Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Joanna Proszek"'
Autor:
Joanna Proszek, Amit Roy, Ann-Katrine Jakobsen, Rikke Frøhlich, Birgitta R. Knudsen, Magnus Stougaard
Publikováno v:
Sensors, Vol 14, Iss 1, Pp 1195-1207 (2014)
Human topoisomerase I (hTopI) is an essential cellular enzyme. The enzyme is often upregulated in cancer cells, and it is a target for chemotherapeutic drugs of the camptothecin (CPT) family. Response to CPT-based treatment is dependent on hTopI acti
Externí odkaz:
https://doaj.org/article/87374361d474416883c9c7ce1e73c2ce
Autor:
Birgitta Ruth Knudsen, Oskar Franch, Joanna Proszek, Yi-Ping Ho, Magnus Stougaard, Emil Laust Kristoffersen, Lærke Bay Marcussen, Morten Leth Jepsen
Publikováno v:
Sensors, Vol 13, Iss 4, Pp 4017-4028 (2013)
Sensors capable of quantitative real-time measurements may present the easiest and most accurate way to study enzyme activities. Here we present a novel DNA-based sensor for specific and quantitative real-time measurement of the enzymatic activity of
Externí odkaz:
https://doaj.org/article/ff917ad60e1e44aa8d4d9504b4ea499a
Autor:
Joanna Proszek, Morten Leth Jepsen, Yi-Ping Ho, Magnus Stougaard, Birgitta R. Knudsen, Emil L. Kristoffersen, Oskar Franch, Lærke Bay Marcussen
Publikováno v:
Marcussen, L B, Jepsen, M L, Kristoffersen, E L, Franch, O, Proszek, J, Ho, Y-P, Stougaard, M & Knudsen, B R 2013, ' DNA-Based Sensor for Real-Time Measurement of the Enzymatic Activity of Human Topoisomerase I ', Sensors, vol. 13, no. 4, pp. 4017-4028 . https://doi.org/10.3390/s130404017
Sensors, Vol 13, Iss 4, Pp 4017-4028 (2013)
Sensors; Volume 13; Issue 4; Pages: 4017-4028
Sensors (Basel, Switzerland)
Sensors, Vol 13, Iss 4, Pp 4017-4028 (2013)
Sensors; Volume 13; Issue 4; Pages: 4017-4028
Sensors (Basel, Switzerland)
Sensors capable of quantitative real-time measurements may present the easiest and most accurate way to study enzyme activities. Here we present a novel DNA-based sensor for specific and quantitative real-time measurement of the enzymatic activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b671ab8696cf6caba186409e8d7298d
https://doi.org/10.3390/s130404017
https://doi.org/10.3390/s130404017
Autor:
Nils Brünner, Anne-Sofie Schrohl, Yves Pommier, Petra Hamerlik, Magnus Stougaard, John A. Foekens, Birgitta R. Knudsen, Signe Lykke Nielsen, José M.A. Moreira, Marcel Smid, Kristina Aluzaite, Stine Ninel Hansen, John W.M. Martens, Madhavsai K. Gajjar, Julie B. Noer, Britt Damsgaard, Haatisha Jandu, Louise Fogh, Khoa Nguyen Do, Jan Stenvang, Joanna Proszek, Sebastian Wingaard Thrane
Publikováno v:
Jandu, H, Aluzaite, K, Fogh, L, Thrane, S W, Noer, J B, Proszek, J, Do, K N, Hansen, S N, Damsgaard, B, Nielsen, S L, Stougaard, M, Knudsen, B R, Moreira, J, Hamerlik, P, Gajjar, M, Smid, M, Martens, J, Foekens, J, Pommier, Y, Brünner, N, Schrohl, A-S & Stenvang, J 2016, ' Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines ', BMC Cancer, vol. 16, no. 1, 34 . https://doi.org/10.1186/s12885-016-2071-1
BMC Cancer
Jandu, H, Aluzaite, K, Fogh, L, Thrane, S W, Noer, J B, Proszek, J, Nguyen Do, K, Hansen, S N, Damsgaard, B, Nielsen, S L, Stougaard, M, Knudsen, B R, Moreira, J, Hamerlik, P, Gajjar, M, Smid, M, Martens, J, Foekens, J, Pommier, Y, Brunner, N, Schrohl, A-S & Stenvang, J 2016, ' Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines ', B M C Cancer, vol. 16, no. 1, 34 . https://doi.org/10.1186/s12885-016-2071-1
BMC Cancer, 16:34. BioMed Central Ltd.
BMC Cancer
Jandu, H, Aluzaite, K, Fogh, L, Thrane, S W, Noer, J B, Proszek, J, Nguyen Do, K, Hansen, S N, Damsgaard, B, Nielsen, S L, Stougaard, M, Knudsen, B R, Moreira, J, Hamerlik, P, Gajjar, M, Smid, M, Martens, J, Foekens, J, Pommier, Y, Brunner, N, Schrohl, A-S & Stenvang, J 2016, ' Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines ', B M C Cancer, vol. 16, no. 1, 34 . https://doi.org/10.1186/s12885-016-2071-1
BMC Cancer, 16:34. BioMed Central Ltd.
Background Studies in taxane and/or anthracycline refractory metastatic breast cancer (mBC) patients have shown approximately 30 % response rates to irinotecan. Hence, a significant number of patients will experience irinotecan-induced side effects w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5e4ebd0162eaf53b4b940488188f58
https://doi.org/10.1186/s12885-016-2071-1
https://doi.org/10.1186/s12885-016-2071-1
Autor:
Ann-Katrine Jakobsen, Joanna Proszek, Magnus Stougaard, Henrik Hager, Birgitta R. Knudsen, Evelyn Benuja Samuel, Kristina Lystlund Lauridsen
Publikováno v:
Jakobsen, A-K, Lauridsen, K L, Samuel, E B, Proszek, J, Knudsen, B R, Hager, H & Stougaard, M 2015, ' Correlation between topoisomerase I and tyrosyl-DNA phosphodiesterase 1 activities in non-small cell lung cancer tissue ', Experimental and Molecular Pathology, vol. 99, no. 1, pp. 56-64 . https://doi.org/10.1016/j.yexmp.2015.05.006
Topoisomerase I (TOP1) regulates DNA topology during replication and transcription whereas tyrosyl-DNA phosphodiesterase 1 (TDP1) is involved in the repair of several types of DNA damages, including damages from defective TOP1 catalysis. TOP1 is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b2c8bac3a62f7942fc30b1d2133a19
https://pure.au.dk/portal/da/publications/correlation-between-topoisomerase-i-and-tyrosyldna-phosphodiesterase-1-activities-in-nonsmall-cell-lung-cancer-tissue(4b5f5554-eaae-4c8c-ac56-fb9c1898d719).html
https://pure.au.dk/portal/da/publications/correlation-between-topoisomerase-i-and-tyrosyldna-phosphodiesterase-1-activities-in-nonsmall-cell-lung-cancer-tissue(4b5f5554-eaae-4c8c-ac56-fb9c1898d719).html
