Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Joanna P. Nicholls"'
Autor:
Nagy Habib, John J. Rossi, David C. Blakey, Hans E. Huber, Pal Saetrom, Chris Wood, Robert Habib, Jenni Vasara, Steve Felstead, Peter Lloyd, Pinelopi Andrikakou, Stephanie Dorman, Jon Voutila, Vikash Reebye, Sonia Fairbairn, Helen Glenny, Robert Nutbrown, David Collin, Joanna P. Nicholls, Vineet Kwatra, Sarah Hunter, James Spicer, David J. Pinato, Rohini Sharma, Madhava Pai, Duncan R.C. Spalding, T.R. Jeff Evans, Yuk Ting Ma, Daniel H. Palmer, Kai-Wen Huang, Cheng Ean Chee, Bristi Basu, Mikael H. Sodergren, Tim Meyer, Ruth Plummer, Debashis Sarker
A) CT and MRI of patient with prolonged partial response with MTL-CEBPA treatment B) IFN-gamma, NFkB and IL6 trend at days 1, 8 and 15 following treatment and C) AFP change at from baseline to 4, 8 and 16 weeks on treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ab81451fcfb34da9fcfeff4eda3c4e
https://doi.org/10.1158/1078-0432.22477086
https://doi.org/10.1158/1078-0432.22477086
Autor:
Nagy Habib, John J. Rossi, David C. Blakey, Hans E. Huber, Pal Saetrom, Chris Wood, Robert Habib, Jenni Vasara, Steve Felstead, Peter Lloyd, Pinelopi Andrikakou, Stephanie Dorman, Jon Voutila, Vikash Reebye, Sonia Fairbairn, Helen Glenny, Robert Nutbrown, David Collin, Joanna P. Nicholls, Vineet Kwatra, Sarah Hunter, James Spicer, David J. Pinato, Rohini Sharma, Madhava Pai, Duncan R.C. Spalding, T.R. Jeff Evans, Yuk Ting Ma, Daniel H. Palmer, Kai-Wen Huang, Cheng Ean Chee, Bristi Basu, Mikael H. Sodergren, Tim Meyer, Ruth Plummer, Debashis Sarker
Supplementary Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c7e811910e435bac98f627935365fd
https://doi.org/10.1158/1078-0432.22477080.v1
https://doi.org/10.1158/1078-0432.22477080.v1
Autor:
Nagy Habib, John J. Rossi, David C. Blakey, Hans E. Huber, Pal Saetrom, Chris Wood, Robert Habib, Jenni Vasara, Steve Felstead, Peter Lloyd, Pinelopi Andrikakou, Stephanie Dorman, Jon Voutila, Vikash Reebye, Sonia Fairbairn, Helen Glenny, Robert Nutbrown, David Collin, Joanna P. Nicholls, Vineet Kwatra, Sarah Hunter, James Spicer, David J. Pinato, Rohini Sharma, Madhava Pai, Duncan R.C. Spalding, T.R. Jeff Evans, Yuk Ting Ma, Daniel H. Palmer, Kai-Wen Huang, Cheng Ean Chee, Bristi Basu, Mikael H. Sodergren, Tim Meyer, Ruth Plummer, Debashis Sarker
Showing complete radiological response of lung metastases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77745179950de77a7a87e254666ef1c3
https://doi.org/10.1158/1078-0432.22477083.v1
https://doi.org/10.1158/1078-0432.22477083.v1
Autor:
Nagy Habib, John J. Rossi, David C. Blakey, Hans E. Huber, Pal Saetrom, Chris Wood, Robert Habib, Jenni Vasara, Steve Felstead, Peter Lloyd, Pinelopi Andrikakou, Stephanie Dorman, Jon Voutila, Vikash Reebye, Sonia Fairbairn, Helen Glenny, Robert Nutbrown, David Collin, Joanna P. Nicholls, Vineet Kwatra, Sarah Hunter, James Spicer, David J. Pinato, Rohini Sharma, Madhava Pai, Duncan R.C. Spalding, T.R. Jeff Evans, Yuk Ting Ma, Daniel H. Palmer, Kai-Wen Huang, Cheng Ean Chee, Bristi Basu, Mikael H. Sodergren, Tim Meyer, Ruth Plummer, Debashis Sarker
