHcy induced by
Externí odkaz:
https://doaj.org/article/c05efc88bd9e4d8a8247166223269762
Autor:
Łukasz Witucki, Kamila Borowczyk, Joanna Suszyńska-Zajczyk, Ewelina Warzych, Piotr Pawlak, Hieronim Jakubowski
Bleomycin hydrolase (BLMH), a homocysteine (Hcy)-thiolactone detoxifying enzyme, is attenuated in brains of Alzheimer’s disease patients. In mice, Blmh depletion causes astrogliosis and behavioral changes. Depletion of histone demethylase PHF8, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fe5b7697971e124fd3c32a25014e7ce
https://doi.org/10.1101/2023.03.20.533511
https://doi.org/10.1101/2023.03.20.533511
Autor:
Joanna, Perl A-Kaján, Agata, Malinowska, Jarosl Aw, Zimny, Dominik, Cysewski, Joanna, Suszyńska-Zajczyk, Hieronim, Jakubowski
Publikováno v:
Journal of proteome research. 20(5)
Protein
Publikováno v:
Molecular Genetics and Metabolism. 113:200-206
Scope Hyperhomocysteinemia (HHcy) is associated with kidney disease and leads to atherosclerosis and thrombosis. Paraoxonase 1 (Pon1), a hydrolase that participates in homocysteine (Hcy) metabolism and is carried in the circulation on high-density li
Publikováno v:
Journal of Alzheimer's Disease. 42:247-260
Homocysteine (Hcy) is a risk factor for Alzheimer's disease (AD). Paraoxonase 1 (Pon1) participates in Hcy metabolism and is also linked to AD. The inactivation of the Pon1 gene in mice causes the accumulation of Hcy-thiolactone in the brain and incr
Publikováno v:
Molecular Genetics and Metabolism. 112:339-346
Scope Hyperhomocysteinemia (HHcy) induced by dietary or genetic factors is linked to kidney disease. Bleomycin hydrolase (Blmh) metabolizes Hcy-thiolactone to Hcy. We aimed to explain the role of dietary HHcy in kidney disease. Methods and results We
Autor:
Lukasz Marczak, Dorota Formanowicz, Maria Wanic-Kossowska, Joanna Suszyńska-Zajczyk, Elżbieta Pawliczak, Maciej Stobiecki, Magdalena Luczak
Publikováno v:
International Journal of Molecular Sciences; Volume 17; Issue 5; Pages: 631
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 17, Iss 5, p 631 (2016)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 17, Iss 5, p 631 (2016)
The major cause of mortality in patients with chronic kidney disease (CKD) is atherosclerosis related to traditional and non-traditional risk factors. However, the understanding of the molecular specificity that distinguishes the risk factors for cla
Autor:
Łukasz Marczak, Elżbieta Pawliczak, Dorota Formanowicz, Joanna Suszyńska-Zajczyk, Maria Wanic-Kossowska, Maciej Stobiecki, Magdalena Luczak
Publikováno v:
Scientific Reports
Patients with chronic kidney disease (CKD) have a considerably higher risk of death due to cardiovascular causes. Using an iTRAQ MS/MS approach, we investigated the alterations in plasma protein accumulation in patients with CKD and classical cardiov
Publikováno v:
Journal of Alzheimer's disease : JAD. 40(3)
Homocysteine (Hcy) is a risk factor for Alzheimer's disease (AD). Bleomycin hydrolase (BLMH) participates in Hcy metabolism and is also linked to AD. The inactivation of the Blmh gene in mice causes accumulation of Hcy-thiolactone in the brain and in