Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Joanna Matalinska"'
Publikováno v:
Acta Poloniae Pharmaceutica, Vol 80, Iss 3, Pp 363-372 (2023)
We were interested in finding smallest possible ligands of the NK1 receptor (NK1R). Based on structural considerations and molecular docking (scoring) we selected six simple (low molecular weight, MW) 3,5-bistrifluoromethylbenzene derivatives and tes
Externí odkaz:
https://doaj.org/article/205f630e627f425e90e4da8ebf17322e
Autor:
Bartłomiej Fedorczyk, Patrycja Redkiewicz, Joanna Matalińska, Radosław Piast, Piotr Kosson, Rafał Wieczorek
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 190 (2024)
The interaction of Neuropilin-1 (NRP-1) with vascular endothelial growth factor (VEGF) has been shown to promote angiogenesis under physiological and pathological conditions. Angiogenesis around tumors is a major factor allowing for their growth and
Externí odkaz:
https://doaj.org/article/c1d5d33be17848c0b805b58450319216
Autor:
Paweł K. Halik, Przemysław Koźmiński, Joanna Matalińska, Piotr F. J. Lipiński, Aleksandra Misicka, Ewa Gniazdowska
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 607 (2022)
Currently, the search for promising NK1R-positive tumor-targeting radiopharmaceuticals based on the structure of small molecular antagonists of neurokinin-1 receptor can be observed. Following this trend, we continued our evaluation of aprepitant-bas
Externí odkaz:
https://doaj.org/article/07bfb308c5454d1f949bdbfa1fc3e68e
Autor:
Joanna Matalińska, Piotr F. J. Lipiński, Piotr Kosson, Katarzyna Kosińska, Aleksandra Misicka
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7738 (2020)
AA3266 is a hybrid compound consisting of opioid receptor agonist and neurokinin-1 receptor (NK1R) antagonist pharmacophores. It was designed with the desire to have an analgesic molecule with improved properties and auxiliary anticancer activity. Pr
Externí odkaz:
https://doaj.org/article/a8938db87c144b71b71c01e25fc83891
Autor:
Sergiusz Markowicz, Joanna Matalinska, Katarzyna Kurzepa, Marta Bochynska, Marzena Biernacka, Anna Samluk, Dorota Dudek, Henryk Skurzak, Masaaki Yoshikawa, Andrzej W Lipkowski
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98073 (2014)
The primary function of hair and fur covering mammalian skin is to provide mechanical and thermal protection for the body. The proteins that constitute hair are extremely resistant to degradation by environmental factors. However, even durable materi
Externí odkaz:
https://doaj.org/article/ae38e2aa526c416bb14dab47a051200d
Akademický článek
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Autor:
Joanna, Matalinska, Henryk, Skurzak, Sergiusz, Markowicz, Anna, Lesniak, Mariusz, Sacharczuk, Gabriella, Molnar, Eva, Varga, Andrzej W, Lipkowski
Publikováno v:
Folia neuropathologica. 51(2)
Opiate analgesics like morphine or fentanyl are the most widely used medicines for relieving severe acute or chronic pain, including cancer pain. Unfortunately, chronic pain treatment is associated with fast development of tolerance that creates the
Publikováno v:
Folia Neuropathologica, Vol 58, Iss 3, Pp 237-244 (2020)
A neuropeptide, Substance P (SP), has mitogenic action in many types of cancer cells mediated via the neurokinin-1 receptor (NK1R). Small molecular NK1R antagonists have been frequently shown to possess anticancer activity both in vivo and in vitro,
Externí odkaz:
https://doaj.org/article/9f7955f988114505b9186be3206fb5c2
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2766 (2022)
One of the strategies in the search for safe and effective analgesic drugs is the design of multitarget analgesics. Such compounds are intended to have high affinity and activity at more than one molecular target involved in pain modulation. In the p
Externí odkaz:
https://doaj.org/article/881831b528724e4182cd7d4c33ac576d
Autor:
Ewa Witkowska, Magda Godlewska, Jowita Osiejuk, Sandra Gątarz, Beata Wileńska, Katarzyna Kosińska, Joanna Starnowska-Sokół, Anna Piotrowska, Piotr F. J. Lipiński, Joanna Matalińska, Jolanta Dyniewicz, Paweł K. Halik, Ewa Gniazdowska, Barbara Przewlocka, Aleksandra Misicka
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 674 (2022)
Based on the mechanism of neuropathic pain induction, a new type of bifunctional hybrid peptidomimetics was obtained for potential use in this type of pain. Hybrids consist of two types of pharmacophores that are connected by different types of linke
Externí odkaz:
https://doaj.org/article/5ac1bbccccea45039db1a0643d59e8af