Dose escalation flow chart. DLT - dose limiting toxicity, MTD - maximum tolerated dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f45e2fcc07497a12f923f330fe0e40d
https://doi.org/10.1158/1078-0432.22477095.v1
https://doi.org/10.1158/1078-0432.22477095.v1
Autor:
Nagy Habib, John J. Rossi, David C. Blakey, Hans E. Huber, Pal Saetrom, Chris Wood, Robert Habib, Jenni Vasara, Steve Felstead, Peter Lloyd, Pinelopi Andrikakou, Stephanie Dorman, Jon Voutila, Vikash Reebye, Sonia Fairbairn, Helen Glenny, Robert Nutbrown, David Collin, Joanna P. Nicholls, Vineet Kwatra, Sarah Hunter, James Spicer, David J. Pinato, Rohini Sharma, Madhava Pai, Duncan R.C. Spalding, T.R. Jeff Evans, Yuk Ting Ma, Daniel H. Palmer, Kai-Wen Huang, Cheng Ean Chee, Bristi Basu, Mikael H. Sodergren, Tim Meyer, Ruth Plummer, Debashis Sarker
Trial Protocol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904983ab44a60b491e369e12d54f27a4
https://doi.org/10.1158/1078-0432.22477098
https://doi.org/10.1158/1078-0432.22477098
Autor:
Nagy Habib, John J. Rossi, David C. Blakey, Hans E. Huber, Pal Saetrom, Chris Wood, Robert Habib, Jenni Vasara, Steve Felstead, Peter Lloyd, Pinelopi Andrikakou, Stephanie Dorman, Jon Voutila, Vikash Reebye, Sonia Fairbairn, Helen Glenny, Robert Nutbrown, David Collin, Joanna P. Nicholls, Vineet Kwatra, Sarah Hunter, James Spicer, David J. Pinato, Rohini Sharma, Madhava Pai, Duncan R.C. Spalding, T.R. Jeff Evans, Yuk Ting Ma, Daniel H. Palmer, Kai-Wen Huang, Cheng Ean Chee, Bristi Basu, Mikael H. Sodergren, Tim Meyer, Ruth Plummer, Debashis Sarker
Supplementary Table 1 CEBPA-51 PK parameters Supplementary Table 2 RECIST 1.1 response observed overall and per cohorts in HCC patients at cut-off (12 Sep 2018) presented as n (%)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce35daac7a415cf4cb7dfd189462b42
https://doi.org/10.1158/1078-0432.22477077.v1
https://doi.org/10.1158/1078-0432.22477077.v1
Autor:
Nagy Habib, John J. Rossi, David C. Blakey, Hans E. Huber, Pal Saetrom, Chris Wood, Robert Habib, Jenni Vasara, Steve Felstead, Peter Lloyd, Pinelopi Andrikakou, Stephanie Dorman, Jon Voutila, Vikash Reebye, Sonia Fairbairn, Helen Glenny, Robert Nutbrown, David Collin, Joanna P. Nicholls, Vineet Kwatra, Sarah Hunter, James Spicer, David J. Pinato, Rohini Sharma, Madhava Pai, Duncan R.C. Spalding, T.R. Jeff Evans, Yuk Ting Ma, Daniel H. Palmer, Kai-Wen Huang, Cheng Ean Chee, Bristi Basu, Mikael H. Sodergren, Tim Meyer, Ruth Plummer, Debashis Sarker
Purpose:Transcription factor C/EBP-α (CCAAT/enhancer-binding protein alpha) acts as a master regulator of hepatic and myeloid functions and multiple oncogenic processes. MTL-CEBPA is a first-in-class small activating RNA oligonucleotide drug that up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655dfedd00417d62da05144f7bcb5f4f
https://doi.org/10.1158/1078-0432.c.6529569
https://doi.org/10.1158/1078-0432.c.6529569
Autor:
Nagy Habib, John J. Rossi, David C. Blakey, Hans E. Huber, Pal Saetrom, Chris Wood, Robert Habib, Jenni Vasara, Steve Felstead, Peter Lloyd, Pinelopi Andrikakou, Stephanie Dorman, Jon Voutila, Vikash Reebye, Sonia Fairbairn, Helen Glenny, Robert Nutbrown, David Collin, Joanna P. Nicholls, Vineet Kwatra, Sarah Hunter, James Spicer, David J. Pinato, Rohini Sharma, Madhava Pai, Duncan R.C. Spalding, T.R. Jeff Evans, Yuk Ting Ma, Daniel H. Palmer, Kai-Wen Huang, Cheng Ean Chee, Bristi Basu, Mikael H. Sodergren, Tim Meyer, Ruth Plummer, Debashis Sarker
Longitudinal changes in WBC mRNA expression of CEBPA, adenosine, PD-1 & CXCR4 at screening, day2, 8 and 15 of a single patient treated in the 130mg/m2 cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1792a6da256cefb45e0af3543b920792
https://doi.org/10.1158/1078-0432.22477089.v1
https://doi.org/10.1158/1078-0432.22477089.v1
Autor:
Nagy Habib, John J. Rossi, David C. Blakey, Hans E. Huber, Pal Saetrom, Chris Wood, Robert Habib, Jenni Vasara, Steve Felstead, Peter Lloyd, Pinelopi Andrikakou, Stephanie Dorman, Jon Voutila, Vikash Reebye, Sonia Fairbairn, Helen Glenny, Robert Nutbrown, David Collin, Joanna P. Nicholls, Vineet Kwatra, Sarah Hunter, James Spicer, David J. Pinato, Rohini Sharma, Madhava Pai, Duncan R.C. Spalding, T.R. Jeff Evans, Yuk Ting Ma, Daniel H. Palmer, Kai-Wen Huang, Cheng Ean Chee, Bristi Basu, Mikael H. Sodergren, Tim Meyer, Ruth Plummer, Debashis Sarker
qPCR of CEBPA mRNA levels at days 2, 8 and 15 following treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5169ba980674ca49d979868e07c38920
https://doi.org/10.1158/1078-0432.22477092.v1
https://doi.org/10.1158/1078-0432.22477092.v1
Autor:
Ruth Plummer, Mikael Sodergren, Brid Ryan, Ilian Tchakov, Nina Raulf, Rose Hodgson, CP Tan, Joanna P. Nicholls, Alison Adderkin, N Vasileiadou, Vikash Reebye, Tim Meyer, David J. Pinato, Debashis Sarker, Bristi Basu, Sarah Blagden, Natalie Cook, Jeff Evans, Jeffrey Yachnin, Cheng Ean Chee, Dan Li, Anthony El-Khoueiry, Maria Diab, Kai-Wen Huang, Marcus S. Noel, Bridget Keenan, Devalingam Mahalingam, Melanie Grosso, Denis Arnaud, Aurelie Auguste, Jan Storkholm, Iain McNeish, Robert Habib, John J. Rossi, Nagy Habib
Publikováno v:
Cancer Research. 83:LB192-LB192
Despite significant advances in outcomes with immunotherapy, most cancer patients do not benefit from currently approved immune checkpoint inhibitors (ICI). The reasons for ICI resistance are multi-faceted and suggest that additional immunomodulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38528265a8b16b1ba1fc63e1923727ba
https://doi.org/10.1158/1538-7445.am2023-lb192
https://doi.org/10.1158/1538-7445.am2023-lb192
