Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Joanna Romanowska"'
Autor:
Małgorzata Pietrowska-Borek, Jędrzej Dobrogojski, Anna Maria Wojdyła-Mamoń, Joanna Romanowska, Justyna Gołębiewska, Sławomir Borek, Koichi Murata, Atsushi Ishihara, Maria Ángeles Pedreño, Andrzej Guranowski
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13567 (2021)
It is known that cells contain various uncommon nucleotides such as dinucleoside polyphosphates (NpnN’s) and adenosine 5′-phosphoramidate (NH2-pA) belonging to nucleoside 5′-phosphoramidates (NH2-pNs). Their cellular levels are enzymatically co
Externí odkaz:
https://doaj.org/article/76a5931c980a431b88954ca8dbede660
Publikováno v:
Applied Sciences, Vol 11, Iss 5, p 2248 (2021)
This review provides a short account of the chemical synthesis of nucleoside di- and triphosphates on a historical background, together with the use of this class of compounds as potential pronucleotides in anti-HIV therapy.
Externí odkaz:
https://doaj.org/article/e7a76ddefa7b4c428decb30dc7019973
Publikováno v:
Molecules, Vol 17, Iss 12, Pp 14174-14185 (2012)
Biotin is an important molecule for modern biological studies including, e.g., cellular transport. Its exclusive affinity to fluorescent streptavidin/avidin proteins allows ready and specific detection. As a consequence methods for the attachment of
Externí odkaz:
https://doaj.org/article/0fb000df0b684b699b0c24f821c1faa6
Autor:
Joanna Romanowska, Justyna Gołębiewska, Michal Sobkowski, Krystian Kolodziej, Tomasz Jakubowski, Marta Rachwalak, Jerzy Boryski, Aleksandra Dabrowska, Adam Kraszewski, Jacek Stawinski
Publikováno v:
European Journal of Medicinal Chemistry. 164:47-58
We have designed a new type of AZT and ddU phosphoramidate diesters containing various combinations of 2-, 3-, 4-aminopyridine and 2-, 3-, 4-hydroxypyridine moieties attached to the phosphorus center, as potential anti-HIV pronucleotides. Depending o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4708d049c559aac488e3aa03cb1d84f
https://doi.org/10.1016/j.ejmech.2018.12.038
https://doi.org/10.1016/j.ejmech.2018.12.038
Publikováno v:
Applied Sciences, Vol 11, Iss 2248, p 2248 (2021)
This review provides a short account of the chemical synthesis of nucleoside di- and triphosphates on a historical background, together with the use of this class of compounds as potential pronucleotides in anti-HIV therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5215222301c9185525ba3eb8e1530ae4
https://www.mdpi.com/2076-3417/11/5/2248
https://www.mdpi.com/2076-3417/11/5/2248
Autor:
Justyna Gołębiewska, Joanna Romanowska, Tomasz Jakubowski, Michal Sobkowski, Marta Rachwalak, Malgorzata Rozniewska
A simple and convenient synthetic protocols based on H-phosphonate chemistry have been developed for the preparation of nucleoside 5′-diphosphates. It consists of oxidation of the silylated H-phosphonate monoesters in pyridine with iodine to produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736a79e9c675640ef8c7623eeeaf83d9
Autor:
Blazej A. Wojtczak, Edward Darzynkiewicz, Jacek Jemielity, Pedro Moreno, Roger Strömberg, Malgorzata Honcharenko, Joanna Romanowska, Burcu Bestas, Martina Jezowska, C. I. E. Smith, S. M. Bächle
Publikováno v:
RSC Advances. 6:51367-51373
Achieving higher nuclear concentrations by active transport may give potent therapeutic effects at lower doses for many drugs. A method of increasing nuclear uptake is the use of naturally existing Nuclear Localization Signals (NLS) by conjugating NL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2b04a438830210a988ba824574bcdcb
https://doi.org/10.1039/c6ra09568b
https://doi.org/10.1039/c6ra09568b
Publikováno v:
The Journal of organic chemistry. 83(10)
Mechanistic and stereochemical aspects of the reaction of boranephosphonate diesters with amines promoted by iodine were investigated. This is a complex, multistep reaction that ultimately produces the corresponding phosphoramidate diesters via a for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d88e72893edb7d56301ff6d789af1b4
https://pubmed.ncbi.nlm.nih.gov/29684279
https://pubmed.ncbi.nlm.nih.gov/29684279
Publikováno v:
Analytical and Bioanalytical Chemistry
Nucleotides, their analogues, and other phosphate esters and phosphoramidates often contain the triethylammonium cation as a counterion. We found that this may be lost during chromatographic purification or concentration of solutions, yielding produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca21d40a49b813b10b69eb8c327872d6
http://europepmc.org/articles/PMC4329187
http://europepmc.org/articles/PMC4329187
Autor:
Aleksandra Dąbrowska, Adam Kraszewski, Zofia M. Pietrusiewicz, Joanna Romanowska, Andrzej Guranowski, Marek Figlerowicz, Krystian Kolodziej, Andrzej Piasek, Jerzy Boryski, Jacek Stawinski, Andrzej Lipniacki, Michal Sobkowski, Agnieszka Szymanska-Michalak
Publikováno v:
Journal of Medicinal Chemistry. 54:6482-6491
New synthetic protocol for the preparation of nucleoside 5'-(N-aryl)phosphoramidate monoesters 4 was developed. It consisted of a condensation of the corresponding nucleoside 5'-H-phosphonates with aromatic- or heteroaromatic amines promoted by diphe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7991d9f8f0115544d6f9039bb9e2a11e
https://doi.org/10.1021/jm2001103
https://doi.org/10.1021/jm2001103