Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Joanna P. Davies"'
Autor:
Fannie W. Chen, Joanna P. Davies, Raul Calvo, Jagruti Chaudhari, Georgia Dolios, Mercedes K. Taylor, Samarjit Patnaik, Jean Dehdashti, Rebecca Mull, Patricia Dranchack, Amy Wang, Xin Xu, Emma Hughes, Noel Southall, Marc Ferrer, Rong Wang, Juan J. Marugan, Yiannis A. Ioannou
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104941- (2022)
Summary: Numerous studies have established the involvement of lysosomal and mitochondrial dysfunction in the pathogenesis of neurodegenerative disorders such as Alzheimer’s and Parkinson diseases. Building on our previous studies of the neurodegene
Externí odkaz:
https://doaj.org/article/e19a65a93a4f4b3fb15bf654a093fa23
Autor:
Ryan E. Temel, J. Mark Brown, Yinyan Ma, Weiqing Tang, Lawrence L. Rudel, Yiannis A. Ioannou, Joanna P. Davies, Liqing Yu
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 5, Pp 915-923 (2009)
Diosgenin exists in some food supplements and herbal medicines and lowers plasma cholesterol by increasing fecal cholesterol excretion. It is believed that diosgenin promotes fecal cholesterol excretion by stimulating biliary cholesterol secretion an
Externí odkaz:
https://doaj.org/article/5badcd60467a4150bff6b60e282e73e3
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 2, Pp 293-300 (2009)
Mice lacking Niemann-Pick C1-Like 1 (NPC1L1) (NPC1L1−/−mice) exhibit a defect in intestinal absorption of cholesterol and phytosterols. However, wild-type (WT) mice do not efficiently absorb and accumulate phytosterols either. Cell-based studies
Externí odkaz:
https://doaj.org/article/126b9716b70149cca880ad3cc33dcc3c
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 2, Pp 243-253 (2003)
Niemann-Pick C (NPC) disease is a rare recessive lipidosis marked by excessive accumulation of LDL-derived free cholesterol and glycosphingolipids in the late endosomal-lysosomal (E-L) system. Here we report that ectopic expression of human telomeras
Externí odkaz:
https://doaj.org/article/3896f101cefc42f9bd273c3eb79eaa50
Autor:
Fliss EM Murtagh, Ping Guo, Alice Firth, Ka Man Yip, Christina Ramsenthaler, Abdel Douiri, Cathryn Pinto, Sophie Pask, Mendwas Dzingina, Joanna M Davies, Suzanne O’Brien, Beth Edwards, Esther I Groeneveld, Mevhibe Hocaoglu, Claudia Bausewein, Irene J Higginson
Publikováno v:
Programme Grants for Applied Research, Vol 11, Iss 07 (2023)
Background The hospice movement has provided an excellent model of specialist palliative care for those with advanced illness approaching the end of life. However, there are marked inequities in provision of this care, and major geographical variatio
Externí odkaz:
https://doaj.org/article/80a4cce0f83a4a85a923ec5b2f105150
Autor:
Fannie W. Chen, Joanna P. Davies, Raul Calvo, Jagruti Chaudhari, Georgia Dolios, Mercedes K. Taylor, Samarjit Patnaik, Jean Dehdashti, Rebecca Mull, Patricia Dranchack, Amy Wang, Xin Xu, Emma Hughes, Noel Southall, Marc Ferrer, Rong Wang, Juan J. Marugan, Yiannis A. Ioannou
Publikováno v:
iScience. 25(9)
Numerous studies have established the involvement of lysosomal and mitochondrial dysfunction in the pathogenesis of neurodegenerative disorders such as Alzheimer's and Parkinson diseases. Building on our previous studies of the neurodegenerative lyso
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 2, Pp 293-300 (2009)
Mice lacking Niemann-Pick C1-Like 1 (NPC1L1) (NPC1L1(-/-)mice) exhibit a defect in intestinal absorption of cholesterol and phytosterols. However, wild-type (WT) mice do not efficiently absorb and accumulate phytosterols either. Cell-based studies sh
Autor:
Dean Gilham, David Y. Hui, Ronald J. Jandacek, Lisa M. Camarota, Joanna P. Davies, Patrick Tso, Eric Labonte, Philip N. Howles, Yiannis A. Ioannou, Juan C. Rojas
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 295:G776-G783
The impact of NPC1L1 and ezetimibe on cholesterol absorption are well documented. However, their potential consequences relative to absorption and metabolism of other nutrients have been only minimally investigated. Thus studies were undertaken to in
Autor:
Erick M. Carreira, Helmut Hauser, Phu T. Duong, Joanna P. Davies, Martin Knöpfel, Yiannis A. Ioannou, Lisbet Kvaerno, Michael C. Phillips
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1771:1140-1147
We compared cholesterol uptake into brush border membrane vesicles (BBMV) made from the small intestines of either wild-type or Niemann–Pick C1-like 1 (NPC1L1) knockout mice to elucidate the contribution of NPC1L1 to facilitated uptake; this uptake
Autor:
Lisa-Mari Nilsson, Joanna P. Davies, Yinyan Ma, Ryan E. Temel, Yiannis A. Ioannou, Weiqing Tang, Lawrence L. Rudel, Mark C. Willingham, Liqing Yu
Publikováno v:
Journal of Clinical Investigation. 117:1968-1978
Niemann-Pick C1–like 1 (NPC1L1) is required for cholesterol absorption. Intestinal NPC1L1 appears to be a target of ezetimibe, a cholesterol absorption inhibitor that effectively lowers plasma LDL-cholesterol in humans. However, human liver also ex