Výsledky vyhledávání - "Joanna Marks"

Adaptive study design to assess effect of TRPV4 inhibition in patients with chronic cough

Autor: Valerie J. Ludbrook, James L. Kreindler, Misba Beerahee, Joanna Marks-Konczalik, Lorcan McGarvey, Jaclyn A. Smith, Nick P. Bird, SM Parker, Surinder S. Birring, Kate E Hanrott, David J. Behm, Alyn H. Morice, Debbie A Hewens

Publikováno v: Ludbrook, V J, Hanrott, K E, Kreindler, J L, Marks-Konczalik, J E, Bird, N P, Hewens, D A, Beerahee, M, Behm, D J, Morice, A, McGarvey, L, Parker, S M, Birring, S S & Smith, J 2021, ' Adaptive study design to assess effect of TRPV4 inhibition in patients with chronic cough ', ERJ Open Research, vol. 7, no. 3 . https://doi.org/10.1183/23120541.00269-2021
ERJ Open Research, Vol 7, Iss 3 (2021)
ERJ Open Research
article-version (VoR) Version of Record

Objective Airway sensory nerves involved in the cough reflex are activated by adenosine triphosphate (ATP) agonism of P2X purinoceptor 3 (P2X3) receptors. Transient receptor potential vanilloid 4 (TRPV4) channel activation causes ATP release from air

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3833a0555ff8bfff77b9a02a3d1dd6
https://www.research.manchester.ac.uk/portal/en/publications/adaptive-study-design-to-assess-effect-of-trpv4-inhibition-in-patients-with-chronic-cough(3d1d9e41-0831-44cc-bee7-6632854417f2).html

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Response to sertraline is associated with reduction in anxiety-potentiated startle in premenstrual dysphoric disorder

Autor: Liisa, Hantsoo, Christian, Grillon, Mary, Sammel, Rachel, Johnson, Joanna, Marks, C Neill, Epperson

Publikováno v: Psychopharmacology. 238(10)

Women with premenstrual dysphoric disorder (PMDD) appear to have altered central nervous system sensitivity to neuroactive steroid hormones, manifesting as affective symptoms and heightened arousal in the luteal phase of the menstrual cycle. In parti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e865117a383b274598a5d1181278a991
https://pubmed.ncbi.nlm.nih.gov/34292344

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S27 A placebo-controlled, double-blind, randomised, crossover study to assess the efficacy, safety and tolerability of TRPV4 inhibitor GSK2798745 in participants with chronic cough

Autor: David J. Behm, Alyn H. Morice, Joanna Marks-Konczalik, Surinder S. Birring, Nick P. Bird, Jeffrey S. Smith, Misba Beerahee, Valerie J. Ludbrook, SM Parker, Kate E Hanrott, Lorcan McGarvey, D Hewens, James L. Kreindler

Publikováno v: What’s new? Clinical trials in lung disease.

Introduction and objectives Airway sensory nerves involved in the cough reflex may be mediated by adenosine triphosphate (ATP) agonism of P2X purinoceptor 3 (P2X3) receptors. Transient receptor potential vanilloid 4 (TRPV4) activation causes ATP rele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9e175e52370693e0eaf4a86cbbf00d1
https://doi.org/10.1136/thorax-2019-btsabstracts2019.33

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Effects of a novel sodium channel blocker, GSK2339345, in patients with refractory chronic cough

Autor: Huda Badri, Joanna Marks-Konczalik, Imran Satia, Kathryn Povey, Lorcan McGarvey, Francis Warren, Jaclyn A. Smith, Lia Liefaard, Robert D. Murdoch, Sarah Siederer

Publikováno v: International journal of clinical pharmacology and therapeutics. 55(9)

Objective Voltage-gated sodium channels (VGSC) are important in the initiation and propagation of action potentials in afferent sensory nerve fibers responsible for evoking cough. This study investigated the efficacy of GSK2339345, a VGSC inhibitor,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7171ecc49f49c77564e5e130d591d1c8
https://pubmed.ncbi.nlm.nih.gov/28679467

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T146. Anxiety-Potentiated Startle Reductions Correlate With Symptom Reduction by Sertraline in Premenstrual Dysphoric Disorder (PMDD)

Autor: C. Neill Epperson, Joanna Marks, Brendan McGeehan, Liisa Hantsoo, Christian Grillon, Mary D. Sammel

Publikováno v: Biological Psychiatry. 83:S185

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::278ca1e42f70f4eead87f63fc86b5668
https://doi.org/10.1016/j.biopsych.2018.02.483

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A post-hoc subgroup analysis of data from a six month clinical trial comparing the efficacy and safety of losmapimod in moderate-severe COPD patients with ≤2% and2% blood eosinophils

Autor: Elizabeth McKie, Jon Robertson, Maria Costa, Joanna Marks-Konczalik, Steven Pascoe, Shuying Yang

Publikováno v: Respiratory medicine. 109(7)

Summary Background A six month study of the p38 MAPK inhibitor, losmapimod, suggested a trend in reducing COPD exacerbations with the 15 mg twice daily dose. Objective and methods Using data from this study which evaluated the efficacy of twice daily

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa779a66376fdf2f0e2ed1e8d7c7925a
https://pubmed.ncbi.nlm.nih.gov/26033641

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Mitogen-activated Protein Kinases Mediate Activator Protein-1-dependent Human Inducible Nitric-oxide Synthase Promoter Activation

Autor: Arnold S. Kristof, Joanna Marks-Konczalik, Joel Moss

Publikováno v: Journal of Biological Chemistry. 276:8445-8452

Inducible nitric-oxide synthase (iNOS) is an important signaling protein involved in the regulation of biological processes (e.g. vasodilation, inflammation) and is subject to transcriptional regulation by cytokines and lipopolysaccharide (LPS). Full

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59dae7512f6fa918df574a4f46770075
https://doi.org/10.1074/jbc.m009563200

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IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice

Autor: Joanna Marks-Konczalik, Jacqueline M. Losi, Sigrid Dubois, Yutaka Tagaya, Helen Sabzevari, Thomas A. Waldmann, Nobuo Yamada, Lionel Feigenbaum

Publikováno v: Proceedings of the National Academy of Sciences. 97:11445-11450

A transgenic (Tg) mouse expressing human IL-15 was generated to define the role of IL-15 in the normal immune response. Overexpression of IL-15 resulted in an increase of NK, CD44 hi CD8 memory T cells, and γδ T cells. Additionally, we observed the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc69472976ce295516621d684bbd7664
https://doi.org/10.1073/pnas.200363097

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Analysis of the Cytokine-Stimulated Human Inducible Nitric Oxide Synthase (iNOS) Gene: Characterization of Differences between Human and Mouse iNOS Promoters

Autor: Shan C. Chu, Hai-Ping Wu, Tyrone C. Banks, Joel Moss, Joanna Marks-Konczalik

Publikováno v: Biochemical and Biophysical Research Communications. 248:871-878

Expression of human inducible nitric oxide synthase (hiNOS) is under cytokine control and is transcriptionally regulated. The hiNOS and mouse iNOS (miNOS) genes are regulated differently by cytokines. To understand better the transcriptional regulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95abb81acd3564bfc7ea6e4c8911196
https://doi.org/10.1006/bbrc.1998.9062

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