Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Joanna Parkinson"'
Autor:
Joanna Parkinson, Jesper Sundell, Dinko Rekić, Karin Nelander, Hans Ericsson, Ahmad Ebrahimi, Corina Dota, Mikael Sunnåker
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 2, Pp n/a-n/a (2024)
Abstract Mitiperstat is a myeloperoxidase inhibitor in clinical development for treatment of patients with heart failure and preserved or mildly reduced ejection fraction, non‐alcoholic steatohepatits and chronic obstructive pulmonary disease. We a
Externí odkaz:
https://doaj.org/article/dff24b86cd934119a37837e539c8eac6
Autor:
Victor Sokolov, Tatiana Yakovleva, Leonid Stolbov, Robert C. Penland, David Boulton, Joanna Parkinson, Weifeng Tang
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 6, Pp 831-841 (2023)
Abstract Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by abnormally high blood glucose concentrations due to dysfunction of the insulin‐producing beta‐cells in the pancreas. Dapagliflozin, an inhibitor of renal glucose r
Externí odkaz:
https://doaj.org/article/08d955a3d7174494a0f64eaccfc0dd49
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 2, Pp 108-118 (2021)
This analysis reports a quantitative modeling and simulation approach for oral dapagliflozin, a primarily uridine diphosphate‐glucuronosyltransferase (UGT)–metabolized human sodium‐glucose cotransporter 2 selective inhibitor. A mechanistic dapa
Externí odkaz:
https://doaj.org/article/04577c1c615147d1a35e59ffeccf1fba
Autor:
Margaret L McNeely, Joanna Parkinson
Publikováno v:
Journal of Physiotherapy, Vol 68, Iss 2, Pp 145- (2022)
Externí odkaz:
https://doaj.org/article/9b172196fe0345bfb096199cd546949b
Assumption Checking Before Application of the Prespecified QT Linear Mixed Effect Model is Essential
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 7, Pp 371-371 (2020)
Externí odkaz:
https://doaj.org/article/c31dfd2e74ac483a82c767c2f0b37a66
Autor:
Stanko Skrtic, Björn Tyrberg, Malin Broberg, Hans Ericsson, Volker Schnecke, Magnus Kjaer, Marcus Hompesch, Eva-Marie Andersson, Erik Ryberg, Alexander Aivazidis, Charlotte Wennberg Huldt, Lars Löfgren, Linda Morrow, Joanna Parkinson, Tina Rydén-Bergsten, Elaine Watkins, Maria Sörhede Winzell
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208998 (2018)
AIMS/HYPOTHESIS:GPR44 (DP2, PTGDR2, CRTh2) is the receptor for the pro-inflammatory mediator prostaglandin D2 (PGD2) and it is enriched in human islets. In rodent islets, PGD2 is produced in response to glucose, suggesting that the PGD2-GPR44/DP2 axi
Externí odkaz:
https://doaj.org/article/14eb9641fd434a2fbeda8df2991ce6e8
Autor:
Linnéa Bergenholm, David Lars Ivan Janzen, Mats Jirstrand, Joanna Parkinson, James Yates, Neil D Evans, Michael John Chappell
Publikováno v:
Frontiers in Physiology, Vol 7 (2016)
Issues of parameter identifiability of routinely used pharmacodynamics models are considered in this paper. The structural identifiability of 16 commonly applied pharmacodynamic model structures was analysed analytically, using the input-output appro
Externí odkaz:
https://doaj.org/article/c0650cc4323f4c7f9ab294f0f3d3caa6
Autor:
Joanna Parkinson, Corina Dota, Christian Källgren, Christer Gottfridsson, Magnus Bjursell, Shira Perl, Thomas Kӧrnicke, Dinko Rekić, Susanne Johansson
Publikováno v:
British Journal of Clinical Pharmacology. 89:1747-1755
This thorough QT/QTc (TQT) study was conducted to evaluate the risk of QT prolongation for verinurad when combined with allopurinol. Verinurad is a novel, urate anion exchanger 1 inhibitor that reduces serum urate levels by promoting urinary excretio
Autor:
Joanna Parkinson, David W. Boulton, Weifeng Tang, Robert C. Penland, Bengt Hamrén, Melin J, Dinko Rekić
Publikováno v:
The Journal of Clinical Pharmacology. 62:1227-1235
Aim: Dapagliflozin improves glycaemic control in patients with type 2 diabetes mellitus (T2DM) and is approved in European and Japanese patients with type 1 diabetes mellitus (T1DM) with inadequate glycaemic control. The objectives of this work were
Autor:
Victor Sokolov, Tatiana Yakovleva, Leonid Stolbov, Robert C. Penland, David Boulton, Joanna Parkinson, Weifeng Tang
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology.