Výsledky vyhledávání - "Joanna Maddela"

Fibronectin, DHPS and SLC3A2 Signaling Cooperate to Control Tumor Spheroid Growth, Subcellular eIF5A1/2 Distribution and CDK4/6 Inhibitor Resistance

Autor: Cameron Geller, Joanna Maddela, Ranel Tuplano, Farhana Runa, Yvess Adamian, Robert Güth, Gabriela Ortiz Soto, Luke Tomaneng, Joseph Cantor, Jonathan A. Kelber

Extracellular matrix (ECM) protein expression/deposition within and stiffening of the breast cancer microenvironment facilitates disease progression and correlates with poor patient survival. However, the mechanisms by which ECM components control tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25dcc9f39960b1d637ad9073f559d9dd
https://doi.org/10.1101/2023.04.13.536765

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Abstract 996: Fibronectin exposes a targetable DHPS/SLC3A2 vulnerability that can be leveraged to decrease cytoplasmic levels of eIF5A1/2 and proliferation/survival in TNBC

Autor: Cameron Geller, Joanna Maddela, Ranel Tuplano, Joseph Cantor, Jonathan A. Kelber

Publikováno v: Cancer Research. 82:996-996

Breast cancer ranks first among female cancer-related deaths in 2021, and fewer than 20% of patients survive five years after metastasis. Triple negative breast cancer (TNBC or basal) is highly aggressive and particularly difficult to treat due to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5cd50db27ba40b93bd113317ff4cc42d
https://doi.org/10.1158/1538-7445.am2022-996

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