Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Joanna Storer"'
Autor:
Rachel Eyre, Denis G. Alférez, Angélica Santiago-Gómez, Kath Spence, James C. McConnell, Claire Hart, Bruno M. Simões, Diane Lefley, Claudia Tulotta, Joanna Storer, Austin Gurney, Noel Clarke, Mick Brown, Sacha J. Howell, Andrew H. Sims, Gillian Farnie, Penelope D. Ottewell, Robert B. Clarke
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
In breast cancer, dormant cancer cells may develop into bone metastases. Here, the authors demonstrate that microenvironmental IL1β stimulates metastatic breast cancer cell colonisation in the bone via IL1β-NFKB/CREB-Wnt pathway activation and canc
Externí odkaz:
https://doaj.org/article/c9b7748a363e46eb80d945fea7c4be66
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Hematopoietic stem cells interact with bone marrow niches, including highly specialized blood vessels. Recent studies have revealed the phenotypic and functional heterogeneity of bone marrow endothelial cells. This has facilitated the analysis of the
Externí odkaz:
https://doaj.org/article/a17adb3b88eb49d38a801e90a5148d33
Autor:
Kristian Gurashi, Daniel H. Wiseman, Kiran Batta, Syed Murtuza Baker, Joanna Storer, Arundhati V Dongre, Tim C. P. Somervaille
Publikováno v:
Wiseman, D, Baker, S M, Dongre, A, Gurashi, K, Storer, J, Somervaille, T & Batta, K 2020, ' Chronic myelomonocytic leukaemia stem cell transcriptomes anticipate disease morphology and outcome ', EBioMedicine, vol. 58, 102904 . https://doi.org/10.1016/j.ebiom.2020.102904
EBioMedicine, Vol 58, Iss, Pp 102904-(2020)
EBioMedicine
EBioMedicine, Vol 58, Iss, Pp 102904-(2020)
EBioMedicine
Background Chronic myelomonocytic leukaemia (CMML) is a clinically heterogeneous stem cell malignancy with overlapping features of myelodysplasia and myeloproliferation. Over 90% of patients carry mutations in epigenetic and/or splicing genes, typica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d2e8f1a432a4230c6e6c31811dda77
https://research.manchester.ac.uk/en/publications/58d31977-3b18-4e57-9b0a-6516aed73885
https://research.manchester.ac.uk/en/publications/58d31977-3b18-4e57-9b0a-6516aed73885
Autor:
Rozanne M. Sandri-Goldin, Alexander P. Golovanov, Xiaochen Tian, Richard B. Tunnicliffe, Joanna Storer
Publikováno v:
Scientific Reports
Tunnicliffe, Richard B; Tian, Xiaochen; Storer, Joanna; Sandri-Goldin, Rozanne M; & Golovanov, Alexander P. (2018). Overlapping motifs on the herpes viral proteins ICP27 and ORF57 mediate interactions with the mRNA export adaptors ALYREF and UIF.. Scientific reports, 8(1), 15005. doi: 10.1038/s41598-018-33379-x. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5t9244zj
Tunnicliffe, R B, Tian, X, Storer, J, Sandri-Goldin, R M & Golovanov, A P 2018, ' Overlapping motifs on the herpes viral proteins ICP27 and ORF57 mediate interactions with the mRNA export adaptors ALYREF and UIF ', Scientific Reports, vol. 8, no. 1, pp. 15005 . https://doi.org/10.1038/s41598-018-33379-x
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Tunnicliffe, Richard B; Tian, Xiaochen; Storer, Joanna; Sandri-Goldin, Rozanne M; & Golovanov, Alexander P. (2018). Overlapping motifs on the herpes viral proteins ICP27 and ORF57 mediate interactions with the mRNA export adaptors ALYREF and UIF.. Scientific reports, 8(1), 15005. doi: 10.1038/s41598-018-33379-x. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5t9244zj
Tunnicliffe, R B, Tian, X, Storer, J, Sandri-Goldin, R M & Golovanov, A P 2018, ' Overlapping motifs on the herpes viral proteins ICP27 and ORF57 mediate interactions with the mRNA export adaptors ALYREF and UIF ', Scientific Reports, vol. 8, no. 1, pp. 15005 . https://doi.org/10.1038/s41598-018-33379-x
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
The TREX complex mediates the passage of bulk cellular mRNA export to the nuclear export factor TAP/NXF1 via the export adaptors ALYREF or UIF, which appear to act in a redundant manner. TREX complex recruitment to nascent RNA is coupled with 5′ ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e09c68eb69c8a13dab81ae42e1d0f7
https://pubmed.ncbi.nlm.nih.gov/30301920
https://pubmed.ncbi.nlm.nih.gov/30301920
Autor:
Mick D. Brown, Penelope D. Ottewell, Bruno M Simões, Austin Gurney, Robert Clarke, Diane V. Lefley, James C. McConnell, Andrew H. Sims, Kath Spence, Gillian Farnie, Sacha J Howell, Noel W. Clarke, Claudia Tulotta, Joanna Storer, Angélica Santiago-Gómez, Claire A Hart, Rachel Eyre, D Alferez
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Eyre, R, Alferez-Castro, D, Santiago-Gómez, A, Spence, K, Mcconnell, J, Hart, C, M Simoes, B, Lefley, D, Tulotta, C, Storer, J, Gurney, A, Clarke, N, Brown, M, Howell, S, Sims, A H, Farnie, G, Ottewell, P D & Clarke, R B 2019, ' Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling ', Nature Communications, vol. 10, no. 1, pp. 5016 . https://doi.org/10.1038/s41467-019-12807-0
Nature Communications
Eyre, R, Alferez-Castro, D, Santiago-Gómez, A, Spence, K, Mcconnell, J, Hart, C, M Simoes, B, Lefley, D, Tulotta, C, Storer, J, Gurney, A, Clarke, N, Brown, M, Howell, S, Sims, A H, Farnie, G, Ottewell, P D & Clarke, R B 2019, ' Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling ', Nature Communications, vol. 10, no. 1, pp. 5016 . https://doi.org/10.1038/s41467-019-12807-0
Dissemination of tumour cells to the bone marrow is an early event in breast cancer, however cells may lie dormant for many years before bone metastases develop. Treatment for bone metastases is not curative, therefore new adjuvant therapies which pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ed58674a23e7277f076ffaad6634b7