Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Joanna S Remack"'
Autor:
Karina Jin Yoon, Doris A Phelps, Rebecca A Bush, Joanna S Remack, Catherine A Billups, Joseph D Khoury
Publikováno v:
PLoS ONE, Vol 3, Iss 11, p e3629 (2008)
The actin cytoskeleton is a primary determinant of tumor cell motility and metastatic potential. Motility and metastasis are thought to be regulated, in large part, by the interaction of membrane proteins with cytoplasmic linker proteins and of these
Externí odkaz:
https://doaj.org/article/40fa94eba2c04e359db09a3f00034b00
Autor:
Karen S Aboody, Rebecca A Bush, Elizabeth Garcia, Marianne Z Metz, Joseph Najbauer, Kristine A Justus, Doris A Phelps, Joanna S Remack, Karina Jin Yoon, Shanna Gillespie, Seung U Kim, Carlotta A Glackin, Philip M Potter, Mary K Danks
Publikováno v:
PLoS ONE, Vol 1, p e23 (2006)
Patients diagnosed with metastatic cancer have almost uniformly poor prognoses. The treatments available for patients with disseminated disease are usually not curative and have side effects that limit the therapy that can be given. A treatment that
Externí odkaz:
https://doaj.org/article/fbdc182300744ae18ba3c46343dfa818
Autor:
Joseph Najbauer, Monika Wierdl, Seung U. Kim, Mary K. Danks, Marianne Z. Metz, Rebecca A. Bush, Joanna S. Remack, Lyudmila Tsurkan, Karen S. Aboody, K. Jin Yoon, Elizabeth Garcia, Philip M. Potter
Publikováno v:
Cancer Research. 67:22-25
Neural stem cells and progenitor cells migrate selectively to tumor loci in vivo. We exploited the tumor-tropic properties of HB1.F3.C1 cells, an immortalized cell line derived from human fetal telencephalon, to deliver the cDNA encoding a secreted f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737d80e7ac4b175efe95c9a935dc97d2
https://doi.org/10.1158/0008-5472.can-06-3607
https://doi.org/10.1158/0008-5472.can-06-3607
Autor:
Samuel A. Wells, Klaus K.-F. Herfarth, Joanna S. Remack, Paul J. Goodfellow, Thomas P. Brent, Ira J. Kodner, Rebecca P. Danam
Publikováno v:
Molecular Carcinogenesis. 24:90-98
The enzyme O6-methylguanine-DNA methyltransferase (MGMT) protects cells from the cytotoxic and mutagenic effects of alkylating agents. Approximately 20% of tumor cell lines lack MGMT activity and are highly sensitive to alkylating agents. In establis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ee59dc66406dead00bcf8bce1b1ff90
https://doi.org/10.1002/(sici)1098-2744(199902)24:2<90::aid-mc3>3.0.co
https://doi.org/10.1002/(sici)1098-2744(199902)24:2<90::aid-mc3>3.0.co
Publikováno v:
Proceedings of the National Academy of Sciences. 94:4348-4353
O 6 -Methylguanine-DNA methyltransferase (MGMT), an enzyme that repairs adducts at O 6 of guanine in DNA, is a major determinant of susceptibility to simple methylating carcinogens or of tumor response to anticancer chloroethylating drugs. To investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17ce05d5ab73d497fa7a5f890ed982c
https://doi.org/10.1073/pnas.94.9.4348
https://doi.org/10.1073/pnas.94.9.4348
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1217:141-146
Approx. 20% of human tumor cell lines (termed Mer−) are deficient in the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT; E.C.2.1.1.63). Such cells possess the MGMT gene and promoter sequences but have virtually no mRNA or protein. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f3c4008d83bab2152ea77840ed9550
https://doi.org/10.1016/0167-4781(94)90027-2
https://doi.org/10.1016/0167-4781(94)90027-2
Publikováno v:
Nucleic Acids Research. 22:4614-4619
The DNA repair enzyme, O6-methylguanine DNA methyltransferase (MGMT) is responsible for repair of damage induced by alkylating agents that produce adducts at O6-guanine in DNA. Although the MGMT gene promoter has housekeeping gene promoter characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a605e85544a09438a771cffabf89d028
https://doi.org/10.1093/nar/22.22.4614
https://doi.org/10.1093/nar/22.22.4614
Publikováno v:
Mutation Research/DNA Repair. 255:175-182
Transfection of Chinese hamster ovary (CHO) cells with human DNA has been shown in several laboratories to produce clones which stably express the DNA-repair protein, O6-methylguanine-DNA methyltransferase (MGMT), that is lacking in the parent cell l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29607277026779b10d493f6c0600414c
https://doi.org/10.1016/0921-8777(91)90051-p
https://doi.org/10.1016/0921-8777(91)90051-p
Autor:
Joseph Khoury, Joanna S. Remack, Rebecca A. Bush, Karina J. Yoon, Doris A. Phelps, Catherine A. Billups
Publikováno v:
PLoS ONE, Vol 3, Iss 11, p e3629 (2008)
PLoS ONE
PLoS ONE
The actin cytoskeleton is a primary determinant of tumor cell motility and metastatic potential. Motility and metastasis are thought to be regulated, in large part, by the interaction of membrane proteins with cytoplasmic linker proteins and of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dd6d63adc8218879a7ac64db3162c8
http://europepmc.org/articles/PMC2575377?pdf=render
http://europepmc.org/articles/PMC2575377?pdf=render
Autor:
Jianjun Qi, Richard E. Lee, Philip M. Potter, M. Jason Hatfield, Joanna S. Remack, Kristopher G. Virga, Mary K. Danks, K. Jin Yoon
Publikováno v:
Molecular cancer therapeutics. 5(6)
Enzyme-prodrug approaches to cancer therapy, theoretically, have the potential to mediate tumor-selective cytotoxicity. However, even if tumor-specific prodrug activation is achieved, enzyme-prodrug systems investigated thus far comprised a single en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56d7094737e536411c26434406594ee
https://pubmed.ncbi.nlm.nih.gov/16818517
https://pubmed.ncbi.nlm.nih.gov/16818517